The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
Are Short Chain Fatty Acids in Gut Microbiota Defensive Players for Inflammation and Atherosclerosis?
Open accessAbstract
Intestinal flora (microbiota) have recently attracted attention among lipid and carbohydrate metabolism researchers. Microbiota metabolize resistant starches and dietary fibers through fermentation and decomposition, and provide short chain fatty acids (SCFAs) to the host. The major SCFAs acetates, propionate and butyrate, have different production ratios and physiological activities. Several receptors for SCFAs have been identified as the G-protein coupled receptor 41/free fatty acid receptor 3 (GPR41/FFAR3), GPR43/FFAR2, GPR109A, and olfactory receptor 78, which are present in intestinal epithelial cells, immune cells, and adipocytes, despite their expression levels differing between tissues and cell types. Many studies have indicated that SCFAs exhibit a wide range of functions from immune regulation to metabolism in a variety of tissues and organs, and therefore have both a direct and indirect influence on our bodies. This review will focus on SCFAs, especially butyrate, and their effects on various inflammatory mechanisms including atherosclerosis. In the future, SCFAs may provide new insights into understanding the pathophysiology of chronic inflammation, metabolic disorders, and atherosclerosis, and we can expect the development of novel therapeutic strategies for these diseases.
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Cites
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Gut Microbiota and Obesity: A Role for Probiotics
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Metadata
- Authors
- Ohira, H., Tsutsui, W., & Fujioka, Y.
- Venue
- Journal of Atherosclerosis and Thrombosis
- Publisher
- Japan Atherosclerosis Society
- Published
- 2017
- Volume
- 24
- Issue
- 7
- Pages
- 660-672
- ISSN
- 1340-3478 (ISSN-L)
- 1880-3873
- OpenAlex
- W2617608982
- Cited by
- 482
- References
- 109
- FWCI
- 14.85
- Type
- journal article
- Language
- en
- Open access
- diamond
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- Ohira, H., Tsutsui, W., & Fujioka, Y. (2017). Are Short Chain Fatty Acids in Gut Microbiota Defensive Players for Inflammation and Atherosclerosis? Journal of Atherosclerosis and Thrombosis. https://doi.org/10.5551/jat.rv17006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
