Cited by 102Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsCholesterol and Lipid Metabolism

Small LDL-Cholesterol is Superior to LDL-Cholesterol for Determining Severe Coronary Atherosclerosis

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Koba, Shinji, Yokota, Yuuya, Hirano, Tsutomu, Ito, Yasuki, Ban, Yoshihisa, Tsunoda, Fumiyoshi, Sato, Takatoshi, Shoji, Makoto +4 more·2008·Journal of Atherosclerosis and Thrombosis

Abstract

AIM: Recent evidence suggests that small dense low-density lipoprotein (sd-LDL) particles are more atherogenic than large-LDL in spite of their lower cholesterol content. This study aimed to determine whether sd-LDL-cholesterol (sd-LDL-C) is superior to LDL-C as a biomarker of coronary heart disease (CHD). METHODS: LDL particle size determined by gradient gel electrophoresis and sd-LDL-C concentrations quantified by heparin-magnesium precipitation were compared between 482 stable CHD patients and 389 non-diabetic subjects without CHD who were not receiving any lipid-lowering drugs. RESULTS: Both male and female CHD patients had significantly smaller LDL particles and lower large-LDL-C concentrations (estimated by subtracting the sd-LDL-C concentration from the LDL-C concentration), and significantly higher sd-LDL-C concentrations than the control subjects. LDL-C concentrations were modestly higher and sd-LDL-C concentrations were significantly higher in 258 patients with angiographically documented severe CHD than in the patients with mild CHD irrespective of treatment by LDL-lowering drugs and history of myocardial infarction and/or coronary revascularization. Large-LDL-C concentrations, in contrast, were similar between the two groups. Multivariate logistic regression analysis revealed that sd-LDL-C levels were significantly associated with severe CHD independently of LDL-C. CONCLUSION: sd-LDL-C levels are more powerful than LDL-C levels for the determination of severe stable CHD.

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Research works printed but not linked: 2

  1. Saito Y: The Japan Atherosclerosis Society Guidelines for Diagnosis and Treatment of Atherosclerotic Cardiovascu- lar Disease 2002 (Editorial). J Atheroscler Thromb, 2004; 11:101-103
  2. Nichols AV, Krauss RM, and Musliner TA: Nondenatur- ing polyacrylamide gradient gel electrophoresis. Methods Enzymol, 1986; 128:417-431

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Authors
Koba, S., Yokota, Y., Hirano, T., Ito, Y., Ban, Y., Tsunoda, F., Sato, T., Shoji, M., Suzuki, H., Geshi, E., Kobayashi, Y., & Katagiri, T.
Affiliations
  • SHOWA Medical University (JP)
  • Denka Seiken Co., Ltd. (Japan) (JP)
Venue
Journal of Atherosclerosis and Thrombosis
Published
2008
Volume
15
Issue
5
Pages
250-260
ISSN
  • 1340-3478 (ISSN-L)
  • 1880-3873
OpenAlex
W2053912643
Cited by
102
References
35
Citations by year
2026: 4 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 7 · 2020: 8 · 2019: 6 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 12 · 2012: 8
FWCI
5.97
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • Journal of Atherosclerosis and Thrombosis (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords
small dense LDL, LDL particle size, LDL cholesterol, coronary artery disease, atherogenic lipoproteins, gradient gel electrophoresis, stable coronary artery disease, cardiovascular risk markers
MeSH terms
Adult, Aged, Coronary Artery Disease, Coronary Disease, Female, Humans, Cholesterol, LDL, Male, Middle Aged, Particle Size, Biomarkers, Case-Control Studies

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