The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Introns: The Functional Benefits of Introns in Genomes
Open accessAbstract
The intron has been a big biological mystery since it was first discovered in several aspects. First, all of the completely sequenced eukaryotes harbor introns in the genomic structure, whereas no prokaryotes identified so far carry introns. Second, the amount of total introns varies in different species. Third, the length and number of introns vary in different genes, even within the same species genome. Fourth, all introns are copied into RNAs by transcription and DNAs by replication processes, but intron sequences do not participate in protein-coding sequences. The existence of introns in the genome should be a burden to some cells, because cells have to consume a great deal of energy to copy and excise them exactly at the correct positions with the help of complicated spliceosomal machineries. The existence throughout the long evolutionary history is explained, only if selective advantages of carrying introns are assumed to be given to cells to overcome the negative effect of introns. In that regard, we summarize previous research about the functional roles or benefits of introns. Additionally, several other studies strongly suggesting that introns should not be junk will be introduced.
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An integrated encyclopedia of DNA elements in the human genome
The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072
Pan, Q., Shai, O., Lee, L. J., Frey, B. J., & Blencowe, B. J. (2008) · Nature Genetics · doi:10.1038/ng.259 · Cited by 3,951
The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
Welter, D., MacArthur, J., Morales, J., Burdett, T., Hall, P., Junkins, H., Klemm, A., Flicek, P., Manolio, T., Hindorff, L., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1229 · Cited by 2,707
The Spliceosome: Design Principles of a Dynamic RNP Machine
Wahl, M. C., Will, C. L., & Lührmann, R. (2009) · Cell · doi:10.1016/j.cell.2009.02.009 · Cited by 2,665
Gilbert, W. (1978) · Nature · doi:10.1038/271501a0 · Cited by 2,300
Fundamentals of molecular evolution
(1991) · Journal of Human Evolution · doi:10.1016/0047-2484(91)90069-8 · Cited by 1,654
BASKERVILLE, S., & BARTEL, D. P. (2005) · RNA · doi:10.1261/rna.7240905 · Cited by 1,508
The Origins of Genome Architecture
Abdel-Haleem, H. (2007) · Journal of Heredity · doi:10.1093/jhered/esm073 · Cited by 1,139
Lewis, B. P., Green, R. E., & Brenner, S. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0136770100 · Cited by 1,067
The origins of genome architecture
(2007) · Choice Reviews Online · doi:10.5860/choice.45-0862 · Cited by 953
Cited by
Kirungu, J. N., Magwanga, R. O., Lu, P., Cai, X., Zhou, Z., Wang, X., Peng, R., Wang, K., & Liu, F. (2019) · BMC Genetics · doi:10.1186/s12863-019-0756-6 · Cited by 76
Psychogenetic, genetic and epigenetic mechanisms in Candida auris: Role in drug resistance
Rabaan, A. A., Eljaaly, K., Alfouzan, W. A., Mutair, A. A., Alhumaid, S., Alfaraj, A. H., Aldawood, Y., Alsaleh, A. A., Albayat, H., Azmi, R. A., et al. (2023) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2022.12.012 · Cited by 14
Metadata
- Authors
- Jo, B.-S., & Choi, S. S.
- Venue
- Genomics & Informatics
- Publisher
- Korea Genome Organization
- Published
- 2015
- Volume
- 13
- Issue
- 4
- Pages
- 112
- ISSN
- 1598-866X (ISSN-L)
- 2234-0742
- OpenAlex
- W2264731258
- Cited by
- 359
- References
- 71
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- gold
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