The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Eveningness and Insomnia: Independent Risk Factors of Nonremission in Major Depressive Disorder
Open accessAbstract
BACKGROUND: It is unclear whether there is an association between chronotype and nonremission of depression, and whether the association is related to the confounding effect of insomnia. METHOD: A cohort of patients with major depressive disorder were assessed for chronotype (by Morningness-Eveningness Questinnaire [MEQ]), depressive symptoms, insomnia severity and clinical outcomes in a naturalistic follow-up study. RESULTS: Of the 253 recruited subjects (age 50.8 ± 10.2 y; female: 82.6%; response rate 90.0%), 19.4%, 56.1% and 24.5% patients were classified as eveningness, intermediate, and morningness, respectively. Evening-type subjects had higher insomnia severity, more severe depressive symptoms, and higher suicidality. Eveningness was associated with nonremission of depression with an odds ratio (OR) of 3.36 (95% confidence interval [CI] 1.35-8.34, P < 0.01), independent of insomnia severity. In addition, insomnia was an independent significant factor in contributing to nonremission of depression (OR = 1.12; 95% CI 1.05-1.19, P < 0.001). CONCLUSION: The independent association of eveningness with nonremission of depression suggested a significant underpinning of circadian involvement in major depressive disorder. Our findings support the need for a comprehensive assessment of sleep and circadian disturbances as well as integration of sleep and chronotherapeutic intervention in the management of depression.
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Cited by
Twenge, J. M., Cooper, A. B., Joiner, T. E., Duffy, M. E., & Binau, S. G. (2019) · Journal of Abnormal Psychology · doi:10.1037/abn0000410 · Cited by 1,469
Brain mechanisms of insomnia: new perspectives on causes and consequences
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Chronotype and circadian rhythm in bipolar disorder: A systematic review
Melo, M. C. A., Abreu, R. L. C., Linhares Neto, V. B., de Bruin, P. F. C., & de Bruin, V. M. S. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.06.007 · Cited by 324
The relationship between chronotype and depressive symptoms: a meta-analysis
Au, J., & Reece, J. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.04.021 · Cited by 297
Chronotype and psychiatric disorders
Kivelä, L., Papadopoulos, M. R., & Antypa, N. (2018) · Current Sleep Medicine Reports · doi:10.1007/s40675-018-0113-8 · Cited by 273
Metadata
- Authors
- Chan, J. W. Y., Lam, S. P., Li, S. X., Yu, M. W. M., Chan, N. Y., Zhang, J., & Wing, Y.-K.
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-05-01
- Volume
- 37
- Issue
- 5
- Pages
- 911-917
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- OpenAlex
- W2136160961
- Cited by
- 217
- References
- 16
- FWCI
- 21.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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