Cited by 14Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Plant Pathogen Control

Psychogenetic, genetic and epigenetic mechanisms in Candida auris: Role in drug resistance

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Rabaan, Ali A., Eljaaly, Khalid, Alfouzan, Wadha A., Mutair, Abbas Al, Alhumaid, Saad, Alfaraj, Amal H., Aldawood, Yahya, Alsaleh, Abdulmonem A. +11 more·2023·Journal of Infection and Public Health

Abstract

In recent years, we are facing the challenge of drug resistance emergence in fungi. The availability of limited antifungals and development of multi-drug resistance in fungal pathogens has become a serious concern in the past years in the health sector. Although several cellular, molecular, and genetic mechanisms have been proposed to explain the drug resistance mechanism in fungi, but a complete understanding of the molecular and genetic mechanisms is still lacking. Besides the genetic mechanism, epigenetic mechanisms are pivotal in the fungal lifecycle and disease biology. However, very little is understood about the role of epigenetic mechanisms in the emergence of multi-drug resistance in fungi, especially in Candida auris (C. auris). The current narrative review summaries the clinical characteristics, genomic organization, and molecular/genetic/epigenetic mechanisms underlying the emergence of drug resistance in C. auris. A very few studies have attempted to evaluate the role of epigenetic mechanisms in C. auris. Furthermore, advanced genetic tools such as the CRISP-Cas9 system can be utilized to elucidate the epigenetic mechanisms and their role in the emergence of multi-drug resistance in C. auris.

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  1. Santos MA, Tuite MF. The CUG codon is decoded in vivo as serine and not leucine in Candida albicans. Nucleic Acids Res 1995;23(9):1481-6.
  2. Muñoz JF, Welsh RM, Shea T, Batra D, Gade L, Litvintseva AP, et al. Chromosomal rearrangements and loss of subtelomeric adhesins linked to clade-specific phenotypes in Candida auris. BioRxiv 2019:754143.
  3. Lee WG, Shin JH, Uh Y, Kang MG, Kim SH, Park KH, et al. First three reported cases of nosocomial fungemia caused by Candida auris. J Clin Microbiol 2011;49(9):3139-42. PubMed PMID: 21715586. Pubmed Central PMCID: Pmc3165631. Epub 2011/07/01. eng.

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Authors
Rabaan, A. A., Eljaaly, K., Alfouzan, W. A., Mutair, A. A., Alhumaid, S., Alfaraj, A. H., Aldawood, Y., Alsaleh, A. A., Albayat, H., Azmi, R. A., AlKaabi, N., Alzahrani, S. J., AlBahrani, S., Sulaiman, T., Alshukairi, A. N., Abuzaid, A. A., Garout, M., Ahmad, R., & Muhammad, J.
Affiliations
  • Alfaisal University (SA)
  • University of Arizona (US)
  • Farwaniya Hospital (KW)
  • Ministry of Health (SA)
  • Mohammed Almana College for Medical Sciences (SA)
  • King Saud Medical City (SA)
  • King Fahd Military Medical Complex (SA)
  • King Fahd Medical City (SA)
  • Security Forces Hospital (SA)
  • Umm al-Qura University (SA)
  • University of Haripur (PK)
Corresponding author
  • Rabaan, Ali A.
  • Muhammad, Javed
Venue
Journal of Infection and Public Health
Publisher
Elsevier BV
Published
2023-02
Volume
16
Issue
2
Pages
257-263
ISSN
1876-0341 (ISSN-L)
OpenAlex
W4313252825
Cited by
14
References
107
Citations by year
2026: 4 · 2025: 3 · 2024: 3 · 2023: 4
FWCI
0.38
Type
journal article
Language
en
Open access
Locations
  • Journal of Infection and Public Health (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Research Online (University of Wollongong) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
Keywords
Candida auris, antifungal resistance, multidrug resistance, epigenetic mechanisms, genetic mechanisms, fungal pathogens, CRISPR/Cas9, fungal genomics
MeSH terms
Candida auris, Antifungal Agents, Candida, Genetics, Behavioral, Humans, Microbial Sensitivity Tests, Drug Resistance, Fungal

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