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Cited by 26Tissue Engineering and Regenerative Medicine3D Printing in Biomedical ResearchHydrogels: synthesis, properties, applications

The DOI matches its Crossref record.

New Insights into the Pros and Cons of Cross-Linking Decellularized Bioartificial Organs

Hussein, Kamal H., Park, Kyung-Mee, Lee, Yun-Suk, Woo, Jae-Seok, Kang, Byung-Jae, Choi, Ki-Young, Kang, Kyung-Sun, Woo, Heung-Myong·2017·The International Journal of Artificial Organs
DOI 10.5301/ojao.5000541
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Abstract

Decellularization is an attractive method for scaffold designing in regenerative medicine. The resulting extracellular matrix (ECM) consists of structural proteins such as collagen and elastin, growth factors, and glycosaminoglycans, which can direct site-appropriate remodeling after in vivo implantation. Mainly, collagen and elastin of ECM are exposed to the enzymatic biodegradation in the host. To control the biodegradation process, treatment of decellularized tissue by a cross-linking agent is required. Cross-linking also reduces antigenicity and increases the storage properties. Cross-linkers should be nontoxic, with the ability to preserve the ECM components, especially glycosaminoglycans and associated growth factors for retention of scaffold bioactivity. In this review, we describe the different cross-linking agents and methods of evaluation of cross-linking efficiency.

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Crossref · 10.5301/ojao.5000541

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  • Cross-linking agents have been successfully employed to enhance enzymatic resistance, matrix decomposition, and ultimately improve biomechanical strength in various tissues and organs.

    “Cross-linking agents have been successfully employed to enhance enzymatic resistance, matrix decomposition, and ultimately improve biomechanical strength in various tissues and organs [[171], [172], [173]].”

    From Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities (2024) · cites this paper as [173]

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Metadata

Authors
Hussein, K. H., Park, K.-M., Lee, Y.-S., Woo, J.-S., Kang, B.-J., Choi, K.-Y., Kang, K.-S., & Woo, H.-M.
Affiliations
  • Stem Cell Institute, Kangwon National University, Chuncheon, Gangwon - Republic of Korea
  • Department of Animal Resources, Development Swine Science Division, National Institute of Animal Science, Rural Development Administration, Cheonan, Chungcheongnam - Republic of Korea
  • College of Veterinary Medicine, Kangwon National University, Chuncheon, Gangwon - Republic of Korea
  • Department of Controlled Agriculture, Kangwon National University, Chuncheon, Gangwon - Republic of Korea
  • Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul - Republic of Korea
ORCID
Venue
The International Journal of Artificial Organs
Publisher
SAGE Publications
Published
2017-04
Volume
40
Issue
4
Pages
136-141
ISSN
  • 0391-3988 (ISSN-L)
  • 1724-6040
DOI
10.5301/ojao.5000541
OpenAlex
W4253952290
Cited by
26
References
0
Citations by year
2025: 1 · 2024: 5 · 2023: 6 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 2
FWCI
2.53
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • The International Journal of Artificial Organs (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Keywords
crosslinking, decellularization, bioartificial organs, tissue engineering

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