The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Human Adult Dental Pulp Stem Cells Enhance Poststroke Functional Recovery Through Non-Neural Replacement Mechanisms
Open accessAbstract
Human adult dental pulp stem cells (DPSCs), derived from third molar teeth, are multipotent and have the capacity to differentiate into neurons under inductive conditions both in vitro and following transplantation into the avian embryo. In this study, we demonstrate that the intracerebral transplantation of human DPSCs 24 hours following focal cerebral ischemia in a rodent model resulted in significant improvement in forelimb sensorimotor function at 4 weeks post-treatment. At this time, 2.3 ± 0.7% of engrafted cells had survived in the poststroke brain and demonstrated targeted migration toward the stroke lesion. In the peri-infarct striatum, transplanted DPSCs differentiated into astrocytes in preference to neurons. Our data suggest that the dominant mechanism of action underlying DPSC treatment that resulted in enhanced functional recovery is unlikely to be due to neural replacement. Functional improvement is more likely to be mediated through DPSC-dependent paracrine effects. This study provides preclinical evidence for the future use of human DPSCs in cell therapy to improve outcome in stroke patients.
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Cites
Bederson, J. B., Pitts, L. H., Tsuji, M., Nishimura, M. C., Davis, R. L., & Bartkowski, H. (1986) · Stroke · doi:10.1161/01.str.17.3.472 · Cited by 2,681
Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic
Zhang, Z. G., & Chopp, M. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70061-4 · Cited by 596
Cell transplantation therapy for stroke
Bliss, T., Guzman, R., Daadi, M., & Steinberg, G. K. (2007) · Stroke · doi:10.1161/01.str.0000247888.25985.62 · Cited by 374
Bacigaluppi, M., Pluchino, S., Jametti, L. P., Kilic, E., Kilic, Ü., Salani, G., Brambilla, E., West, M. J., Comi, G., Martino, G., et al. (2009) · Brain · doi:10.1093/brain/awp174 · Cited by 350
Good Laboratory Practice: Preventing Introduction of Bias at the Bench
Macleod, M. R., Fisher, M., O'Collins, V., Sena, E. S., Dirnagl, U., Bath, P. M. W., Buchan, A., van der Worp, H. B., Traystman, R., Minematsu, K., et al. (2009) · Stroke · doi:10.1161/strokeaha.108.525386 · Cited by 331
Horie, N., Pereira, M. P., Niizuma, K., Sun, G., Keren-Gill, H., Encarnacion, A., Shamloo, M., Hamilton, S. A., Jiang, K., Huhn, S., et al. (2011) · Stem Cells · doi:10.1002/stem.584 · Cited by 240
Neurogenesis, angiogenesis, and MRI indices of functional recovery from stroke
Chopp, M., Zhang, Z. G., & Jiang, Q. (2007) · Stroke · doi:10.1161/01.str.0000250235.80253.e9 · Cited by 203
Cited by
Doeppner, T. R., Herz, J., Görgens, A., Schlechter, J., Ludwig, A.-K., Radtke, S., de Miroschedji, K., Horn, P. A., Giebel, B., & Hermann, D. M. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0078 · Cited by 772
Current advances in ischemic stroke research and therapies
Barthels, D., & Das, H. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.09.012 · Cited by 709
Tatullo, M., Marrelli, M., Shakesheff, K. M., & White, L. J. (2015) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1899 · Cited by 353
Dabrowska, S., Andrzejewska, A., Lukomska, B., & Janowski, M. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1571-8 · Cited by 298
Tsang, K. S., Ng, C. P. S., Zhu, X. L., Wong, G. K. C., Lu, G., Ahuja, A. T., Wong, K. S. L., Ng, H. K., & Poon, W. S. (2017) · World Journal of Stem Cells · doi:10.4252/wjsc.v9.i8.133 · Cited by 49
Metadata
- Authors
- Leong, W. K., Henshall, T. L., Arthur, A., Kremer, K. L., Lewis, M. D., Helps, S. C., Field, J., Hamilton-Bruce, M. A., Warming, S., Manavis, J., Vink, R., Gronthos, S., & Koblar, S. A.
- Venue
- Stem Cells Translational Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-02-22
- Volume
- 1
- Issue
- 3
- Pages
- 177-187
- ISSN
- 2157-6564 (ISSN-L)
- 2157-6580
- OpenAlex
- W2097556137
- Cited by
- 173
- References
- 7
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- gold
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- Leong, W. K., Henshall, T. L., Arthur, A., Kremer, K. L., Lewis, M. D., Helps, S. C., Field, J., Hamilton-Bruce, M. A., Warming, S., Manavis, J., Vink, R., Gronthos, S., & Koblar, S. A. (2012). Human Adult Dental Pulp Stem Cells Enhance Poststroke Functional Recovery Through Non-Neural Replacement Mechanisms. Stem Cells Translational Medicine. https://doi.org/10.5966/sctm.2011-0039
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
