The natural history of symptomatic androgen deficiency in men: onset, progression, and spontaneous remission

Travison, Thomas G.; Shackelton, Rebecca; Araujo, Andre B.; Hall, Susan A.; Williams, Rachel E.; Clark, Richard V.; O'Donnell, Amy B.; McKinlay, John B.

doi:10.1111/j.1532-5415.2008.01679.x

Cited by 89Hormonal and reproductive studiesMenopause: Health Impacts and TreatmentsAdrenal Hormones and Disorders

The natural history of symptomatic androgen deficiency in men: onset, progression, and spontaneous remission

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Travison, Thomas G., Shackelton, Rebecca, Araujo, Andre B., Hall, Susan A., Williams, Rachel E., Clark, Richard V., O'Donnell, Amy B., McKinlay, John B.·2008·Journal of the American Geriatrics Society

DOI 10.1111/j.1532-5415.2008.01679.xPMC PMC5556701

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Abstract

OBJECTIVES: To describe the onset, progression, and remission of symptomatic androgen deficiency (SAD) using longitudinal data from the Massachusetts Male Aging Study (MMAS). DESIGN: A prospective, population-based study of men living in Boston, Massachusetts. Data were collected in three waves: T1 (1987/89), T2 (1995/97), T3 (2002/04). Onset, progression, and remission were defined in terms of transitions in SAD status from one wave to the next. SETTING: In-person, in-home interviews. PARTICIPANTS: Seven hundred sixty-six community-dwelling men aged 40 to 70 at baseline (T1) contributed data from T1 to T2 and 391 from T2 to T3. MEASUREMENTS: SAD was defined in terms of serum total and free testosterone (T) levels and symptoms associated with low circulating androgens. Total T and sex hormone-binding globulin (SHBG) were measured using radioimmunoassay. Free T was calculated from total T and SHBG measurements. RESULTS: At T2 or T3, the likelihood of SAD was markedly greater for subjects who had exhibited SAD at the previous wave (odds ratio=3.8, 95% confidence interval=1.9-7.4), overall 55% of subjects who exhibited SAD experienced remission by the next study wave. The probability of SAD was greater with older age and greater body mass index. Multivariate models demonstrated that the likelihood of remission was at least 50% for most subpopulations. CONCLUSION: Over approximately 15 years of follow-up, SAD did not represent a stable health state. The likelihood of SAD would remit exceeded the likelihood that it would not, particularly among younger and leaner men.

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HPT axis suppression in men with functional hypogonadism is potentially reversible.
“Third, the HPT axis suppression in men with functional hypogonadism is potentially reversible.”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [13]
In a 15-year longitudinal study of US men with symptomatic androgen deficiency, >50% remitted either because symptoms resolved or testosterone normalized.
“In a 15-year longitudinal study of US men with symptomatic androgen deficiency, >50% remitted either because symptoms resolved or testosterone normalized (13).”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [13]

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The natural history of symptomatic androgen deficiency in men: longitudinal results from the Massachusetts Male Aging Study
Travison, T. G. (2010) · 12th European Congress of Endocrinology
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The prevalence of and risk factors for androgen deficiency in aging Taiwanese men
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Self-citation
Changes in Total, Free, Bioavailable, and Calculated Free Testosterone Concentrations in Aging Males and the Frequency of Clinical Symptoms of Androgen Deficiency Syndrome* Zmiany stężeń testosteronu całkowitego, wolnego, biodostępnego i wolnego kalkulowanego z wiekiem a występowanie klinicznych objawów zespołu niedoboru androgenów
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Deficiencia androgénica en hombres de 60 años y más del área de salud Vedado Androgen deficiency in men aged 60 or more from Vedado health area
Seijas, E. Á., Peña, G. M., Alzugaray, M. G., Calzado, C. M. A., Álvarez, A. Á., & Leyva, S. S. (2009) · DOAJ (DOAJ: Directory of Open Access Journals)

Authors: Travison, T. G., Shackelton, R., Araujo, A. B., Hall, S. A., Williams, R. E., Clark, R. V., O'Donnell, A. B., & McKinlay, J. B.
Affiliations: New England Research Institutes (US)
Corresponding author: Travison, Thomas G.
ORCID: Travison, Thomas G.
Hall, Susan A.
Williams, Rachel E.
Clark, Richard V.
Venue: Journal of the American Geriatrics Society
Publisher: Wiley
Published: 2008-05
Volume: 56
Issue: 5
Pages: 831-839
ISSN: 0002-8614 (ISSN-L)
1532-5415
DOI: 10.1111/j.1532-5415.2008.01679.x
PMC: PMC5556701
OpenAlex: W1534951686
Cited by: 89
References: 52
Citations by year: 2025: 3 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 10 · 2016: 4 · 2015: 6 · 2014: 9 · 2013: 6 · 2012: 7
FWCI: 6.29
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of the American Geriatrics Society (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: New England Research Institutes
National Institutes of Health (7p01ag004673-05)
National Institute on Aging (AG 04673, T32AG023482)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 51345, R01DK044995, DK44995, R01DK051345)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: male hypogonadism, testosterone, sex hormone-binding globulin, spontaneous regression, disease onset, disease progression, body mass index, older men, Massachusetts Male Aging Study
MeSH terms: Adult, Aged, Androgens, Boston, Cross-Sectional Studies, Humans, Hypogonadism, Longitudinal Studies, Male, Middle Aged, Reference Values, Remission, Spontaneous, Testosterone, Likelihood Functions, Disease Progression, Andropause

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The natural history of symptomatic androgen deficiency in men: onset, progression, and spontaneous remission

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