Psychogenetic, genetic and epigenetic mechanisms in Candida auris: Role in drug resistance
Open accessAbstract
In recent years, we are facing the challenge of drug resistance emergence in fungi. The availability of limited antifungals and development of multi-drug resistance in fungal pathogens has become a serious concern in the past years in the health sector. Although several cellular, molecular, and genetic mechanisms have been proposed to explain the drug resistance mechanism in fungi, but a complete understanding of the molecular and genetic mechanisms is still lacking. Besides the genetic mechanism, epigenetic mechanisms are pivotal in the fungal lifecycle and disease biology. However, very little is understood about the role of epigenetic mechanisms in the emergence of multi-drug resistance in fungi, especially in Candida auris (C. auris). The current narrative review summaries the clinical characteristics, genomic organization, and molecular/genetic/epigenetic mechanisms underlying the emergence of drug resistance in C. auris. A very few studies have attempted to evaluate the role of epigenetic mechanisms in C. auris. Furthermore, advanced genetic tools such as the CRISP-Cas9 system can be utilized to elucidate the epigenetic mechanisms and their role in the emergence of multi-drug resistance in C. auris.
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Self-citation
Flagged first, then by citations
Research works printed but not linked: 3
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Cited by
Sorted by citations
e Silva, D. M., de Souza Lacerda, L., de Souza Andrioli, A., Braz, W. R., Campos, L. M., de Paiva, M. R. B., Pittella, F., Fabri, R. L., & Tavares, G. D. (2025) · Fundamental & Clinical Pharmacology · doi:10.1111/fcp.70046 · Cited by 7 · see citing works
“…most frequently isolated species, non-albicans species, including Candida glabrata , Candida parapsilosis , Candida tropicalis , Candida krusei , and the emerging multidrug-resistant Candida auris , are gaining clinical significance due to rising resistance to frontline antifungal classes [4, 5].”
- Authors
- Rabaan, A. A., Eljaaly, K., Alfouzan, W. A., Mutair, A. A., Alhumaid, S., Alfaraj, A. H., Aldawood, Y., Alsaleh, A. A., Albayat, H., Azmi, R. A., AlKaabi, N., Alzahrani, S. J., AlBahrani, S., Sulaiman, T., Alshukairi, A. N., Abuzaid, A. A., Garout, M., Ahmad, R., & Muhammad, J.
- Affiliations
- Alfaisal University (SA)
- University of Arizona (US)
- Farwaniya Hospital (KW)
- Ministry of Health (SA)
- Mohammed Almana College for Medical Sciences (SA)
- King Saud Medical City (SA)
- King Fahd Military Medical Complex (SA)
- King Fahd Medical City (SA)
- Security Forces Hospital (SA)
- Umm al-Qura University (SA)
- University of Haripur (PK)
- Corresponding author
- Rabaan, Ali A.
- Muhammad, Javed
- ORCID
- Venue
- Journal of Infection and Public Health
- Publisher
- Elsevier BV
- Published
- 2023-02
- Volume
- 16
- Issue
- 2
- Pages
- 257-263
- ISSN
- 1876-0341 (ISSN-L)
- OpenAlex
- W4313252825
- Cited by
- 14
- References
- 107
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 4
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Infection and Public Health (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Research Online (University of Wollongong) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Keywords
- Candida auris, antifungal resistance, multidrug resistance, epigenetic mechanisms, genetic mechanisms, fungal pathogens, CRISPR/Cas9, fungal genomics
- MeSH terms
- Candida auris, Antifungal Agents, Candida, Genetics, Behavioral, Humans, Microbial Sensitivity Tests, Drug Resistance, Fungal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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