Significance of small dense low-density lipoprotein-cholesterol concentrations in relation to the severity of coronary heart diseases

Koba, Shinji; Hirano, Tsutomu; Ito, Yasuki; Tsunoda, Fumiyoshi; Yokota, Yuuya; Ban, Yoshihisa; Iso, Yoshitaka; Suzuki, Hiroshi; Katagiri, Takashi

doi:10.1016/j.atherosclerosis.2005.12.002

Cited by 121Lipoproteins and Cardiovascular HealthCholesterol and Lipid MetabolismDiabetes, Cardiovascular Risks, and Lipoproteins

Significance of small dense low-density lipoprotein-cholesterol concentrations in relation to the severity of coronary heart diseases

Koba, Shinji, Hirano, Tsutomu, Ito, Yasuki, Tsunoda, Fumiyoshi, Yokota, Yuuya, Ban, Yoshihisa, Iso, Yoshitaka, Suzuki, Hiroshi +1 more·2006·Atherosclerosis

DOI 10.1016/j.atherosclerosis.2005.12.002

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Abstract

We have investigated the clinical significance of small dense low-density lipoprotein-cholesterol (sd-LDL-C) concentrations in coronary heart disease (CHD). We measured the LDL size by gradient gel electrophoresis and quantified sd-LDL-C concentrations by a newly developed rapid assay using heparin-magnesium precipitation in 225 consecutive CHD patients without any lipid-lowering medication and 142 healthy middle-aged subjects as controls. The LDL size was markedly smaller and sd-LDL-C levels were significantly higher in CHD patients than in controls of both sexes, whereas LDL-C levels were comparable between CHD and controls. The LDL-C levels were significantly higher in a subpopulation of 84 patients with acute coronary syndrome than in other patients groups, while LDL size and high-density lipoprotein-cholesterol (HDL-C) were not found to vary among the patients. The sd-LDL-C increased as the number of diseased vessels or Gensini atherosclerosis score increased. Among the 123 stable CHD patients, multiple logistic regression analysis revealed that sd-LDL-C levels were significantly associated with the clinically severe cases requiring coronary revascularization independently of LDL-C, HDL-C and apolipoprotein B. The sd-LDL mass plays a more important role in the progression of CHD than the LDL size, and the sd-LDL-C concentration serves as a powerful surrogate marker for the prevention of CHD.

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“A high small dense LDL level is a risk factor for ASCVD. (Evidence level: E-1a)”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [255]

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Authors: Koba, S., Hirano, T., Ito, Y., Tsunoda, F., Yokota, Y., Ban, Y., Iso, Y., Suzuki, H., & Katagiri, T.
Affiliations: SHOWA Medical University (JP)
Denka Seiken Co., Ltd. (Japan) (JP)
ORCID: Koba, Shinji
Hirano, Tsutomu
Ito, Yasuki
Iso, Yoshitaka
Suzuki, Hiroshi
Venue: Atherosclerosis
Publisher: Elsevier BV
Published: 2006-11
Volume: 189
Issue: 1
Pages: 206-214
ISSN: 0021-9150 (ISSN-L)
DOI: 10.1016/j.atherosclerosis.2005.12.002
OpenAlex: W1991602452
Cited by: 121
References: 30
Citations by year: 2026: 1 · 2025: 3 · 2024: 3 · 2023: 8 · 2022: 7 · 2021: 3 · 2020: 8 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 5 · 2015: 7 · 2014: 7 · 2013: 8 · 2012: 10
FWCI: 7.12
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Atherosclerosis (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: small dense LDL, coronary artery disease, LDL particle size, acute coronary syndrome, coronary revascularization, disease severity, cardiovascular risk markers
MeSH terms: Adult, Aged, Apolipoproteins B, Coronary Artery Disease, Electrophoresis, Polyacrylamide Gel, Female, Follow-Up Studies, Humans, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Prognosis, Retrospective Studies, Severity of Illness Index, Biomarkers, Coronary Angiography

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Significance of small dense low-density lipoprotein-cholesterol concentrations in relation to the severity of coronary heart diseases

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