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Cited by 835

The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.

Role of Oxidative Stress in Parkinson's Disease

Open access
Hwang, Onyou·2013·Experimental Neurobiology
DOI 10.5607/en.2013.22.1.11
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Abstract

Parkinson's disease (PD) is a progressive neurodegenerative movement disorder associated with a selective loss of the dopamine(DA)rgic neurons in the substantia nigra pars compacta and the degeneration of projecting nerve fibers in the striatum. Because there is currently no therapy that delays the neurodegenerative process, modification of the disease course by neuroprotective therapy is an important unmet clinical need. Toward this end, understanding cellular mechanisms that render the nigral neurons particularly vulnerable have been a subject of intensive research. Increasing evidence suggests that oxidative stress plays a major role. The metabolism of DA itself contributes to oxidative stress, resulting in modification of intracellular macromolecules whose functions are important for cell survival. Mitochondrial dysfunction and the consequent increase in reactive oxygen species also trigger a sequence of events that leads to cell demise. In addition, activated microglia produce nitric oxide and superoxide during neuroinflammatory responses, and this is aggravated by the molecules released by damaged DAergic neurons such as α-synuclein, neuromelanin and matrix metalloproteinase-3. Ways to reduce oxidative stress therefore can provide a therapeutic strategy. NAD(P)H:quinone reductase (NQO1) and other antioxidant enzymes, whose gene expression are commonly under the regulation of the transcription factor Nrf2, can serve as target proteins utilized toward development of disease-modifying therapy for PD.

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Metadata

Authors
Hwang, O.
Venue
Experimental Neurobiology
Publisher
The Korean Society for Brain and Neural Science
Published
2013-03-30
Volume
22
Issue
1
Pages
11-17
ISSN
  • 1226-2560 (ISSN-L)
  • 2093-8144
DOI
10.5607/en.2013.22.1.11
OpenAlex
W2142219833
Cited by
835
References
70
FWCI
26.41
Type
journal article
Language
en
Open access
bronze

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