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Cited by 135Hormonal and reproductive studiesHypothalamic control of reproductive hormonesAdrenal Hormones and Disorders

Endocrine Society of Australia position statement on male hypogonadism (part 1): assessment and indications for testosterone therapy

Yeap, Bu B, Grossmann, Mathis, McLachlan, Robert I, Handelsman, David J, Wittert, Gary A, Conway, Ann J, Stuckey, Bronwyn GA, Lording, Douglas W +3 more·2016·Medical Journal of Australia
DOI 10.5694/mja16.00393
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Abstract

Introduction This article, Part 1 of the Endocrine Society of Australia's position statement on male hypogonadism, focuses on assessment of male hypogonadism, including the indications for testosterone therapy. (Part 2 will deal with treatment and therapeutic considerations.) Main recommendations Key points and recommendations are:Pathological hypogonadism arises due to diseases of the hypothalamus or pituitary gland (hypogonadotropic hypogonadism) or testes (hypergonadotropic hypogonadism). It is a clinical diagnosis with a pathological basis, confirmed by hormone assays.Hormonal assessment is based on measurement of circulating testosterone, luteinising hormone (LH) and follicle-stimulating hormone (FSH) concentrations. Measurement of sex hormone-binding globulin levels can be informative, but use of calculated free testosterone is not recommended for clinical decision making.Testosterone replacement therapy is warranted in men with pathological hypogonadism, regardless of age.Currently, there are limited data from high-quality randomised controlled trials with clinically meaningful outcomes to justify testosterone treatment in older men, usually with chronic disease, who have low circulating testosterone levels but without hypothalamic, pituitary or testicular disease.Obesity, metabolic syndrome and type 2 diabetes are associated with lowering of circulating testosterone level, but without elevation of LH and FSH levels. Whether these are non-specific consequences of non-r…

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Authors
Yeap, B. B., Grossmann, M., McLachlan, R. I., Handelsman, D. J., Wittert, G. A., Conway, A. J., Stuckey, B. G., Lording, D. W., Allan, C. A., Zajac, J. D., & Burger, H. G.
Affiliations
  • The University of Western Australia (AU)
  • The University of Melbourne (AU)
  • Hudson Institute of Medical Research (AU)
  • The University of Sydney (AU)
  • Royal Adelaide Hospital (AU)
  • Cabrini Hospital (AU)
Corresponding author
Yeap, Bu B
ORCID
Venue
Medical Journal of Australia
Publisher
Wiley
Published
2016-08
Volume
205
Issue
4
Pages
173-178
ISSN
  • 0025-729X (ISSN-L)
  • 1326-5377
DOI
10.5694/mja16.00393
OpenAlex
W2481968947
Cited by
135
References
18
Citations by year
2026: 9 · 2025: 14 · 2024: 16 · 2023: 15 · 2022: 13 · 2021: 13 · 2020: 11 · 2019: 12 · 2018: 18 · 2017: 9 · 2016: 4
FWCI
14.39
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The Medical Journal of Australia (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
male hypogonadism, testosterone replacement therapy, hypogonadotropic hypogonadism, hypergonadotropic hypogonadism, luteinizing hormone, follicle-stimulating hormone, sex hormone-binding globulin, free testosterone, obesity, metabolic syndrome, type 2 diabetes, older men
MeSH terms
Adult, Aged, Endocrinology, Humans, Hypogonadism, Male, Middle Aged, Societies, Medical, Testosterone, Hormone Replacement Therapy

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