Longitudinal changes in testosterone over five years in community-dwelling men

Shi, Zumin; Araujo, Andre B.; Martin, Sean; O'Loughlin, Peter; Wittert, Gary A.

doi:10.1210/jc.2012-3842

Cited by 165Hormonal and reproductive studiesHypothalamic control of reproductive hormonesSperm and Testicular Function

Longitudinal changes in testosterone over five years in community-dwelling men

Shi, Zumin, Araujo, Andre B., Martin, Sean, O'Loughlin, Peter, Wittert, Gary A.·2013·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2012-3842

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Abstract

CONTEXT: There are few population-based studies reporting longitudinal changes in total T, LH, FSH, and SHBG levels, and there is limited information on risk factors for their change. OBJECTIVE: The objective of the study was to examine 5-year changes in serum T, LH, FSH, and SHBG levels among Australian men. DESIGN: The study initially included a randomly selected, community-based cohort of 1588 men age 35 years or older at recruitment (mean age, 54 ± 11 y) with available data at 2 visits. Men on medications known to affect, or with established pathology of, the hypothalamo-pituitary gonadal axis were excluded, leaving 1382 for analysis. RESULTS: Mean baseline and follow-up T levels were 16.2 ± 1.4 and 15.6 ± 1.4 nmol/L, a change of -0.13 nmol/L/y. Annualized T changes were associated with obesity, being unmarried, and smoking at baseline, but not with diabetes, hypertension, or cardiovascular disease. T declined in men who had persistent depression or developed chronic disease, and it increased in men who were married, as compared to unmarried, at both time points. In the multivariate analysis, smoking cessation, development of central obesity (waist ≥ 100 cm), or generalized obesity (body mass index ≥ 30 kg/m(2)) resulted in T decreases of 0.36, 0.25, and 0.20 nmol/L/y, respectively. Quitting smoking, developing obesity, and having persisting depression were inversely related to SHBG change. CONCLUSIONS: An age-related decline in T levels is not inevitable but is largely explained by smoking behavior and intercurrent changes in health status, particularly obesity and depression.

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Testosterone levels exhibit time-, sleep-, and age-dependent circadian variations.
“T levels exhibit time, sleep, and age-dependent circadian variations.”
From Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials (2016) · cites this paper as [42]
Despite similar daily patterns, elderly males had significant blunting of peak versus trough testosterone levels, with differences of 61-205 ng/dl compared with 141-354 ng/dl in younger men.
“Despite similar patterns of variation throughout the day, elderly males experienced significant blunting of peak versus trough levels, with differences in high and low values of 61–205 ng/dl (2.1–7.1 nmol/L) compared to 141–354 ng/dl (4.9–12.3 nmol/L) in younger men.”
From Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials (2016) · cites this paper as [42]
Early studies comparing young men aged 25-27 with elderly men aged 71 found peak testosterone concentrations from 3-8 AM, extended to 2 PM in elderly men, and trough levels from early afternoon to late evening.
“Early studies comparing young (mean age 25–27 years) versus elderly males (mean age 71 years) demonstrated peak T concentrations in the 3–8 AM time period (extended to 2 PM in elderly males), with trough levels noted in the early afternoon to late evening.”
From Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials (2016) · cites this paper as [42]
SHBG, free testosterone, and bioavailable testosterone also show similar circadian variations, with SHBG peaking in the afternoon.
“SHBG, fT, and bioavailable T also exhibit similar circadian variations, with SHBG peaking in the afternoon hours.”
From Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials (2016) · cites this paper as [42]

The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267 · see citing works
Overweight, Obesity, and Depression: A Systematic Review and Meta-analysis of Longitudinal Studies
Luppino, F. S., de Wit, L. M., Bouvy, P. F., Stijnen, T., Cuijpers, P., Penninx, B. W. J. H., & Zitman, F. G. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.2 · Cited by 4,322 · see citing works
Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
Harman, S. M., Metter, E. J., Tobin, J. D., Pearson, J., & Blackman, M. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7219 · Cited by 2,760 · see citing works
Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts Male Aging Study
Feldman, H. A., Longcope, C., Derby, C. A., Johannes, C. B., Araujo, A. B., Coviello, A. D., Bremner, W. J., & McKinlay, J. B. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.2.8201 · Cited by 1,861 · see citing works
Screening Depressed Patients in Family Practice
Beck, A. T., & Beck, R. W. (1972) · Postgraduate Medicine · doi:10.1080/00325481.1972.11713319 · Cited by 1,836 · see citing works
Agreement between self-report questionnaires and medical record data was substantial for diabetes, hypertension, myocardial infarction and stroke but not for heart failure
Okura, Y., Urban, L. H., Mahoney, D. W., Jacobsen, S. J., & Rodeheffer, R. J. (2004) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2004.04.005 · Cited by 1,237 · see citing works
Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study
Wu, F. C. W., Tajar, A., Pye, S. R., Silman, A. J., Finn, J. D., O'Neill, T. W., Bartfai, G., Casanueva, F., Forti, G., Giwercman, A., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1972 · Cited by 939 · see citing works
Endogenous Testosterone and Mortality in Men: A Systematic Review and Meta-Analysis
Araujo, A. B., Dixon, J. M., Suarez, E. A., Murad, M. H., Guey, L. T., & Wittert, G. A. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1137 · Cited by 671 · see citing works
Self-citation
Validation of self-reported chronic conditions and health services in a managed care population11The full text of this article is available at http://www.elsevier.com/locate/ajpmonline.
Martin, L. M., Leff, M., Calonge, N., Garrett, C., & Nelson, D. E. (2000) · American Journal of Preventive Medicine · doi:10.1016/s0749-3797(99)00158-0 · Cited by 584 · see citing works
Marital Status and Health
Verbrugge, L. M. (1979) · Journal of Marriage and the Family · doi:10.2307/351696 · Cited by 486 · see citing works
Relationship Between Testosterone Levels, Insulin Sensitivity, and Mitochondrial Function in Men
Pitteloud, N., Mootha, V. K., Dwyer, A. A., Hardin, M., Lee, H., Eriksson, K.-F., Tripathy, D., Yialamas, M., Groop, L., Elahi, D., et al. (2005) · Diabetes Care · doi:10.2337/diacare.28.7.1636 · Cited by 472 · see citing works
Low testosterone levels are common and associated with insulin resistance in men with diabetes
Grossmann, M., Thomas, M. C., Panagiotopoulos, S., Sharpe, K., MacIsaac, R. J., Clarke, S., Zajac, J. D., & Jerums, G. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2177 · Cited by 468 · see citing works
Testosterone treatment and mortality in men with low testosterone levels
Shores, M. M., Smith, N. L., Forsberg, C. W., Anawalt, B. D., & Matsumoto, A. M. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2591 · Cited by 460 · see citing works
Atkins and other low-carbohydrate diets: hoax or an effective tool for weight loss?
Astrup, A. V., Larsen, T. M., & Harper, A. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16986-9 · Cited by 422 · see citing works
The Relative Contributions of Aging, Health, and Lifestyle Factors to Serum Testosterone Decline in Men
Travison, T. G., Araujo, A. B., Kupelian, V., O’Donnell, A. B., & McKinlay, J. B. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1859 · Cited by 410 · see citing works
Validity of self-reported diagnoses leading to hospitalization: a comparison of self-reports with hospital records in a prospective study of American adults.
Bergmann, M., Byers, T., Freedman, D. S., & Mokdad, A. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009387 · Cited by 372 · see citing works
Longitudinal Relation between Endogenous Testosterone and Cardiovascular Disease Risk Factors in Middle-aged Men: A 13-Year Follow-up of Former Multiple Risk Factor Intervention Trial Participants
Zmuda, J. M., Cauley, J. A., Kriska, A. M., Glynn, N. W., Gutai, J. P., & Kuller, L. H. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009326 · Cited by 362 · see citing works
A Population-Level Decline in Serum Testosterone Levels in American Men
Travison, T. G., de Araújo, A. B., O’Donnell, A. B., Kupelian, V. A., & McKinlay, J. B. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1375 · Cited by 335 · see citing works
Androgens and Diabetes in Men
Selvin, E., Feinleib, M., Zhang, L., Rohrmann, S., Rifai, N., Nelson, W. G., Dobs, A., Basaria, S., Golden, S. H., & Platz, E. A. (2007) · Diabetes Care · doi:10.2337/dc06-1579 · Cited by 333 · see citing works
Association of Testosterone and Estradiol Deficiency with Osteoporosis and Rapid Bone Loss in Older Men
Fink, H. A., Ewing, S. K., Ensrud, K. E., Barrett-Connor, E., Taylor, B. C., Cauley, J. A., & Orwoll, E. S. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0173 · Cited by 319 · see citing works
Body mass index, waist circumference and waist to hip ratio and change in sex steroid hormones: the Massachusetts Male Ageing Study
Derby, C. A., Zilber, S., Brambilla, D., Morales, K. H., & McKinlay, J. B. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02560.x · Cited by 315 · see citing works
Overweight, Obesity, and Depression A Systematic Review and Meta-analysis of Longitudinal Studies
Luppino, F. S., Wit, L. M. D., Bouvy, P. F., Stijnen, T., Cuijpers, P. J., Penninx, B. W. J. H., & Zitman, F. G. (2010) · Leiden Repository (Leiden University) · Cited by 287 · see citing works
The associations of age, lifestyle factors and chronic disease with testosterone in men: The Tromso Study
Svartberg, J., Midtby, M., Bonaa, K., Sundsfjord, J., Joakimsen, R., & Jorde, R. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1490145 · Cited by 257 · see citing works
Development and validation of a sensitive liquid chromatography–tandem mass spectrometry assay to simultaneously measure androgens and estrogens in serum without derivatization
Harwood, D. T., & Handelsman, D. J. (2009) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.09.003 · Cited by 243 · see citing works
Validity and Reliability of Self-reported Diabetes in the Atherosclerosis Risk in Communities Study
Schneider, A. L. C., Pankow, J. S., HEISS, G. M., & Selvin, E. (2012) · American Journal of Epidemiology · doi:10.1093/aje/kws156 · Cited by 239 · see citing works
Testosterone, Gonadotropin, and Cortisol Secretion in Male Patients With Major Depression
Schweiger, U., Deuschle, M., Weber, B., Körner, A., Lammers, C., Schmider, J., Gotthardt, U., & Heuser, I. (1999) · Psychosomatic Medicine · doi:10.1097/00006842-199905000-00007 · Cited by 222 · see citing works
Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self-reporting very good health: The healthy man study
Sartorius, G., Spasevska, S., Idan, A., Turner, L., Forbes, E., Zamojska, A., Allan, C. A., Ly, L. P., Conway, A. J., McLachlan, R. I., et al. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04432.x · Cited by 209 · see citing works
Endocrinology of the aging male
de Araújo, A. B., & Wittert, G. (2011) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.11.004 · Cited by 180 · see citing works
Self-citation
Secular Decline in Male Testosterone and Sex Hormone Binding Globulin Serum Levels in Danish Population Surveys
Andersson, A., Jensen, T. K., Juul, A., Petersen, J. H., Jørgensen, T., & Skakkebæk, N. E. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2633 · Cited by 174 · see citing works
Low Free Testosterone Concentration as a Potentially Treatable Cause of Depressive Symptoms in Older Men
Almeida, O. P., Yeap, B. B., Hankey, G. J., Jamrozik, K., & Flicker, L. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.33 · Cited by 158 · see citing works
Effects of body size and hypertension treatments on cardiovascular event rates: subanalysis of the ACCOMPLISH randomised controlled trial
Weber, M. A., Jamerson, K., Bakris, G. L., Weir, M. R., Zappe, D., Zhang, Y., Dahlof, B., Velazquez, E. J., & Pitt, B. (2013) · The Lancet · doi:10.1016/s0140-6736(12)61343-9 · Cited by 150 · see citing works
The North West Adelaide Health Study: detailed methods and baseline segmentation of a cohort for selected chronic diseases
Grant, J. F., Chittleborough, C., Taylor, A. W., Grande, E. D., WILSON, D. H., Phillips, P. J. J., Adams, R., Cheek, J., Price, K., Gill, T. K., et al. (2006) · Epidemiologic Perspectives & Innovations · doi:10.1186/1742-5573-3-4 · Cited by 144 · see citing works
Age-Related Changes in Serum Testosterone and Sex Hormone Binding Globulin in Australian Men: Longitudinal Analyses of Two Geographically Separate Regional Cohorts
Liu, P. Y., Beilin, J., Meier, C., Nguyen, T. V., Center, J. R., Leedman, P. J., Seibel, M. J., Eisman, J. A., & Handelsman, D. J. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0862 · Cited by 142 · see citing works
Alcohol's effects on male reproduction.
Emanuele, M. A., & Emanuele, N. V. (1998) · Europe PMC (PubMed Central) · Cited by 138 · see citing works
Serum androgen levels in black, Hispanic, and white men
Litman, H. J., Bhasin, S., Link, C. L., Araujo, A. B., & McKinlay, J. B. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0037 · Cited by 127 · see citing works
CIGARETTE SMOKING AND INCREASED ENDOGENOUS ESTROGEN LEVELS IN MEN
BARRETT-CONNOR, E., & KHAW, K.-T. (1987) · American Journal of Epidemiology · doi:10.1093/aje/126.2.187 · Cited by 121 · see citing works
Evidence for geographical and racial variation in serum sex steroid levels in older men
Orwoll, E. S., Nielson, C. M., Labrie, F., Barrett-Connor, E., Cauley, J. A., Cummings, S. R., Ensrud, K., Karlsson, M., Lau, E., Leung, P. C., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2435 · Cited by 100 · see citing works
Testosterone and cardiovascular disease in men
Morris, P., & Channer, K. S. (2012) · Asian Journal of Andrology · doi:10.1038/aja.2012.21 · Cited by 86 · see citing works
Neuroendocrine aspects of primary endogenous depression VIII. Pituitary-gonadal axis activity in male patients and matched control subjects
Rubín, R. T., Poland, R. E., & Lesser, I. M. (1989) · Psychoneuroendocrinology · doi:10.1016/0306-4530(89)90020-6 · Cited by 85 · see citing works
Sexual activity and plasma testosterone levels in hypertensive males
Fogari, R. (2002) · American Journal of Hypertension · doi:10.1016/s0895-7061(01)02280-4 · Cited by 76 · see citing works
The relationship between serum levels of insulin and sex hormone-binding globulin in men: the effect of weight loss
Strain, G., Zumoff, B., Rosner, W., & Pi-Sunyer, X. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.4.7962291 · Cited by 69 · see citing works
Aromatase Inhibitors in Cigarette Smoke, Tobacco Leaves and Other Plants
Osawa, Y., Tochigi, B., Tochigi, M., Ohnishi, S., WATANABE, Y., Bullion, K. A., Osawa, G., Nakabayashi, Y., & Yarborough, C. (1990) · Journal of enzyme inhibition · doi:10.3109/14756369009040741 · Cited by 59 · see citing works
[Prevalence of hypertension among Chinese adults in 2010].
Yichong, L., Wang, L., Jiang, Y., Li, X., Zhang, M., & Hu, N. (2012) · PubMed · Cited by 54 · see citing works
Diltiazem prevention of toxic effects of monosodium glutamate on ovaries in rats.
Bojanić, V., Bojanić, Z., Najman, S. J., Savić, T., Jakovljevic, V. L., Najman, S., & Jančić, S. (2009) · PubMed · Cited by 49 · see citing works
Gonadotropin release after administration of GnRH in depressed patients and healthy volunteers
Amsterdam, J. D., Winokur, A., Caroff, S. N., & Snyder, P. J. (1981) · Journal of Affective Disorders · doi:10.1016/0165-0327(81)90005-7 · Cited by 39 · see citing works
Relationship Between Testosterone Levels, Insulin Sensitivity, and Mitochondrial Function in Men
Hayes, F. J. (2006) · Diabetes Care · doi:10.2337/diacare.29.03.06.dc05-2326 · Cited by 22 · see citing works
Clinical correlates of sex steroids and gonadotropins in men over the late adulthood: the Framingham Heart Study
Haring, R., Xanthakis, V., Coviello, A., Sullivan, L., Bhasin, S., Wallaschofski, H., Murabito, J. M., & Vasan, R. S. (2012) · International Journal of Andrology · doi:10.1111/j.1365-2605.2012.01285.x · Cited by 22 · see citing works
Low Testosterone Levels are Common and Associated with Insulin Resistance in Men with Diabetes
Meikle, W. A. (2008) · Yearbook of Endocrinology · doi:10.1016/s0084-3741(08)79227-8 · Cited by 22 · see citing works
The Relative Contributions of Aging, Health, and Lifestyle Factors to Serum Testosterone Decline in Men
Meikle, A. W. (2008) · Yearbook of Endocrinology · doi:10.1016/s0084-3741(08)79194-7 · Cited by 20 · see citing works
Total testosterone may not decline with ageing in K orean men aged 40 years or older
Kim, Y., Hong, D., Lee, D., Joo, N., & Kim, K. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04375.x · Cited by 16 · see citing works
Body mass index, waist circumference and waist to hip ratio and change in sex steroid hormones: the Massachusetts Male Ageing Study
Meikle, A. W. (2007) · Yearbook of Endocrinology · doi:10.1016/s0084-3741(08)70213-0 · Cited by 11 · see citing works
Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men
Roizen, M. F. (2009) · Yearbook of Anesthesiology and Pain Management · doi:10.1016/s1073-5437(09)79183-1 · Cited by 4 · see citing works
Testosterone and Cardiovascular Disease in Men
de Sá, E. Q. C. (2013) · Journal of Steroids & Hormonal Science · doi:10.4172/2157-7536.1000142 · Cited by 3 · see citing works

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Luo, S., Yeung, S. L. A., Zhao, J. V., Burgess, S., & Schooling, C. M. (2019) · BMJ · doi:10.1136/bmj.l476 · Cited by 128 · see citing works
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Yeap, B. B., Grossmann, M., McLachlan, R. I., Handelsman, D. J., Wittert, G. A., Conway, A. J., Stuckey, B. G., Lording, D. W., Allan, C. A., Zajac, J. D., et al. (2016) · Medical Journal of Australia · doi:10.5694/mja16.00393 · Cited by 135 · see citing works
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Cappola, A. R., Auchus, R. J., Fuleihan, G. E., Handelsman, D. J., Kalyani, R. R., McClung, M. R., Stuenkel, C. A., Thorner, M. O., & Verbalis, J. G. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad225 · Cited by 102 · see citing works
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Edelstein, R. S., Wardecker, B. M., Chopik, W. J., Moors, A. C., Shipman, E. L., & Lin, N. J. (2014) · American Journal of Human Biology · doi:10.1002/ajhb.22670 · Cited by 79 · see citing works
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Self-citation
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Morgan, D., & Tsai, S. C. (2015) · Critical Care Clinics · doi:10.1016/j.ccc.2015.03.004 · Cited by 69 · see citing works
Genetic predictors of testosterone and their associations with cardiovascular disease and risk factors: A Mendelian randomization investigation
Schooling, C. M., Luo, S., Yeung, S. L. A., Thompson, D. J., Karthikeyan, S., Bolton, T. R., Mason, A. M., Ingelsson, E., & Burgess, S. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.05.051 · Cited by 68 · see citing works
Serum Testosterone is Inversely and Sex Hormone-binding Globulin is Directly Associated with All-cause Mortality in Men
Yeap, B. B., Marriott, R. J., Antonio, L., Chan, Y. X., Raj, S., Dwivedi, G., Reid, C. M., Anawalt, B. D., Bhasin, S., Dobs, A. S., et al. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa743 · Cited by 67 · see citing works
Self-citation
Lower serum testosterone concentrations are associated with a higher incidence of dementia in men: The UK Biobank prospective cohort study
Marriott, R. J., Murray, K., Flicker, L. A., Hankey, G. J., Matsumoto, A. M., Dwivedi, G., Antonio, L., Almeida, O. P., Bhasin, S., Dobs, A. S., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12529 · Cited by 67 · see citing works
Self-citation
The relationship between sleep disorders and testosterone
Wittert, G. (2014) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0000000000000069 · Cited by 66 · see citing works
Self-citation
Associations of Serum Testosterone and Sex Hormone–Binding Globulin With Incident Cardiovascular Events in Middle-Aged to Older Men
Yeap, B. B., Marriott, R. J., Antonio, L., Raj, S., Dwivedi, G., Reid, C. M., Anawalt, B. D., Bhasin, S., Dobs, A. S., Handelsman, D. J., et al. (2021) · Annals of Internal Medicine · doi:10.7326/m21-0551 · Cited by 62 · see citing works
Self-citation
The role of sex hormone-binding globulin (SHBG), testosterone, and other sex steroids, on the development of type 2 diabetes in a cohort of community-dwelling middle-aged to elderly men
Gyawali, P., Martin, S., Heilbronn, L. K., Vincent, A. D., Taylor, A. W., Adams, R., O’Loughlin, P. D., & Wittert, G. (2018) · Acta Diabetologica · doi:10.1007/s00592-018-1163-6 · Cited by 56 · see citing works
Self-citation
Aging and androgens: Physiology and clinical implications
Anawalt, B. D., & Matsumoto, A. M. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09765-2 · Cited by 55 · see citing works
Current topics in testosterone replacement of hypogonadal men
Nieschlag, E. (2014) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2014.09.008 · Cited by 55 · see citing works
Transdermal testosterone replacement therapy in men
Koch, C. A., Ullah, M. I., & Riche, D. M. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s43475 · Cited by 54 · see citing works
Adverse health effects of testosterone deficiency (TD) in men
Traish, A. M. (2014) · Steroids · doi:10.1016/j.steroids.2014.05.010 · Cited by 51 · see citing works
Low Testosterone in Adolescents & Young Adults
Cohen, J. A., Nassau, D. E., Patel, P., & Ramasamy, R. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00916 · Cited by 55 · see citing works
Testosterone, cognitive decline and dementia in ageing men
Yeap, B. B., & Flicker, L. A. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09728-7 · Cited by 51 · see citing works
Sleep and the Endocrine System
Morgan, D., & Tsai, S. C. (2016) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2015.10.002 · Cited by 52 · see citing works
Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men
Watts, E. L., Appleby, P. N., Albanes, D., Black, A., Chan, J. M., Chen, C., Cirillo, P. M., Cohn, B. A., Cook, M. B., Donovan, J., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187741 · Cited by 46 · see citing works
Factors Associated With Circulating Sex Hormones in Men
Marriott, R. J., Murray, K., Adams, R., Antonio, L., Ballantyne, C. M., Bauer, D. C., Bhasin, S., Biggs, M. L., Cawthon, P. M., Couper, D. J., et al. (2023) · Annals of Internal Medicine · doi:10.7326/m23-0342 · Cited by 46 · see citing works
Self-citation
Hormonal changes and their impact on cognition and mental health of ageing men
Yeap, B. B. (2014) · Maturitas · doi:10.1016/j.maturitas.2014.05.015 · Cited by 48 · see citing works
Progressive impairment of testicular endocrine function in ageing men: Testosterone and dihydrotestosterone decrease, and luteinizing hormone increases, in men transitioning from the 8th to 9th decades of life
Yeap, B. B., Manning, L. A., Chubb, S. A. P., Handelsman, D. J., Almeida, O. P., Hankey, G. J., & Flicker, L. A. (2017) · Clinical Endocrinology · doi:10.1111/cen.13484 · Cited by 45 · see citing works
Testosterone and cardiovascular disease risk
Yeap, B. B. (2015) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000161 · Cited by 44 · see citing works
Testosterone treatment in older men: clinical implications and unresolved questions from the Testosterone Trials
Yeap, B. B., Page, S. T., & Grossmann, M. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30416-3 · Cited by 43 · see citing works
Clinical practice update on testosterone therapy for male hypogonadism: Contrasting perspectives to optimize care
Yeap, B. B., & Wu, F. C. W. (2018) · Clinical Endocrinology · doi:10.1111/cen.13888 · Cited by 44 · see citing works
Higher Serum Sex Hormone–Binding Globulin Levels Are Associated With Incident Cardiovascular Disease in Men
Gyawali, P., Martin, S., Heilbronn, L. K., Vincent, A. D., Jenkins, A. J., Januszewski, A. S., Adams, R., O’Loughlin, P. D., & Wittert, G. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-01317 · Cited by 38 · see citing works
Self-citation
Testosterone replacement attenuates cognitive decline in testosterone-deprived lean rats, but not in obese rats, by mitigating brain oxidative stress
Pintana, H., Pongkan, W., Pratchayasakul, W., Chattipakorn, N., & Chattipakorn, S. C. (2015) · AGE · doi:10.1007/s11357-015-9827-4 · Cited by 39 · see citing works
Testosterone therapy to prevent type 2 diabetes mellitus in at‐risk men (T4DM): Design and implementation of a double‐blind randomized controlled trial
Wittert, G., Atlantis, E. E., Allan, C. A., Bracken, K., Conway, A. J., Daniel, M., Gebski, V., Grossmann, M., Hague, W. E., Handelsman, D. J., et al. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13601 · Cited by 37 · see citing works
Self-citation
Sociodemographic, lifestyle and medical influences on serum testosterone and sex hormone–binding globulin in men from UK Biobank
Yeap, B. B., Marriott, R. J., Antonio, L., Bhasin, S., Dobs, A. S., Dwivedi, G., Flicker, L. A., Matsumoto, A. M., Ohlsson, C., ORWOLL, E. S., et al. (2020) · Clinical Endocrinology · doi:10.1111/cen.14342 · Cited by 35 · see citing works
Self-citation
Longitudinal change instead of baseline testosterone predicts depressive symptoms
Kische, H., Pieper, L., Venz, J., Klotsche, J., März, W., Koch, U., Pittrow, D. B., Lehnert, H., Silber, S., Stalla, G. K., et al. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.12.013 · Cited by 34 · see citing works
Testosterone deprivation intensifies cognitive decline in obese male rats via glial hyperactivity, increased oxidative stress, and apoptosis in both hippocampus and cortex
Chunchai, T., Apaijai, N., Keawtep, P., Mantor, D., Arinno, A., Pratchayasakul, W., Chattipakorn, N., & Chattipakorn, S. C. (2018) · Acta Physiologica · doi:10.1111/apha.13229 · Cited by 34 · see citing works
Testosterone deficiency, insulin-resistant obesity and cognitive function
Pintana, H., Chattipakorn, N., & Chattipakorn, S. C. (2015) · Metabolic Brain Disease · doi:10.1007/s11011-015-9655-3 · Cited by 33 · see citing works
Age-related changes in estradiol and longitudinal associations with fat mass in men
Wu, A., Shi, Z., Martin, S., Vincent, A. D., Heilbronn, L. K., & Wittert, G. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201912 · Cited by 33 · see citing works
Self-citation
Newly Diagnosed Erectile Dysfunction and Risk of Depression: A Population-Based 5-year Follow-Up Study in Taiwan
Chou, P., Chou, W., Chen, M., Lai, C., Wen, Y., Yeh, K.-C., Chang, W.-P., & Chou, Y. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12792 · Cited by 33 · see citing works
Decrease in semen quality and Leydig cell function in infertile men: a longitudinal study
Olesen, I. A., Joensen, U. N., Petersen, J. H., Almstrup, K., Meyts, E. R., Carlsen, E., McLachlan, R. I., Juul, A., & Jørgensen, N. (2018) · Human Reproduction · doi:10.1093/humrep/dey283 · Cited by 33 · see citing works
Association between testosterone levels and mood disorders: A minireview
Zito, S., Nosari, G., Pigoni, A., Moltrasio, C., & Delvecchio, G. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.02.108 · Cited by 32 · see citing works
Trends in Testosterone Prescription and Public Health Concerns
Gabrielsen, J. S., Najari, B. B., Alukal, J. P., & Eisenberg, M. L. (2016) · Urologic Clinics of North America · doi:10.1016/j.ucl.2016.01.010 · Cited by 31 · see citing works
Early Decline of Androgen Levels in Healthy Adult Men: An Effect of Aging Per Se? A Prospective Cohort Study
Banica, T., Verroken, C., Reyns, T., Mahmoud, A., T’Sjoen, G., Fiers, T., Kaufman, J.-M., & Lapauw, B. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa915 · Cited by 32 · see citing works
Androgens Modulate Endothelial Function and Endothelial Progenitor Cells in Erectile Physiology
Traish, A. M., & Galoosian, A. (2013) · Korean journal of urology · doi:10.4111/kju.2013.54.11.721 · Cited by 30 · see citing works
Dynamic alteration of serum testosterone with aging: a cross-sectional study from Shanghai, China
Liu, Z., Liu, J., Shi, X., Wang, L., Yang, Y., & Tao, M. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0107-z · Cited by 29 · see citing works
Reference Ranges and Association of Age and Lifestyle Characteristics with Testosterone, Sex Hormone Binding Globulin, and Luteinizing Hormone among 1166 Western Chinese Men
Shen, X., Wang, R., Yu, N. H., Shi, Y., Li, H., Xiong, C., Li, Y., Wells, E. M., & Zhou, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164116 · Cited by 27 · see citing works
Could androgens be relevant to partly explain why men have lower life expectancy than women?
Schooling, C. M. (2015) · Journal of Epidemiology & Community Health · doi:10.1136/jech-2015-206336 · Cited by 27 · see citing works
Age-Related Male Hypogonadism and Cognitive Impairment in the Elderly: Focus on the Effects of Testosterone Replacement Therapy on Cognition
Lisco, G., Giagulli, V. A., Tullio, A. D., Pergola, G. D., Guastamacchia, E., & Triggiani, V. (2020) · Geriatrics · doi:10.3390/geriatrics5040076 · Cited by 27 · see citing works
Androgen deficiency and type 2 diabetes mellitus
Gibb, F. W., & Strachan, M. W. J. (2014) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2014.04.004 · Cited by 29 · see citing works
Tachykinin neurokinin 3 receptor antagonists: a new treatment for cardiovascular disease?
Schooling, C. M. (2017) · The Lancet · doi:10.1016/s0140-6736(16)31648-8 · Cited by 24 · see citing works
Comparing the Impacts of Testosterone and Exercise on Lean Body Mass, Strength and Aerobic Fitness in Aging Men
GREEN, D. J., Chasland, L. C., Yeap, B. B., & Naylor, L. H. (2024) · Sports Medicine - Open · doi:10.1186/s40798-024-00703-x · Cited by 26 · see citing works
Is Rising Obesity Causing a Secular (Age-Independent) Decline in Testosterone among American Men?
Mazur, A., Westerman, R., & Mueller, U. O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076178 · Cited by 23 · see citing works
Testosterone and depressive symptoms among men in the Diabetes Prevention Program
Kim, C., Barrett-Connor, E. L., Aroda, V. R., Mather, K. J., Christophi, C. A., Horton, E. S., Pi-Sunyer, X., Bray, G. A., Labrie, F., & Golden, S. H. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.06.009 · Cited by 24 · see citing works
Testosterone deprivation has neither additive nor synergistic effects with obesity on the cognitive impairment in orchiectomized and/or obese male rats
Pintana, H., Pratchayasakul, W., Sa‐nguanmoo, P., Pongkan, W., Tawinvisan, R., Chattipakorn, N., & Chattipakorn, S. C. (2015) · Metabolism · doi:10.1016/j.metabol.2015.10.015 · Cited by 22 · see citing works
Testosterone, frailty and physical function in older men
Hsu, B., Cumming, R. G., & Handelsman, D. J. (2018) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2018.1475227 · Cited by 22 · see citing works
Testosterone and the risk of incident atrial fibrillation in older men: further analysis of the ASPREE study
Tran, C., Yeap, B. B., Ball, J., Clayton‐Chubb, D., Hussain, S. M., Brodtmann, A. G., Tonkin, A. M., Neumann, F., Schneider, H. G., Fitzgerald, S. M., et al. (2024) · EClinicalMedicine · doi:10.1016/j.eclinm.2024.102611 · Cited by 22 · see citing works
The longitudinal association between inflammation and incident depressive symptoms in men: The effects of hs-CRP are independent of abdominal obesity and metabolic disturbances
Tully, P. J., Baumeister, H., Bengel, J., Jenkins, A. J., Januszewski, A. S., Martin, S., & Wittert, G. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.11.058 · Cited by 20 · see citing works
Self-citation
Testosterone, Diabetes Risk, and Diabetes Prevention in Men
Yeap, B. B., & Wittert, G. (2022) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2021.11.004 · Cited by 19 · see citing works
Self-citation
Testosterone and its metabolites: differential associations with cardiovascular and cerebrovascular events in men
Yeap, B. B. (2018) · Asian Journal of Andrology · doi:10.4103/aja.aja_50_17 · Cited by 19 · see citing works
Aging and Reproduction
Gore, A. C., Hall, J. E., & Hayes, F. J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00037-5 · Cited by 19 · see citing works
Longitudinal changes in serum testosterone and sex hormone‐binding globulin in men aged 40–69 years from the UK Biobank
Marriott, R. J., Murray, K., Hankey, G. J., Manning, L. A., Dwivedi, G., Wu, F. C. W., & Yeap, B. B. (2021) · Clinical Endocrinology · doi:10.1111/cen.14648 · Cited by 18 · see citing works
Testosterone therapy in older men: clinical implications of recent landmark trials
Grossmann, M., Anawalt, B. D., & Yeap, B. B. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae071 · Cited by 18 · see citing works
Genetically predicted testosterone and electrocardiographic QT interval duration in Chinese: a Mendelian randomization analysis in the Guangzhou Biobank Cohort Study
Zhao, J. V., Jiang, C., Lam, T., Liu, B., Cheng, K. K., Xu, L., Long, M. J., Zhang, W., Leung, G. M., & Schooling, C. M. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyu241 · Cited by 18 · see citing works
Elucidating the Biological Mechanisms Linking Depressive Symptoms With Type 2 Diabetes in Men
Tully, P. J., Baumeister, H., Martin, S., Atlantis, E. E., Jenkins, A. J., Januszewski, A. S., O’Loughlin, P. D., Taylor, A. W., & Wittert, G. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000263 · Cited by 17 · see citing works
Self-citation
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Trumble, B. C., Pontzer, H., Stieglitz, J., Cummings, D. K., Wood, B. M., Thompson, M. E., Raichlen, D. A., Beheim, B., Yetish, G. M., Kaplan, H. S., et al. (2023) · American Journal of Human Biology · doi:10.1002/ajhb.23949 · Cited by 18 · see citing works
Endogenous sex hormone levels and coronary heart disease risk in postmenopausal women: A meta-analysis of prospective studies
Wang, H., Li, Y., Wang, X., Bu, J., Yan, G., & Lou, D. (2017) · European Journal of Preventive Cardiology · doi:10.1177/2047487317693133 · Cited by 17 · see citing works
Endogenous testosterone and mortality risk
Meyer, E. J., & Wittert, G. (2018) · Asian Journal of Andrology · doi:10.4103/aja.aja_70_17 · Cited by 17 · see citing works
Self-citation
Obstructive sleep apnea is not an independent determinant of testosterone in men
Clarke, B. M., Vincent, A. D., Martin, S., Adams, R., Appleton, S., Vakulin, A., Jesudason, D. R., & Wittert, G. (2020) · European Journal of Endocrinology · doi:10.1530/eje-19-0978 · Cited by 17 · see citing works
Self-citation
Association of Genetically Predicted Serum Estradiol With Risk of Thromboembolism in Men: A Mendelian Randomization Study
Nethander, M., Quester, J., Vandenput, L., & Ohlsson, C. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab164 · Cited by 16 · see citing works
Effects of androgens on glucose metabolism
Umapathysivam, M. M., Grossmann, M., & Wittert, G. (2022) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2022.101654 · Cited by 18 · see citing works
Self-citation
Association of lipid accumulation products with testosterone deficiency in adult American men: A cross‐sectional study
Liu, Q., Huang, Y., Wang, M., Jiang, H., & Zhang, X. (2022) · Andrology · doi:10.1111/andr.13355 · Cited by 16 · see citing works
Dipeptidyl peptidase 4 inhibitor improves brain insulin sensitivity, but fails to prevent cognitive impairment in orchiectomy obese rats
Pintana, H., Pongkan, W., Pratchayasakul, W., Chattipakorn, N., & Chattipakorn, S. C. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0099 · Cited by 16 · see citing works
Associations between urinary polycyclic aromatic hydrocarbon metabolites and serum testosterone in U.S. adult males: National Health and nutrition examination survey 2011–2012
Wang, L., Hu, W., Xia, Y., & Wang, X. (2017) · Environmental Science and Pollution Research · doi:10.1007/s11356-017-8407-9 · Cited by 15 · see citing works
Testosterone and cardiovascular disease
Schooling, C. M. (2014) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000065 · Cited by 14 · see citing works
Hormones and Cardiovascular Disease in Older Men
Yeap, B. B., & Flicker, L. A. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.12.004 · Cited by 14 · see citing works
Aging and sex hormones in males
Decaroli, M. C., Vincentis, S. D., & Rochira, V. (2021) · Vitamins and hormones · doi:10.1016/bs.vh.2020.12.014 · Cited by 14 · see citing works
The Illusory Case for Treatment of an Invented Disease
Handelsman, D. J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.682620 · Cited by 12 · see citing works
Immunoregulatory effects of testosterone supplementation combined with exercise training in men with Inclusion Body Myositis: a double‐blind, placebo‐controlled, cross‐over trial
Coudert, J. D., Slater, N., Sooda, A., Beer, K., Lim, E. M., Boyder, C., Zhang, R., Mastaglia, F. L., Learmonth, Y. C., Fairchild, T. J., et al. (2022) · Clinical & Translational Immunology · doi:10.1002/cti2.1416 · Cited by 12 · see citing works
Androgens In Men Study (AIMS): protocol for meta-analyses of individual participant data investigating associations of androgens with health outcomes in men
Yeap, B. B., Marriott, R. J., Adams, R., Antonio, L., Ballantyne, C. M., Bhasin, S., Cawthon, P. M., Couper, D. J., Dobs, A. S., Flicker, L. A., et al. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-034777 · Cited by 12 · see citing works
Self-citation
Diet and exercise interventions reduce serum asprosin and the corresponding hypothalamic– pituitary–gonad-axis dysfunction in obese men
Yao, T., Song, C., Yu, Y.-J., Cheng, Y., Lu, H.-Y., Li, J., Yang, Y., Tang, D.-H., & Yi, X. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.896735 · Cited by 11 · see citing works
Decreased testosterone secretion index and free testosterone level with multiple symptoms for late-onset hypogonadism identification: a nationwide multicenter study with 5980 aging males in China
Li, H., Gu, Y., Shang, X., Zhou, Y., Zhang, H., Zuo, L., Mei, G., Xia, W., Guan, H.-T., Xiang, W., et al. (2020) · Aging · doi:10.18632/aging.202227 · Cited by 11 · see citing works
Late-Onset Hypogonadism as Primary Testicular Failure
Swee, D. S., & Gan, E. H. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00372 · Cited by 11 · see citing works
Testosterone Therapy in Older Men: Present and Future Considerations
Yeap, B. B., Tran, C., Douglass, C. M., & McNeil, J. J. (2025) · Drugs & Aging · doi:10.1007/s40266-025-01209-1 · Cited by 10 · see citing works
Testosterone and type 2 diabetes prevention: translational lessons from the T4DM study
Wittert, G., Grossmann, M., Yeap, B. B., & Handelsman, D. J. (2023) · Journal of Endocrinology · doi:10.1530/joe-22-0223 · Cited by 10 · see citing works
Self-citation
The Impact of Testosterone on Alzheimer's Disease Are Mediated by Lipid Metabolism and Obesity: A Mendelian Randomization Study
Zhang, L., Yang, F., Ma, J., Hu, Y., Li, M., Wang, C., Chang, X., & Yang, L. (2023) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2023.116 · Cited by 9 · see citing works
Potential Intervention Targets in Utero and Early Life for Prevention of Hormone Related Cancers
Schooling, C. M., Houghton, L. C., & Terry, M. B. (2016) · PEDIATRICS · doi:10.1542/peds.2015-4268e · Cited by 9 · see citing works
Hormones, Age, and Erectile Dysfunction: Should Routine Testing Be Part of the Initial Evaluation?
Porav-Hodade, D., Gherasim, R. D., Kosovski, I.-B., Voidazan, T. S., Crişan, N., Petruţ, B., Galiș, R., Feciche, B. O., Ilona, M. O. K., & Todea-Moga, C. (2025) · Diagnostics · doi:10.3390/diagnostics15030294 · Cited by 9 · see citing works
Enzyme immunoassay may be inadequate for measuring salivary testosterone in older men
Mazur, A., & Clifton, S. (2018) · The Aging Male · doi:10.1080/13685538.2018.1509206 · Cited by 9 · see citing works
Genetically Predicted Testosterone and Systemic Inflammation in Men: A Separate-Sample Mendelian Randomization Analysis in Older Chinese Men
Zhao, J. V., Jiang, C., Lam, T. H., Liu, B., Cheng, K. K., Xu, L., Yeung, S. L. A., Zhang, W., Leung, G. M., & Schooling, C. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126442 · Cited by 8 · see citing works
Late-Onset Hypogonadism
Rastrelli, G., & Forti, G. (2017) · Endocrinology · doi:10.1007/978-3-319-29456-8_31-1 · Cited by 8 · see citing works

Longitudinal Changes in Sex Hormones in a Population of Older Community-dwelling Men
Hills, S. T., Mansfield, T. A., Bhasin, S., & ORWOLL, E. S. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf652
CLINCAL STUDY The associations of age, lifestyle factors and chronic disease with testosterone in men: the Tromsø Study
Svartberg, J., Midtby, M., Bønaa, K. H., Sundsfjord, J., Joakimsen, R. M., & Jorde, R. (2015)
The associations of age, lifestyle factors and chronic disease with testosterone in men: The Tromso Study
Svartberg, J., Midtby, M., Bonaa, K., Sundsfjord, J., Joakimsen, R., & Jorde, R. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1490145 · Cited by 257 · see citing works
SAT-163 Characterization of Sex Hormone Changes in a Cohort of Older Community Dwelling Men
Hills, S. T., Mansfield, T. A., & ORWOLL, E. S. (2025) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaf149.2013
Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study
Wu, F. C. W., Tajar, A., Pye, S. R., Silman, A. J., Finn, J. D., O'Neill, T. W., Bartfai, G., Casanueva, F., Forti, G., Giwercman, A., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1972 · Cited by 939 · see citing works

Authors: Shi, Z., Araujo, A. B., Martin, S., O'Loughlin, P., & Wittert, G. A.
Affiliations: The University of Adelaide (AU)
Corresponding author: Shi, Zumin
ORCID: Shi, Zumin
Martin, Sean
Wittert, Gary A.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2013-08
Volume: 98
Issue: 8
Pages: 3289-3297
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2012-3842
OpenAlex: W2137939611
Cited by: 165
References: 53
Citations by year: 2026: 3 · 2025: 8 · 2024: 15 · 2023: 13 · 2022: 19 · 2021: 6 · 2020: 13 · 2019: 10 · 2018: 15 · 2017: 12 · 2016: 17 · 2015: 14 · 2014: 18 · 2013: 2
FWCI: 13.32
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Funders: Eli Lilly and Company
Medical Research Council
National Health and Medical Research Council (627227)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords: testosterone, longitudinal change, community-dwelling men, luteinizing hormone, follicle-stimulating hormone, sex hormone-binding globulin, hypothalamic-pituitary-gonadal axis, obesity, smoking, smoking cessation, depression, marital status, aging
MeSH terms: Adult, Aged, Aging, Blood Glucose, Depression, Glycated Hemoglobin, Humans, Life Style, Longitudinal Studies, Male, Middle Aged, Obesity, Sex Hormone-Binding Globulin, Testosterone, Smoking Cessation

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Longitudinal changes in testosterone over five years in community-dwelling men

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