Small LDL-Cholesterol is Superior to LDL-Cholesterol for Determining Severe Coronary Atherosclerosis
Open accessAbstract
AIM: Recent evidence suggests that small dense low-density lipoprotein (sd-LDL) particles are more atherogenic than large-LDL in spite of their lower cholesterol content. This study aimed to determine whether sd-LDL-cholesterol (sd-LDL-C) is superior to LDL-C as a biomarker of coronary heart disease (CHD). METHODS: LDL particle size determined by gradient gel electrophoresis and sd-LDL-C concentrations quantified by heparin-magnesium precipitation were compared between 482 stable CHD patients and 389 non-diabetic subjects without CHD who were not receiving any lipid-lowering drugs. RESULTS: Both male and female CHD patients had significantly smaller LDL particles and lower large-LDL-C concentrations (estimated by subtracting the sd-LDL-C concentration from the LDL-C concentration), and significantly higher sd-LDL-C concentrations than the control subjects. LDL-C concentrations were modestly higher and sd-LDL-C concentrations were significantly higher in 258 patients with angiographically documented severe CHD than in the patients with mild CHD irrespective of treatment by LDL-lowering drugs and history of myocardial infarction and/or coronary revascularization. Large-LDL-C concentrations, in contrast, were similar between the two groups. Multivariate logistic regression analysis revealed that sd-LDL-C levels were significantly associated with severe CHD independently of LDL-C. CONCLUSION: sd-LDL-C levels are more powerful than LDL-C levels for the determination of severe stable CHD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Small dense LDL levels are increased in conditions such as type 2 DM, metabolic syndrome, and insulin resistance.
“In addition, its levels are increased in conditions such as type 2 DM, metabolic syndrome, and insulin resistance259, 267).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [259]
Small dense LDL is closely associated with hypertriglyceridemia and hypo-HDL cholesterolemia.
“Small dense LDL is closely associated with hypertriglyceridemia and hypo-HDL cholesterolemia259, 266).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [259]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Grundy, S. M., Cleeman, J. I., Merz, C. N. B., Brewer, H. B., Clark, L. T., Hunninghake, D. B., Pasternak, R. C., Smith, S. C., & Stone, N. J. (2004) · Circulation · doi:10.1161/01.cir.0000133317.49796.0e · Cited by 6,902 · see citing works
Ridker, P. M., Rifai, N., Rose, L., Buring, J. E., & Cook, N. R. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021993 · Cited by 3,604 · see citing works
A more meaningful scoring system for determining the severity of coronary heart disease
Gensini, G. G. (1983) · The American Journal of Cardiology · doi:10.1016/s0002-9149(83)80105-2 · Cited by 2,171 · see citing works
Statin Therapy, LDL Cholesterol, C-Reactive Protein, and Coronary Artery Disease
Nissen, S. E., Tuzcu, E. M., Schoenhagen, P., Crowe, T., Sasiela, W. J., Tsai, J., Orazem, J., Magorien, R. D., O'Shaughnessy, C., & Ganz, P. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042000 · Cited by 1,325 · see citing works
Walldius, G., Jungner, I., Holme, I., AASTVEIT, A. H., Kolar, W., & Steiner, E. (2001) · The Lancet · doi:10.1016/s0140-6736(01)07098-2 · Cited by 1,227 · see citing works
Inflammatory Markers and the Risk of Coronary Heart Disease in Men and Women
Pai, J. K., Pischon, T., Ma, J., Manson, J. E., Hankinson, S. E., JOSHIPURA, K. J., Curhan, G. C., Rifai, N., Cannuscio, C. C., Stampfer, M. J., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040967 · Cited by 1,174 · see citing works
Metabolic origins and clinical significance of LDL heterogeneity
Berneis, K. K., & Krauss, R. M. (2002) · Journal of Lipid Research · doi:10.1194/jlr.r200004-jlr200 · Cited by 896 · see citing works
Gardner, C. D. (1996) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1996.03540110029028 · Cited by 843 · see citing works
Roberts, W. L., Moulton, L., Law, T. C., Farrow, G., Cooper-Anderson, M., Savory, J., & Rifai, N. (2001) · Clinical Chemistry · doi:10.1093/clinchem/47.3.418 · Cited by 652 · see citing works
[24] Nondenaturing polyacrylamide gradient gel electrophoresis
Nichols, A. V., Krauss, R. M., & Musliner, T. A. (1986) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(86)28084-2 · Cited by 522 · see citing works
Pischon, T., Girman, C. J., Sacks, F. M., Rifai, N., Stampfer, M. J., & Rimm, E. B. (2005) · Circulation · doi:10.1161/circulationaha.104.532499 · Cited by 514 · see citing works
Apolipoproteins versus lipids as indices of coronary risk and as targets for statin treatment
Sniderman, A. D., Furberg, C. D., KEECH, A. C., van Lennep, J. R., Frohlich, J., Jungner, I., & Walldius, G. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12663-3 · Cited by 457 · see citing works
St-Pierre, A. C., Cantin, B., Dagenais, G. R., Mauriège, P., Bernard, P.-M., Després, J.-P., & Lamarche, B. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000154144.73236.f4 · Cited by 422 · see citing works
Mora, S., Szklo, M., Otvos, J. D., Greenland, P., Psaty, B. M., Goff, D. C., O’Leary, D. H., Saad, M. F., Tsai, M. Y., & Sharrett, A. R. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.05.007 · Cited by 380 · see citing works
PHILLIPS, N. R., Waters, D. D., & Havel, R. J. (1993) · Circulation · doi:10.1161/01.cir.88.6.2762 · Cited by 345 · see citing works
Increased Small Low-Density Lipoprotein Particle Number
Kathiresan, S., Otvos, J. D., SULLIVAN, L. M., Keyes, M. J., Schaefer, E. J., Wilson, P. W. F., D’Agostino, R. B., Vasan, R. S., & Robins, S. J. (2005) · Circulation · doi:10.1161/circulationaha.105.567107 · Cited by 317 · see citing works
Blankenhorn, D. H., Alaupovic, P., Wickham, E., Chin, H. P., & Azen, S. P. (1990) · Circulation · doi:10.1161/01.cir.81.2.470 · Cited by 278 · see citing works
Lipoprotein predictors of the severity of coronary artery disease in men and women.
Reardon, M. F., Nestel, P. J., Craig, I. H., & Harper, R. W. (1985) · Circulation · doi:10.1161/01.cir.71.5.881 · Cited by 266 · see citing works
Severity of coronary atherosclerosis related to lipoprotein concentration.
Jenkins, P. J., Harper, R. W., & Nestel, P. J. (1978) · BMJ · doi:10.1136/bmj.2.6134.388 · Cited by 255 · see citing works
TATAMI, R., Mabuchi, H., Ueda, K., Ueda, R., Haba, T., KAMETANI, T., Ito, S., Koizumi, J., Ohta, M., Miyamoto, S., et al. (1981) · Circulation · doi:10.1161/01.cir.64.6.1174 · Cited by 246 · see citing works
A novel and simple method for quantification of small, dense LDL
Hirano, T., Ito, Y., Saegusa, H., & Yoshino, G. (2003) · Journal of Lipid Research · doi:10.1194/jlr.d300007-jlr200 · Cited by 192 · see citing works
Self-citationGardner, C. D. (1996) · JAMA · doi:10.1001/jama.276.11.875 · Cited by 188 · see citing works
Lipoprotein atherogenicity: an overview of current mechanisms
Griffin, B. A. (1999) · Proceedings of The Nutrition Society · doi:10.1079/pns19990022 · Cited by 182 · see citing works
Tornvall, P., Karpe, F., Carlson, L. A., & Hamsten, A. (1991) · Atherosclerosis · doi:10.1016/0021-9150(91)90245-x · Cited by 147 · see citing works
Measurement of Small Dense Low-density Lipoprotein Particles
Hirano, T., Ito, Y., & Yoshino, G. (2005) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.12.67 · Cited by 137 · see citing works
Self-citationHirano, T., Ito, Y., Koba, S., Toyoda, M., Ikejiri, A., Saegusa, H., Yamazaki, J., & Yoshino, G. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000117179.92263.08 · Cited by 129 · see citing works
Self-citationKoba, S., Hirano, T., Ito, Y., Tsunoda, F., Yokota, Y., Ban, Y., Iso, Y., Suzuki, H., & Katagiri, T. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.12.002 · Cited by 121 · see citing works
Self-citationLipids and CVD management: towards a global consensus
Ballantyne, C. M., Arroll, B., & Shepherd, J. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi373 · Cited by 86 · see citing works
Early Time to Benefit with Intensive Statin Treatment: Could It Be the Pleiotropic Effects?
Ray, K. K., & Cannon, C. P. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.06.027 · Cited by 81 · see citing works
Koba, S., Hirano, T., Kondo, T., Shibata, M., Suzuki, H., Murakami, M., Geshi, E., & Katagiri, T. (2002) · American Heart Journal · doi:10.1067/mhj.2002.126119 · Cited by 73 · see citing works
Self-citationHow, when, and why to use apolipoprotein B in clinical practice
Sniderman, A. D. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02633-4 · Cited by 66 · see citing works
Tokuno, A., Hirano, T., Hayashi, T., Mori, Y., Yamamoto, T., Nagashima, M., Shiraishi, Y., Ito, Y., & Adachi, M. (2007) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.14.128 · Cited by 65 · see citing works
Self-citationAi, M., Otokozawa, S., Asztalos, B. F., Nakajima, K., Stein, E. A., Jones, P. H., & Schaefer, E. J. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.08.035 · Cited by 60 · see citing works
Sakaue, T., Hirano, T., Yoshino, G., Sakai, K., Takeuchi, H. T., & Adachi, M. (2000) · Clinica Chimica Acta · doi:10.1016/s0009-8981(00)00200-x · Cited by 50 · see citing works
Self-citationMaas, R., Quitzau, K., Schwedhelm, E., Spieker, L. E., Rafflenbeul, W., Steenpaß, A., Lüscher, T. F., & Böger, R. H. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.03.024 · Cited by 45 · see citing works
Increased ApoB in Small Dense LDL Particles Predicts Premature Coronary Artery Disease
Brunzell, J. D. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000156537.78366.1d · Cited by 32 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Saito Y: The Japan Atherosclerosis Society Guidelines for Diagnosis and Treatment of Atherosclerotic Cardiovascu- lar Disease 2002 (Editorial). J Atheroscler Thromb, 2004; 11:101-103
- Nichols AV, Krauss RM, and Musliner TA: Nondenatur- ing polyacrylamide gradient gel electrophoresis. Methods Enzymol, 1986; 128:417-431
Cited by
Sorted by citations
Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813 · see citing works
Self-citationOkamura, T., Tsukamoto, K., Arai, H., Fujioka, Y., Ishigaki, Y., Koba, S., Ohmura, H., Shoji, T., Yokote, K., Yoshida, H., et al. (2023) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2022 · Cited by 317 · see citing works
Self-citationIkezaki, H., Lim, E., Cupples, L. A., Liu, C., Asztalos, B. F., & Schaefer, E. J. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.019140 · Cited by 192 · see citing works
Tsai, M. Y., Steffen, B. T., Guan, W., McClelland, R. L., Warnick, R., McConnell, J. P., Hoefner, D. M., & Remaley, A. T. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.302401 · Cited by 183 · see citing works
Nikolić, D., Katsiki, N., Montalto, G., Isenović, E. R., Mikhailidis, D. P., & Rizzo, M. (2013) · Nutrients · doi:10.3390/nu5030928 · Cited by 160 · see citing works
Arai, H., Kokubo, Y., Watanabe, M., Sawamura, T., Ito, Y., Minagawa, A., Okamura, T., & Miyamato, Y. (2012) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.14936 · Cited by 134 · see citing works
Self-citationLiou, L., & Kaptoge, S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241993 · Cited by 118 · see citing works
Zunino, S. J., Parelman, M. A., Freytag, T. L., Stephensen, C. B., Kelley, D. S., Mackey, B. E., Woodhouse, L. R., & Bonnel, E. L. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511006027 · Cited by 116 · see citing works
The role of nutraceuticals in the prevention of cardiovascular disease
Sosnowska, B., Penson, P. E., & Banach, M. (2017) · Cardiovascular Diagnosis and Therapy · doi:10.21037/cdt.2017.03.20 · Cited by 113 · see citing works
Partsalaki, Karvela, A., & Spiliotis, B. E. (2012) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2012-0131 · Cited by 107 · see citing works
Nishikura, T., Koba, S., Yokota, Y., Hirano, T., Tsunoda, F., Shoji, M., Hamazaki, Y., Suzuki, H., Itoh, Y., Katagiri, T., et al. (2014) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.23465 · Cited by 88 · see citing works
Self-citationJin, J.-L., Zhang, H.-W., Cao, Y.-X., Liu, H.-H., Hua, Q., Li, Y.-F., Zhang, Y., Wu, N.-Q., Zhu, C.-G., Xu, R.-X., et al. (2020) · Cardiovascular Diabetology · doi:10.1186/s12933-020-01015-6 · Cited by 82 · see citing works
Associations of perfluoroalkyl substances (PFAS) with lipid and lipoprotein profiles
Haug, M., Dunder, L., Lind, P., Lind, L., & Salihović, S. (2023) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-023-00545-x · Cited by 81 · see citing works
Ferri, N., & Ruscica, M. (2016) · Endocrine · doi:10.1007/s12020-016-0939-0 · Cited by 79 · see citing works
A High Legume Low Glycemic Index Diet Improves Serum Lipid Profiles in Men
Zhang, Z., Lanza, E., Kris‐Etherton, P. M., Colburn, N. H., Bagshaw, D., Rovine, M. J., Ulbrecht, J. S., Bobe, G., Chapkin, R. S., & Hartman, T. J. (2010) · Lipids · doi:10.1007/s11745-010-3463-7 · Cited by 78 · see citing works
Zunino, S. J., Peerson, J. M., Freytag, T. L., Breksa, A. P., Bonnel, E. L., Woodhouse, L. R., & Storms, D. H. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514000890 · Cited by 74 · see citing works
Fan, J., Liu, Y., Yin, S., Chen, N., Bai, X., Ke, Q., Shen, J., & Xia, M. (2019) · Nutrition & Metabolism · doi:10.1186/s12986-019-0334-y · Cited by 74 · see citing works
Lipid and lipoprotein abnormalities in acute lymphoblastic leukemia survivors
Morel, S., Leahy, J., Fournier, M., Lamarche, B., Garofalo, C., Grimard, G., Poulain, F., DELVIN, E. E., Laverdière, C., Krajinović, M., et al. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m072207 · Cited by 62 · see citing works
Roehl, K., Falco-Walter, J. J., Ouyang, B., & Balabanov, A. J. (2019) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2018.12.010 · Cited by 51 · see citing works
Method for estimating high sdLDL-C by measuring triglyceride and apolipoprotein B levels
Hayashi, T., Koba, S., Ito, Y., & Hirano, T. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0417-6 · Cited by 50 · see citing works
Self-citationSekimoto, T., Koba, S., Mori, H., Sakai, R., Arai, T., Yokota, Y., Sato, S., Tanaka, H., Masaki, R., Oishi, Y., et al. (2021) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.60152 · Cited by 46 · see citing works
Self-citationPhelan, N., O’Connor, A. S., Tun, T. K., Correia, N., Boran, G. P., Roche, H. M., & Gibney, J. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2444 · Cited by 46 · see citing works
Sidhwani, S., Scoccia, B., Sunghay, S., Stephens, C. N., Mazzone, T., & Sam, S. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04015.x · Cited by 43 · see citing works
Nishikido, T., Oyama, J., Keida, T., Ohira, H., & Node, K. (2015) · Journal of Cardiology · doi:10.1016/j.jjcc.2015.05.017 · Cited by 40 · see citing works
López‐Domènech, S., Martínez-Herrera, M., Abad‐Jiménez, Z., Morillas, C., Escribano‐López, I., Díaz‐Morales, N., Bañuls, C., Víctor, V. M., & Rocha, M. (2019) · International Journal of Obesity · doi:10.1038/s41366-018-0309-5 · Cited by 39 · see citing works
Sakai, K., Koba, S., Nakamura, Y., Yokota, Y., Tsunoda, F., Shoji, M., Itoh, Y., Hamazaki, Y., & Kobayashi, Y. (2018) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.13287 · Cited by 36 · see citing works
Self-citationSchaefer, E. J., Ikezaki, H., Diffenderfer, M. R., Lim, E., Liu, C., Hoogeveen, R. C., Guan, W., Tsai, M. Y., & Ballantyne, C. M. (2023) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2023.01.015 · Cited by 37 · see citing works
Hernández‐Mijares, A., Jover, A., Bellod, L., Bañuls, C., Solá, E., Veses, S., Víctor, V. M., & Rocha, M. (2012) · Clinical Endocrinology · doi:10.1111/cen.12064 · Cited by 36 · see citing works
Small Dense Low-Density Lipoprotein Cholesterol and Carotid Intimal Medial Thickness Progression
Ikezaki, H., Furusyo, N., Yokota, Y., Ai, M., Asztalos, B. F., Murata, M., Hayashi, J., & Schaefer, E. J. (2020) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.54130 · Cited by 36 · see citing works
Self-citationLipoprotein Subfractions and Glucose Homeostasis in Prediabetes and Diabetes in Taiwan
Hsu, H., Hsu, P.-W., Cheng, M., Ito, Y., Kanda, E., Schaefer, E. J., & Ai, M. (2019) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.48330 · Cited by 35 · see citing works
Self-citationAtherogenic Lipoproteins for the Statin Residual Cardiovascular Disease Risk
Yanai, H., Adachi, H., Hakoshima, M., & Katsuyama, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113499 · Cited by 35 · see citing works
Rocha, M., Bañuls, C., Bellod, L., Rovira‐Llopis, S., Morillas, C., Solá, E., Víctor, V. M., & Hernández‐Mijares, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078670 · Cited by 35 · see citing works
Kikkawa, K., Nakajima, K., Shimomura, Y., Tokita, Y., Machida, T., Sumino, H., & Murakami, M. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.07.017 · Cited by 33 · see citing works
Fukushima, Y., Hirayama, S., Ueno, T., Dohi, T., Miyazaki, T., Ohmura, H., Mokuno, H., Miyauchi, K., Miida, T., & Daida, H. (2011) · Clinica Chimica Acta · doi:10.1016/j.cca.2011.04.021 · Cited by 32 · see citing works
Hirano, T. (2025) · Journal of Diabetes Investigation · doi:10.1111/jdi.14398 · Cited by 31 · see citing works
Self-citationShen, H., Xu, Y., Lu, J., Ma, C., Zhou, Y., Li, Q., Chen, X., Zhu, A., & Shen, G. (2016) · BMC Nephrology · doi:10.1186/s12882-016-0358-8 · Cited by 29 · see citing works
Bañuls, C., Rovira‐Llopis, S., Falcón, R., Veses, S., Monzó, N., Víctor, V. M., Rocha, M., & Hernández‐Mijares, A. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.05.005 · Cited by 29 · see citing works
Beebe, N., Magnanti, S., Katkowski, L., Benson, M. C., Xu, F., Delmonico, M. J., & Lofgren, I. E. (2013) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2012.0531 · Cited by 29 · see citing works
Zhang, Y., Xu, R., Li, S., Zhu, C.-G., Guo, Y.-L., Sun, J., & Li, J. (2015) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.01.006 · Cited by 28 · see citing works
Zhao, X., Sun, D., Xu, R., Guo, Y., Zhu, C., Wu, N., Zhang, Y., Li, S., Gao, Y., Liu, G., et al. (2018) · Biomarkers · doi:10.1080/1354750x.2018.1474256 · Cited by 27 · see citing works
Current pharmacotherapeutic concepts for the treatment of cardiovascular disease in diabetics
Highlander, P. D., & Shaw, G. P. (2009) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944709354305 · Cited by 25 · see citing works
Zhang, J., & He, L. (2021) · BMC Cardiovascular Disorders · doi:10.1186/s12872-021-01979-7 · Cited by 23 · see citing works
Zhu, C., Zhang, Y., Xu, R., Li, S., Wu, N., Guo, Y., Sun, J., & Li, J. (2015) · Journal of clinical lipidology · doi:10.1016/j.jacl.2015.08.010 · Cited by 23 · see citing works
Hosoyamada, K., Uto, H., Imamura, Y., Hiramine, Y., Toyokura, E., Hidaka, Y., Kuwahara, T., Kusano, K., Saito, K., Oketani, M., et al. (2012) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-4-34 · Cited by 21 · see citing works
Ning, H., Huang, Y.-C., Chang, P.-Y., & Hwang, J. (2014) · Biomedical Journal · doi:10.4103/2319-4170.132883 · Cited by 20 · see citing works
Influence of obesity on atherogenic dyslipidemia in women with polycystic ovary syndrome
Hernández‐Mijares, A., Bañuls, C., Gómez‐Balaguer, M., Bergoglio, M. T., Víctor, V. M., & Rocha, M. (2013) · European Journal of Clinical Investigation · doi:10.1111/eci.12080 · Cited by 18 · see citing works
Association of serum 25-Hydroxy Vitamin D level with lipid, lipoprotein, and apolipoprotein level
Elmi, C. P., Fan, M. M., Le, M., Cheng, G., & Khalighi, K. (2021) · Journal of Community Hospital Internal Medicine Perspectives · doi:10.1080/20009666.2021.1968571 · Cited by 17 · see citing works
Aoki, T., Yagi, H., Sumino, H., Tsunekawa, K., Araki, O., Kimura, T., Nara, M., Ogiwara, T., Nakajima, K., & Murakami, M. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.01.010 · Cited by 17 · see citing works
Zhang, H., Jin, J., Cao, Y., Liu, H., Zhang, Y., Guo, Y., Wu, N., Zhu, C., Gao, Y., Xu, R., et al. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002678 · Cited by 17 · see citing works
LeCheminant, J. D., SMITH, B. K., Westman, E. C., Vernon, M. C., & Donnelly, J. E. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-54 · Cited by 17 · see citing works
Filler, G., Taheri, S., McIntyre, C. W., Smith, C., Subramanian, L., Fusch, G., & Fusch, C. (2017) · Clinical Kidney Journal · doi:10.1093/ckj/sfx115 · Cited by 17 · see citing works
Observational study of lipid profile and LDL particle size in patients with metabolic syndrome
Sancho‐Rodríguez, N., Avilés-Plaza, F. V., Fernández, E. G., Hernández-Martínez, A. M., Albaladejo-Otón, M. D., Martínez-Mernández, P., & Pallarés, S. P. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-162 · Cited by 16 · see citing works
Modeling cholesterol metabolism and atherosclerosis
Auley, M. T. M. (2021) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1546 · Cited by 16 · see citing works
Nomura, S. J. O., Karger, A. B., Garg, P. K., Cao, J., Bhatia, H. S., Duran, E. K., Duprez, D. A., Guan, W., & Tsai, M. Y. (2022) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2022.100436 · Cited by 15 · see citing works
Rikhi, R. R., Schaich, C. L., Hafzalla, G. W., Patel, N. A., Tannenbaum, J., German, C. A., Polonsky, T. S., Tsai, M. Y., Ahmad, M. I., Islam, T., et al. (2024) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwae049 · Cited by 15 · see citing works
Takahashi, R., Imamura, A., Yoshikane, M., Suzuki, M., Murakami, R., Cheng, X. W., Numaguchi, Y., Ikeda, N., Murohara, T., & Okumura, K. (2010) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.5272 · Cited by 14 · see citing works
Takagi, H., Niwa, M., Mizuno, Y., Yamamoto, H., Goto, S.-N., & Umemoto, T. (2013) · Heart and Vessels · doi:10.1007/s00380-013-0358-6 · Cited by 13 · see citing works
Liu, J., Yang, R., Zhou, M., Wen, M., Li, H., Zhao, H., Wang, S., Chen, W., Dong, J., & He, Q. W. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0545-z · Cited by 13 · see citing works
on behalf of the Samurai Study Investigators, Okumura, K., Tsukamoto, H., Tsuboi, H., Hirayama, H., Kamiya, H., Watarai, M., Ishiki, R., & Murohara, T. (2014) · Heart and Vessels · doi:10.1007/s00380-013-0466-3 · Cited by 11 · see citing works
Tanaka, M., Hayashi, N., & Iida, T. (2019) · Fundamental Toxicological Sciences · doi:10.2131/fts.6.225 · Cited by 11 · see citing works
One-Year Clinical Outcomes among Patients with Metabolic Syndrome and Acute Myocardial Infarction
Ji, M. S., Jeong, M. H., Ahn, Y., Kim, Y. J., Chae, S. C., Hong, T. J., Seong, I. W., Chae, J. K., Kim, C. J., Cho, M., et al. (2013) · Korean Circulation Journal · doi:10.4070/kcj.2013.43.8.519 · Cited by 9 · see citing works
Balling, M., Nordestgaard, B. G., Langsted, A., Varbo, A., Kamstrup, P. R., & Afzal, S. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf305 · Cited by 6 · see citing works
Yoshino, G., Nakano, S., Matsumoto, T., Murakami, E., Morita, T., & Kuboki, K. (2012) · Pharmacology & Pharmacy · doi:10.4236/pp.2012.31011 · Cited by 6 · see citing works
Rocha, M., Bañuls, C., Bellod, L., Rovira‐Llopis, S., Morillas, C., Solá, E., VÃctor, V. M., & Mijares, A. H. (2013) · PLoS ONE · doi:10.1371/annotation/4ee4f5f7-519f-402c-8ed2-dff0cc6c5e48 · Cited by 6 · see citing works
Haapala, E. A., Leppänen, M. H., Lehti, M., Lintu, N., Tompuri, T., Viitasalo, A., Schwab, U., & Lakka, T. A. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.954418 · Cited by 5 · see citing works
Berg, A., Petrole, R. F., Li, H., Sorokin, A. V., González‐Cantero, Á., Playford, M. P., Mehta, N. N., & Teague, H. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1041457 · Cited by 5 · see citing works
Vaverková, H. (2011) · Clinical Lipidology · doi:10.2217/clp.10.75 · Cited by 5 · see citing works
Nuts and not olive oil decrease small and dense LDL: Results from the PREDIMED Study
Zampelas, A. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.07.058 · Cited by 4 · see citing works
Association of lipoprotein subclasses and carotid intima-media thickness in the Chinese population
Yan, F., Tian, L., Yu, H., Baskota, A., Gao, Y., Li, S., Fu, M., & Tian, H. (2014) · Clinical Lipidology · doi:10.2217/clp.14.22 · Cited by 4 · see citing works
Guo, G., Cheng, X., & Fu, R. (2014) · Current Therapeutic Research · doi:10.1016/j.curtheres.2013.11.006 · Cited by 4 · see citing works
Alabakovska, S. B., Trajkovska, K. T., Spiroski, M. Z., A, M., Jovanova, S., & Labudović, D. D. (2012) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2012_020 · Cited by 4 · see citing works
Гаврилова, Н. Е., Metelskaya, V. A., Николаевна, О. И., Yarovaya, E. B., & Boytsov, S. A. (2016) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2016-10-64-70 · Cited by 3 · see citing works
Evolocumab Effects on Lipoproteins, Measured by High-Performance Liquid Chromatography
Masuda, D., Kiyosue, A., Hirayama, A., Shimauchi, J., López, J. A. G., Miyawaki, K., & Yamashita, S. (2020) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.54353 · Cited by 3 · see citing works
Cholesterol transport in blood, lipoproteins, and cholesterol metabolism
Auley, M. T. M., & Morgan, A. E. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85857-1.00025-0 · Cited by 3 · see citing works
Association of sleep duration and quality with small dense low-density lipoprotein cholesterol
Yamada, T., Yamamoto, Y., Toragai, R., Watanabe, Y., Kuroshima, T., Arimoto, M., Nakamura, M., Ito, Y., & Ai, M. (2026) · Journal of clinical lipidology · doi:10.1016/j.jacl.2025.12.020 · Cited by 2 · see citing works
Self-citationLuna, J. G. C., García, M. B., Otón, M. D. A., Fernández, E. G., Martínez, A. M. H., & Pallarés, S. P. (2009) · Revista del Laboratorio Clínico · doi:10.1016/j.labcli.2009.07.005 · Cited by 2 · see citing works
Quantitative Influence of Exogenous Androgens on Serum Lipid Profile and Endocrine Functions
Gårevik, N. (2013) · Figshare · Cited by 2 · see citing works
Ji, C., Wang, R., Wang, D., Luo, Y., Huang, Z., Liu, J., & Cheng, A. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.103607 · Cited by 1 · see citing works
Kang, D., Yang, H., Park, K. W., Lee, S., Lee, M., Lee, D.-W., Lee, H., Kang, H., Koo, B., Chae, I., et al. (2012) · Korean Circulation Journal · doi:10.4070/kcj.2012.42.8.551 · Cited by 1 · see citing works
GENDER SPECIFICS OF SUBFRACTIONAL PLASMA LIPOPROTEIDS DISTRIBUTION
Николаевна, О. И., Metelskaya, V. A., & Гаврилова, Н. Е. (2016) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2016-4-70-74 · Cited by 1 · see citing works
Zhang, F., Zhang, Y., Zhang, J., Wang, X., Li, Y., & Wang, W. (2024) · PLoS ONE · doi:10.1371/journal.pone.0298070 · Cited by 1 · see citing works
新治, 木. (2011) · 心臓 · doi:10.11281/shinzo.43.444 · Cited by 1 · see citing works
Smith, F., & Faydenko, J. (2020) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2020.101135 · Cited by 1 · see citing works
High Density Lipoproteins, Dyslipidemia, and Heart Disease: Past, Present, and Future
Schaefer, E. J., & Santos, R. D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1059-2_23 · Cited by 1 · see citing works
Hu, C., Han, H., Sun, Y., Cheng, Y., Liu, Y., Liu, J., Gao, A., Zhou, Y., Zhang, J., & Zhao, Y. (2020) · doi:10.21203/rs.3.rs-81372/v1 · Cited by 1 · see citing works
Estudo bioquímico e molecular de famílias com hipercolesterolemia familiar
Leitão, F. R. G. (2012) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Tsuzaki, K., Kotani, K., Yamada, K., Sano, Y., Matsuoka, Y., OKAZAKI, K., Yamada, T., Shimatsu, A., & Sakane, N. (2009) · Journal of Electrophoresis · doi:10.2198/jelectroph.53.39
Kim, W. J., Lee, C. B., Park, C., Park, S. E., Rhee, E., Lee, W., Oh, K. W., Park, S. W., Kim, D. J., Kim, H. J., et al. (2009) · Korean Diabetes Journal · doi:10.4093/kdj.2009.33.6.494
Lipids and autoimmunity in atherosclerosis and cardiovascular diseases
Xiang, H. (2009) · Figshare
LOW-DENSITY LIPOPROTEIN SUBFRACTIONS AND VARYING DEGREE OF CORONARY STENOSIS
Николаевна, О. И., Nv, P., Metelskaya, V. A., Chernushevich, O., & Гаврилова, Н. Е. (2013) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2013-4-16-20
Ma, K.-L., Liu, Y., Lian, H., Sun, L., Liu, C., & Zhang, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-375281/v1
Sztanek, F., Jakab, Á. A., Jebelovszki, É., Gaszner, B., Páll, D., Kempler, P., & Harangi, M. (2019) · Diabetologia Hungarica · doi:10.24121/dh.2019.16
Saasita, P. K., Kaddumukasa, M., Najjuma, J. N., Mbalinda, S. N., Kaddumukasa, M. N., Lekuya, H. M., Nakibuuka, J., Burant, C. J., Moore, S. M., Blixen, C. E., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2351298/v1
Razali, N. A. A., Shibraumalisi, N. A., Ismail, Z., Kadir, S. H. S. A., Abdul-Razak, S., Shariff, R. E. R., & Rahman, T. H. A. (2023) · IIUM Medical Journal Malaysia · doi:10.31436/imjm.v22i3.2297
Taylor, P. (2013) · Otago University Research Archive (University of Otago)
Jin, J.-L., Zhang, H.-W., Yexuan, C., Liu, H.-H., Hua, Q., Li, Y.-F., Zhang, Y., Wu, N.-Q., Zhu, C.-G., Xu, R., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12082779
Roy, A., Banerje, A. K., Mukherjee, S., Mondal, K. K., & Biswas, U. K. (2025) · Journal of Applied Biochemistry & Laboratory Medicine · doi:10.5005/jablm-11031-0016
Koba, S., Yokota, Y., Satoh, N., Ito, Y., Tsunoda, F., Sakai, K., Nakamura, Y., Shoji, M., Hirano, T., & Shinke, T. (2026) · Circulation Journal · doi:10.1253/circj.cj-25-0805
Self-citation
- Authors
- Koba, S., Yokota, Y., Hirano, T., Ito, Y., Ban, Y., Tsunoda, F., Sato, T., Shoji, M., Suzuki, H., Geshi, E., Kobayashi, Y., & Katagiri, T.
- Affiliations
- SHOWA Medical University (JP)
- Denka Seiken Co., Ltd. (Japan) (JP)
- Venue
- Journal of Atherosclerosis and Thrombosis
- Publisher
- Japan Atherosclerosis Society
- Published
- 2008
- Volume
- 15
- Issue
- 5
- Pages
- 250-260
- ISSN
- 1340-3478 (ISSN-L)
- 1880-3873
- OpenAlex
- W2053912643
- Cited by
- 102
- References
- 35
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 7 · 2020: 8 · 2019: 6 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 12 · 2012: 8
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Atherosclerosis and Thrombosis (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- small dense LDL, LDL particle size, LDL cholesterol, coronary artery disease, atherogenic lipoproteins, gradient gel electrophoresis, stable coronary artery disease, cardiovascular risk markers
- MeSH terms
- Adult, Aged, Coronary Artery Disease, Coronary Disease, Female, Humans, Cholesterol, LDL, Male, Middle Aged, Particle Size, Biomarkers, Case-Control Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review