Association between Non-High-Density Lipoprotein Cholesterol Levels and the Incidence of Coronary Heart Disease among Japanese: The Circulatory Risk in Communities Study (CIRCS)

Kitamura, Akihiko; Noda, Hiroyuki; Nakamura, Masakazu; Kiyama, Masahiko; Okada, Takeo; Imano, Hironori; Ohira, Tetsuya; Sato, Shinichi; Yamagishi, Kazumasa; Iso, Hiroyasu

doi:10.5551/jat.7237

Cited by 51Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Health and Risk Factors

Association between Non-High-Density Lipoprotein Cholesterol Levels and the Incidence of Coronary Heart Disease among Japanese: The Circulatory Risk in Communities Study (CIRCS)

Open access

Kitamura, Akihiko, Noda, Hiroyuki, Nakamura, Masakazu, Kiyama, Masahiko, Okada, Takeo, Imano, Hironori, Ohira, Tetsuya, Sato, Shinichi +2 more·2011·Journal of Atherosclerosis and Thrombosis

DOI 10.5551/jat.7237

Open this paper in CoChat — free account Open PDF

Abstract

AIM: The aim of this study was to identify the threshold level for non-high-density lipoprotein cholesterol (non-HDL-cholesterol) to raise the risk of coronary heart disease (CHD) incidence in a Japanese general population. METHODS: A total of 8,132 men and women, aged 40 to 69 years with no history of stroke or CHD, completed the baseline risk factor surveys between 1975 and 1987. Systematic surveillance of cardiovascular disease incidence was performed through 2003 (the median follow-up period was 21.9 years), and 155 incidents of CHD were identified. RESULTS: We found a statistically significant association between non-HDL-cholesterol levels and the risk of CHD with a threshold around 140 mg/dL. After adjustment for potential confounding factors, this association did not change materially. The multivariable hazard ratio of CHD compared with that for levels of < 100 mg/dL was 2.49 (95% confidence interval: 1.35 to 4.61) for 140-159 mg/dL and 3.13 (1.58-6.21) for ≥ 180 mg/dL. Setting the cut-off point at ≥ 140 mg/dL non-HDL-cholesterol resulted in the greatest improvement of integrated discrimination. CONCLUSIONS: Higher concentrations of non-HDL-cholesterol are associated with an increased risk of CHD with a threshold around 140 mg/dL, suggesting that the optimal cut-off point for healthy per-sons to prevent increasing the risk of CHD might be around 140 mg/dL non-HDL-cholesterol.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.5551/jat.7237

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Non-HDL-C is associated with CAD in many Japanese epidemiological surveys.
“The association between non-HDL-C and CAD has been reported in the results of many epidemiological surveys conducted in Japan51, 63–70).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [70]
Non-HDL-C is associated with CAD in many Japanese epidemiological surveys.
“The association between non-HDL-C and CAD has been reported in the results of many epidemiological surveys conducted in Japan51, 63–70).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [63]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A new look at the statistical model identification
Akaike, H. (1974) · IEEE Transactions on Automatic Control · doi:10.1109/tac.1974.1100705 · Cited by 51,879 · see citing works
Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423 · see citing works
Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report.
(2002) · Circulation · doi:10.1161/circ.106.25.3143 · Cited by 14,092 · see citing works
Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines
Grundy, S. M., Cleeman, J. I., Merz, C. N. B., Brewer, H. B., Clark, L. T., Hunninghake, D. B., Pasternak, R. C., Smith, S. C., & Stone, N. J. (2004) · Circulation · doi:10.1161/01.cir.0000133317.49796.0e · Cited by 6,902 · see citing works
Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond
Pencina, M. J., D' Agostino, R. B., D' Agostino, R. B., & Vasan, R. S. (2008) · Statistics in Medicine · doi:10.1002/sim.2929 · Cited by 6,493 · see citing works
1999 World Health Organization-International Society of Hypertension Guidelines for the Management of Hypertension
Subcommittee, G. (1999) · Journal of Hypertension · doi:10.1097/00004872-199917020-00001 · Cited by 3,895 · see citing works
Flexible regression models with cubic splines
Durrleman, S., & Simon, R. M. (1989) · Statistics in Medicine · doi:10.1002/sim.4780080504 · Cited by 2,701 · see citing works
Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths
(2007) · The Lancet · doi:10.1016/s0140-6736(07)61778-4 · Cited by 2,331 · see citing works
Comments on ‘Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond’ by M. J. Pencina, R. B. D'Agostino Sr, R. B. D'Agostino Jr, R. S. Vasan, Statistics in Medicine (DOI: 10.1002/sim.2929)
Greenland, P. (2007) · Statistics in Medicine · doi:10.1002/sim.2976 · Cited by 1,300 · see citing works
1993 guidelines for the management of mild hypertension. Memorandum from a World Health Organization/International Society of Hypertension meeting. Guidelines Subcommittee of the WHO/ISH Mild Hypertension Liaison Committee.
(1993) · Hypertension · doi:10.1161/01.hyp.22.3.392 · Cited by 1,203 · see citing works
Non–HDL Cholesterol, Apolipoproteins A-I and B <sub>100</sub> , Standard Lipid Measures, Lipid Ratios, and CRP as Risk Factors for Cardiovascular Disease in Women
Ridker, P. M., Rifai, N., Cook, N. R., Bradwin, G., & Buring, J. E. (2005) · JAMA · doi:10.1001/jama.294.3.326 · Cited by 744 · see citing works
Non–High-Density Lipoprotein Cholesterol Level as a Predictor of Cardiovascular Disease Mortality
Cui, Y. A., Blumenthal, R. S., Flaws, J. A., Whiteman, M. K., LANGENBERG, P. W., Bachorik, P. S., & Bush, T. L. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.11.1413 · Cited by 657 · see citing works
Non-high-density lipoprotein cholesterol and apolipoprotein B in the prediction of coronary heart disease in men
Pischon, T., Girman, C. J., Sacks, F. M., Rifai, N., Stampfer, M. J., & Rimm, E. B. (2005) · Circulation · doi:10.1161/circulationaha.104.532499 · Cited by 514 · see citing works
Non-high-density lipoprotein and very-low-density lipoprotein cholesterol and their risk predictive values in coronary heart disease
Liu, J., Sempos, C. T., Donahue, R. P., Dorn, J., Trevisan, M., & Grundy, S. M. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.06.032 · Cited by 277 · see citing works
Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines
Grundy, S. M., Cleeman, J. I., Merz, C. N. B., Brewer, H. B., Clark, L. T., Hunninghake, D. B., Pasternak, R. C., Smith, S. C., & Stone, N. J. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000133317.49796.0e · Cited by 195 · see citing works
Trends in the Incidence of Coronary Heart Disease and Stroke and Their Risk Factors in Japan, 1964 to 2003
Kitamura, A., Sato, S., Kiyama, M., Imano, H., Iso, H., Okada, T., Ohira, T., Tanigawa, T., Yamagishi, K., Nakamura, M., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.02.075 · Cited by 170 · see citing works
Self-citation
Improvement in Japanese Clinical Laboratory Measurements of Total Cholesterol and HDL-cholesterol by the US Cholesterol Reference Method Laboratory Network
Nakamura, M., Sato, S., & Shimamoto, T. (2003) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.10.145 · Cited by 159 · see citing works
Self-citation
The Relative Strength of C-Reactive Protein and Lipid Levels as Determinants of Ischemic Stroke Compared With Coronary Heart Disease in Women
Everett, B. M., Kurth, T., Buring, J. E., & Ridker, P. M. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.09.030 · Cited by 130 · see citing works
Low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol and the incidence of cardiovascular disease in an urban Japanese cohort study: The Suita study
Okamura, T., Kokubo, Y., Watanabe, M., Higashiyama, A., Miyamoto, Y., Yoshimasa, Y., & Okayama, A. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.07.020 · Cited by 123 · see citing works
Trends for Blood Pressure and Its Contribution to Stroke Incidence in the Middle-Aged Japanese Population
Imano, H., Kitamura, A., Sato, S., Kiyama, M., Ohira, T., Yamagishi, K., Noda, H., Tanigawa, T., Iso, H., & Shimamoto, T. (2009) · Stroke · doi:10.1161/strokeaha.108.538629 · Cited by 116 · see citing works
Self-citation
Apolipoprotein B and non-high density lipoprotein cholesterol and the risk of coronary heart disease in Chinese
Chien, K.-L., Hsu, H.-C., Su, T.-C., Chen, M.-F., Lee, Y.-T., & Hu, F. B. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700213-jlr200 · Cited by 109 · see citing works
Serum Total and Non-High-Density Lipoprotein Cholesterol and the Risk Prediction of Cardiovascular Events: – The JALS-ECC –
Tanabe, N., Iso, H., Okada, K., Nakamura, Y., Harada, A., Ohashi, Y., Ando, T., Ueshima, H., & The Japan Arteriosclerosis Longitudinal Study Group (2010) · Circulation Journal · doi:10.1253/circj.cj-09-0861 · Cited by 99 · see citing works
Self-citation
Association between Non-High-Density Lipoprotein Cholesterol Concentrations and Mortality from Coronary Heart Disease Among Japanese Men and Women: The Ibaraki Prefectural Health Study
Noda, H., Iso, H., Irie, F., Sairenchi, T., Ohtaka, E., & Ohta, H. (2010) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.1016 · Cited by 32 · see citing works
Self-citation
Measurement Performance of Reagent Manufacturers by Centers for Disease Control and Prevention/Cholesterol Reference Method Laboratory Network Lipid Standardization Specified for Metabolic Syndrome-Focused Health Checkups Program in Japan
Nakamura, M., Koyama, I., Iso, H., Sato, S., Okazaki, M., Kiyama, M., Shimamoto, T., & Konishi, M. (2009) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.1503 · Cited by 18 · see citing works
Self-citation

Flagged first, then by citations

1 of the 25 references couldn’t be matched to a known paper.

Sorted by citations

Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017
Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813 · see citing works
Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2022
Okamura, T., Tsukamoto, K., Arai, H., Fujioka, Y., Ishigaki, Y., Koba, S., Ohmura, H., Shoji, T., Yokote, K., Yoshida, H., et al. (2023) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2022 · Cited by 317 · see citing works
Cardiovascular Disease Epidemiology in Asia
Ohira, T., & Iso, H. (2013) · Circulation Journal · doi:10.1253/circj.cj-13-0702 · Cited by 253 · see citing works
Self-citation
Diagnostic Criteria for Dyslipidemia
Teramoto, T., Sasaki, J., Ishibashi, S., Birou, S., Daida, H., Dohi, S., Egusa, G., Hiro, T., Hirobe, K., Iida, M., et al. (2013) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.17152 · Cited by 168 · see citing works
The Circulatory Risk in Communities Study (CIRCS): A Long-Term Epidemiological Study for Lifestyle-Related Disease Among Japanese Men and Women Living in Communities
Yamagishi, K., Muraki, I., Kubota, Y., Hayama‐Terada, M., Imano, H., Cui, R., Umesawa, M., Shimizu, Y., Sankai, T., Okada, T., et al. (2018) · Journal of Epidemiology · doi:10.2188/jea.je20180196 · Cited by 57 · see citing works
Self-citation
Non‐high‐density lipoprotein cholesterol: An important predictor of stroke and diabetes‐related mortality in Japanese elderly diabetic patients
Araki, A., Iimuro, S., Sakurai, T., Umegaki, H., Iijima, K., Nakano, H., Oba, K., Yokono, K., Sone, H., Yamada, N., et al. (2012) · Geriatrics & Gerontology International · doi:10.1111/j.1447-0594.2011.00809.x · Cited by 49 · see citing works
JCS 2023 Guideline on the Primary Prevention of Coronary Artery Disease
Fujiyoshi, A., Kohsaka, S., Hata, J., Hara, M., Kai, H., Masuda, D., Miyamatsu, N., Nishio, Y., Ogura, M., Sata, M., et al. (2024) · Circulation Journal · doi:10.1253/circj.cj-23-0285 · Cited by 47 · see citing works
Non-High-Density Lipoprotein Cholesterol and Risk of Stroke Subtypes and Coronary Heart Disease: The Japan Public Health Center-Based Prospective (JPHC) Study
Saito, I., Yamagishi, K., Kokubo, Y., Yatsuya, H., Iso, H., Sawada, N., Inoue, M., & Tsugane, S. (2019) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.50385 · Cited by 46 · see citing works
Self-citation
High-Risk Atherosclerotic Cardiovascular Disease in a Real-World Employed Japanese Population: Prevalence, Cardiovascular Event Rates, and Costs
Davis, K. L., Meyers, J., Zhao, Z., McCollam, P. L., & Murakami, M. (2015) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.28852 · Cited by 44 · see citing works
Influence of antiepileptic drugs on serum lipid levels in adult epilepsy patients
Yamamoto, Y., Terada, K., Takahashi, Y., Imai, K., Kagawa, Y., & Inoue, Y. (2016) · Epilepsy Research · doi:10.1016/j.eplepsyres.2016.08.027 · Cited by 41 · see citing works
Flaxseed Oil Containingα-Linolenic Acid Ester of Plant Sterol Improved Atherosclerosis in ApoE Deficient Mice
Han, H., Yan, P., Chen, L., Luo, C., Gao, H. Y., Deng, Q., Zheng, M., Shi, Y., & Liu, L. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/958217 · Cited by 36 · see citing works
Associations of Carotid Intima‐Media Thickness and Plaque Heterogeneity With the Risks of Stroke Subtypes and Coronary Artery Disease in the Japanese General Population: The Circulatory Risk in Communities Study
Shimoda, S., Kitamura, A., Imano, H., Cui, R., Muraki, I., Yamagishi, K., Umesawa, M., Sankai, T., Hayama‐Terada, M., Kubota, Y., et al. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.120.017020 · Cited by 36 · see citing works
Self-citation
Impact of Hypertension and Subclinical Organ Damage on the Incidence of Cardiovascular Disease Among Japanese Residents at the Population and Individual Levels ― The Circulatory Risk in Communities Study (CIRCS) ―
Kitamura, A., Yamagishi, K., Imano, H., Kiyama, M., Cui, R., Ohira, T., Umesawa, M., Muraki, I., Sankai, T., Saito, I., et al. (2017) · Circulation Journal · doi:10.1253/circj.cj-16-1129 · Cited by 35 · see citing works
Self-citation
Clinical assessment and management of dyslipidemia in patients with chronic kidney disease
Nitta, K. (2012) · Clinical and Experimental Nephrology · doi:10.1007/s10157-012-0655-x · Cited by 32 · see citing works
Relationship between non-high-density lipoprotein cholesterol and the long-term mortality of cardiovascular diseases: NIPPON DATA 90
Ito, T., Arima, H., Fujiyoshi, A., Miura, K., Takashima, N., Ohkubo, T., Kadota, A., Hayakawa, T., Kita, Y., Miyagawa, N., et al. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.06.021 · Cited by 32 · see citing works
Non-High-Density Lipoprotein Cholesterol on the Risks of Stroke: A Result from the Kailuan Study
Wu, J., Chen, S., Zhou, Y., Wang, C., Wang, A., Zhang, Q., Gao, X., Hu, H., Wu, S., & Zhao, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074634 · Cited by 31 · see citing works
Reference Ranges for the Non-High-Density Lipoprotein Cholesterol Levels in Japanese Children and Adolescents
Abe, Y., Okada, T., スギウラ, レ., Yamauchi, K., & Murata, M. (2015) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.28100 · Cited by 29 · see citing works
Self-citation
Rice bran extract containing acylated steryl glucoside fraction decreases elevated blood LDL cholesterol level in obese Japanese men
Ito, Y., Nakashima, Y., & Matsuoka, S. (2015) · The Journal of Medical Investigation · doi:10.2152/jmi.62.80 · Cited by 29 · see citing works
Residual Atherosclerotic Cardiovascular Disease Risk: Focus on Non-High-Density Lipoprotein Cholesterol
Luo, Y., & Peng, D. (2023) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/10742484231189597 · Cited by 30 · see citing works
Rice Bran Extract Reduces the Risk of Atherosclerosis in Post-Menopausal Vietnamese Women
Nhung, B. T., Tuyên, L. D., Vu Anh, L. I. N. H., Anh, N. D. V., Tran, N. T., Thuc, V. T. M., Yui, K., Ito, Y., NAKASHIMA, Y., & Yamamoto, S. (2016) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.62.295 · Cited by 28 · see citing works
Meta-analysis of serum non-high-density lipoprotein cholesterol and risk of coronary heart disease in the general population
Liu, H., Deng, X., Peng, Y., Zeng, Q., Song, Z., He, W., Zhang, L., Gao, G., Xiao, T., & Yu, X. (2017) · Clinica Chimica Acta · doi:10.1016/j.cca.2017.05.006 · Cited by 28 · see citing works
Relationship between Non-High-Density Lipoprotein Cholesterol and Low-Density Lipoprotein Cholesterol in the General Population: the KOBE Study and Tsuruoka Metabolomic Cohort Study
Kuwabara, K., Harada, S., Sugiyama, D., Kurihara, A., Kubota, Y., Higashiyama, A., Hirata, T., Nishida, Y., Kawasaki, M., Takebayashi, T., et al. (2016) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.33100 · Cited by 26 · see citing works
Seaweed Intake and Risk of Cardiovascular Disease: The Circulatory Risk in Communities Study (CIRCS)
Chichibu, H., Yamagishi, K., Kishida, R., Maruyama, K., Hayama‐Terada, M., Shimizu, Y., Muraki, I., Umesawa, M., Cui, R., Imano, H., et al. (2021) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.61390 · Cited by 22 · see citing works
Self-citation
Predictive Value of Lipoprotein Indices for Residual Risk of Acute Myocardial Infarction and Sudden Death in Men With Low-Density Lipoprotein Cholesterol Levels <120 mg/dl
Tanaka, F., Makita, S., Onoda, T., Tanno, K., Ohsawa, M., Itai, K., Sakata, K., Omama, S.-I., Yoshida, Y., Ogasawara, K., et al. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2013.05.049 · Cited by 19 · see citing works
Self-citation
Relationship between Cardiorespiratory Fitness and Non-High-Density Lipoprotein Cholesterol: A Cohort Study
Watanabe, N., Sawada, S. S., Shimada, K., Lee, I.-M. M., Gando, Y., Momma, H., Kawakami, R., Miyachi, M., Hagi, Y., Kinugawa, C., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.43851 · Cited by 19 · see citing works
Blood Cholesterol Level and Risk of Stroke in Community-based or Worksite Cohort Studies: A Review of Japanese Cohort Studies in the Past 20 years
Tanaka, T., & Okamura, T. (2012) · The Keio Journal of Medicine · doi:10.2302/kjm.61.79 · Cited by 18 · see citing works
Safety and efficacy of long-term combination therapy with bezafibrate and ezetimibe in patients with dyslipidemia in the prospective, observational J-COMPATIBLE study
Teramoto, T., Abe, K., & Taneyama, T. (2013) · Cardiovascular Diabetology · doi:10.1186/1475-2840-12-163 · Cited by 16 · see citing works
Association of hypercholesterolemia and cardiac function evaluated by speckle tracking echocardiography in a rabbit model
Liu, L., Mu, Y., Han, W., & Wang, C. (2014) · Lipids in Health and Disease · doi:10.1186/1476-511x-13-128 · Cited by 16 · see citing works
Serum non-high-density lipoprotein cholesterol (non-HDL-C) levels and cardiovascular mortality in chronic hemodialysis patients
Echida, Y., Ogawa, T., Otsuka, K., Ando, Y., & Nitta, K. (2012) · Clinical and Experimental Nephrology · doi:10.1007/s10157-012-0615-5 · Cited by 16 · see citing works
Lipid and Blood Pressure Control for the Prevention of Cardiovascular Disease in Hypertensive Patients: A Subanalysis of the OMEGA Study
Teramoto, T., Kawamori, R., Miyazaki, S., Teramukai, S., Sato, Y., Okuda, Y., & Shirayama, M. (2014) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.25304 · Cited by 15 · see citing works
HDL cholesterol performance using an ultracentrifugation reference measurement procedure and the designated comparison method
Nakamura, M., Yokoyama, S., Kayamori, Y., Iso, H., Kitamura, A., Okamura, T., Kiyama, M., Noda, H., Nishimura, K., Nakai, M., et al. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.10.039 · Cited by 15 · see citing works
Self-citation
Determinants of Bezafibrate-induced Improvements in LDL Cholesterol in Dyslipidemic Patients with Diabetes
Hirose, T., Teramoto, T., Abe, K., Taneyama, T., & J-BENEFIT study group (2015) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.27425 · Cited by 13 · see citing works
Association between Indoor Temperature in Winter and Serum Cholesterol: A Cross-Sectional Analysis of the Smart Wellness Housing Survey in Japan
Umishio, W., Ikaga, T., Kario, K., Fujino, Y., Suzuki, M., Hoshi, T., Ando, S., Yoshimura, T., Yoshino, H., & Murakami, S. (2022) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.63494 · Cited by 14 · see citing works
Comparison of cardiovascular disease risk associated with 3 lipid measures in Japanese adults
Takeuchi, T., Nemoto, K.-I., Takahashi, O., Urayama, K. Y., Deshpande, G. A., & Izumo, H. (2014) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2014.06.005 · Cited by 12 · see citing works
Absolute Risk of Cardiovascular Disease and Lipid Management Targets
Teramoto, T., Sasaki, J., Ishibashi, S., Birou, S., Daida, H., Dohi, S., Egusa, G., Hiro, T., Hirobe, K., Iida, M., et al. (2013) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.17392 · Cited by 10 · see citing works
Systematic Analysis of Risk Factors for Coronary Heart Disease in Japanese Patients with Type 2 Diabetes: A Matched Case-Control Study
Fumisawa, Y., Funase, Y., Yamashita, K., Yamauchi, K., Miyamoto, T., Tsunemoto, H., Sakurai, S., & Aizawa, T. (2012) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.13334 · Cited by 11 · see citing works
Dietary Intake of Energy and Nutrients from Breakfast and Risk of Stroke in The Japanese Population: The Circulatory Risk in Communities Study (CIRCS)
Okada, C., Imano, H., Yamagishi, K., Cui, R., Umesawa, M., Maruyama, K., Muraki, I., Hayama‐Terada, M., Shimizu, Y., Sankai, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.44438 · Cited by 9 · see citing works
Self-citation
The predictive value of triglyceride-glucose index combined with non–high-density lipoprotein cholesterol in coronary heart disease
Zhang, C., Zhang, H., Yang, Z., Yao, S., & Ji, N. (2025) · BMC Cardiovascular Disorders · doi:10.1186/s12872-024-04410-z · Cited by 7 · see citing works
Subclass distribution of low‐density lipoprotein triglyceride and the clustering of metabolic syndrome components in Japanese children
Tonouchi, R., Okada, T., Abe, Y., Kazama, M., Kuromori, Y., Yoshino, Y., Iwata, F., Hara, M., Saito, E., & Morioka, I. (2020) · Pediatrics International · doi:10.1111/ped.14490 · Cited by 7 · see citing works
Self-citation
Predictive value of non-HDL cholesterol for cardiovascular disease in a population in far western Algeria with type 2 diabetes
Kachekouche, Y., Dali-Sahi, M., Bendaoud, R., Dennouni-Medjati, N., & Abderahim, M. (2018) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2018.12.002 · Cited by 3 · see citing works
Association of Elevated Non-HDL-C and LDL-C with Carotid atherosclerosis among Tibetans Living at High Altitudes: A Cross-sectional StudyPreprint
Hu, X., Zhang, X., Gou, Q., Ye, R., Zhang, Z., Li, X., & Chen, X. (2022) · Research Square · doi:10.21203/rs.3.rs-1228533/v1 · Cited by 2 · see citing works
Importance and Management of Non–High-Density Lipoprotein Cholesterol in Dyslipidemia Treatment
O’Brien, R. C., Santos, L. E. G., Tomlinson, B., Hussein, Z. B., Lim, S., Nawawi, H. M., Ong, H. Y., Silki, S., Soegondo, S., Su, T., et al. (2026) · JACC Asia · doi:10.1016/j.jacasi.2025.12.024 · Cited by 2 · see citing works
Combined Effects of Plant Sterols with Low Ratio of n-6/n-3 Polyunsaturated Fatty Acids against Atherosclerosis in ApoE–/– Mice
Chen, C., Lü, L., Qin, Y., Lv, C., Wan, X., & Guo, X. (2020) · Current Medical Science · doi:10.1007/s11596-020-2292-z · Cited by 1 · see citing works
Equisetum sylvaticum base reduces atherosclerosis risk factors in rats fed a high-fat diet
Lin, C., Xu, H., Sun, W.-L., Li, F., & Lin, G. (2014) · Bangladesh Journal of Pharmacology · doi:10.3329/bjp.v9i3.18593 · Cited by 1 · see citing works
The effects of herring-roe lyophilized powder on lipid metabolism
Nishimura, M., Ohkawara, T., Kobayashi, H., Sato, Y., Munekata, M., & Nishihira, J. (2015) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2015.04.002 · Cited by 1 · see citing works
The Serum Lipid Lowering Effect of Rugosa Rose Petal Extract Rich in Polyphenols in Adults with High Serum Triglyceride
Yamagishi, T., TAKANO, K., & Sumio, K. (2015) · Japanese Journal of Complementary and Alternative Medicine · doi:10.1625/jcam.12.29 · Cited by 1 · see citing works
Association of Elevated Non-HDL-C and LDL-C with Carotid Atherosclerosis among Tibetans Living at High Altitudes: A Cross-sectional StudyPreprint
Hu, X., Zhang, X., Gou, Q., Ye, R., Zhang, Z., Li, X., & Chen, X. (2021) · Research Square · doi:10.21203/rs.3.rs-1183161/v1 · Cited by 1 · see citing works
A cross-sectional study on the relationship between serum lipid concentrations and sleeping habits in middle-age and elderly men
Kasamaki, J., Miyanishi, K., & Yamazaki, K. (2016) · doi:10.32269/hbs.14.2_75
Association between 25 Hydroxyvitamin D Concentrations and Lipid Profiles in Japanese with Type 2 Diabetes Mellitus
Bando, H., Taneda, S., & Manda, N. (2021) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.67.266
Non-High-Density Lipoprotein Cholesterol and Risk of Cardiovascular Events: A Systematic Review and Meta-AnalysisPreprint
Li, Z., Hu, X., Chen, Y., Li, A., Zhang, Z., Li, Y., Yuan, H., & Lu, Y. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4112147
Relation Between Outpatient Medical Expenses and Self-Rated Health in Patients With Hypertension, Dyslipidemia, and Diabetes Mellitus Covered by National Health InsurancePreprint
Kawasaki, S., Ohnishi, M., Nakao, R., Kosaka, S., & Kawasaki, R. (2024) · Research Square · doi:10.21203/rs.3.rs-4471292/v1

Association between Non-High-Density Lipoprotein Cholesterol Concentrations and Mortality from Coronary Heart Disease Among Japanese Men and Women: The Ibaraki Prefectural Health Study
Noda, H., Iso, H., Irie, F., Sairenchi, T., Ohtaka, E., & Ohta, H. (2010) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.1016 · Cited by 32 · see citing works
Self-citation
Low-density lipoprotein cholesterol and risk of coronary heart disease among Japanese men and women: The Circulatory Risk in Communities Study (CIRCS)
Imano, H., Noda, H., Kitamura, A., Sato, S., Kiyama, M., Sankai, T., Ohira, T., Nakamura, M., Yamagishi, K., Ikeda, A., et al. (2011) · Preventive Medicine · doi:10.1016/j.ypmed.2011.02.019 · Cited by 97 · see citing works
Self-citation
Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population: The Hisayama Study
Imamura, T., Doi, Y., Ninomiya, T., Hata, J., Nagata, M., Ikeda, F., Mukai, N., Hirakawa, Y., Yoshida, D., Fukuhara, M., et al. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.01.005 · Cited by 47 · see citing works
Non-High-Density Lipoprotein Cholesterol and Risk of Cardiovascular Disease: The Japan Epidemiology Collaboration on Occupational Health Study
Hu, H., Fukunaga, A., Yokoya, T., Nakagawa, T., Honda, T., Yamamoto, S., Okazaki, H., Miyamoto, T., Sasaki, N., Ogasawara, T., et al. (2021) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.63118 · Cited by 29 · see citing works
Meta-analysis of serum non-high-density lipoprotein cholesterol and risk of coronary heart disease in the general population
Liu, H., Deng, X., Peng, Y., Zeng, Q., Song, Z., He, W., Zhang, L., Gao, G., Xiao, T., & Yu, X. (2017) · Clinica Chimica Acta · doi:10.1016/j.cca.2017.05.006 · Cited by 28 · see citing works

Authors: Kitamura, A., Noda, H., Nakamura, M., Kiyama, M., Okada, T., Imano, H., Ohira, T., Sato, S., Yamagishi, K., & Iso, H.
Affiliations: Osaka University Hospital (JP)
The University of Osaka (JP)
Chiba Prefectural Institute of Public Health (JP)
University of Tsukuba (JP)
ORCID: Kitamura, Akihiko
Noda, Hiroyuki
Nakamura, Masakazu
Kiyama, Masahiko
Okada, Takeo
Imano, Hironori
Ohira, Tetsuya
Sato, Shinichi
Yamagishi, Kazumasa
Iso, Hiroyasu
Venue: Journal of Atherosclerosis and Thrombosis
Publisher: Japan Atherosclerosis Society
Published: 2011
Volume: 18
Issue: 6
Pages: 454-463
ISSN: 1340-3478 (ISSN-L)
1880-3873
DOI: 10.5551/jat.7237
OpenAlex: W2071214196
Cited by: 51
References: 25
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 5 · 2015: 7 · 2014: 5 · 2013: 6 · 2012: 5
FWCI: 5.23
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
Locations: Journal of Atherosclerosis and Thrombosis (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Funders: Japan Society for the Promotion of Science (21390214)
Topics: Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords: non-HDL cholesterol, coronary artery disease, cut-off values, Japanese adults, Circulatory Risk in Communities Study, dyslipidemia, cardiovascular disease incidence
MeSH terms: Adult, Aged, Coronary Disease, Female, Humans, Japan, Lipoproteins, HDL, Cholesterol, LDL, Male, Middle Aged, Predictive Value of Tests, Retrospective Studies, Risk Factors, Cholesterol, VLDL, Incidence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Association between Non-High-Density Lipoprotein Cholesterol Levels and the Incidence of Coronary Heart Disease among Japanese: The Circulatory Risk in Communities Study (CIRCS)

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks