Prevalence and long-term follow-up outcomes of testicular adrenal rest tumours in children and adolescent males with congenital adrenal hyperplasia
Abstract
Objective: There are a few studies regarding the prevalence of testicular adrenal rest tumours ( TART s) in boys and adolescent males with congenital adrenal hyperplasia ( CAH ), and there is little information regarding the treatment outcomes in patients with TART s. The aim of this study was to determine the long‐term treatment outcomes in boys and adolescent males with CAH . Patients and methods: Sixty boys and adolescent males with CAH , who were between 2 and 18 years of age, were included in the study. Fifty‐five patients had 21‐hydroxylase deficiency (21‐ OHD ), and five patients had 11‐β hydroxylase deficiency (11β‐ OHD ). All patients were screened for TART s by scrotal ultrasonography ( US ) performed by an experienced radiologist. Results: TART prevalence was 18·3% in 2–18 years’ of age; eight patients had 21‐ OHD , and three had 11β‐ OHD . The youngest patient with TART was 4 years old, whereas eight patients with RT s were at puberty. Only two patients had tight metabolic control: eight patients had stage 2, one had stage 4, and two had stage five rest tumours. In four patients with stage 2 TART s, tumours disappeared after high‐dose steroid treatment and did not recur. Shrinkage of tumour was observed in two patients. Testis‐sparing surgery was performed in one patient with stage five tumour. Gonadal functions were normal in patients with partially regressed tumours. Two patients became fathers of healthy male off‐springs. Conclusions: Detection and treatment for TART s in children with CAH at younger ages, earlier stages, may prevent infertility in adulthood. Therefore, we recommend that scrotal US screening should be performed in every 1–2 years starting from early childhood.
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TART has also been reported in 11βOH and HSD3B2 deficiency.
“and has also been reported in 11βOH and HSD3B2 deficiency, 117-119”
From Congenital adrenal hyperplasia (2017) · cites this paper as [118]
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- Authors
- Aycan, Z., Bas, V. N., Cetinkaya, S., Yilmaz Agladioglu, S., & Tiryaki, T.
- Affiliations
- Dr Sami Ulus Çocuk Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi (TR)
- Clinics of Pediatric Endocrinology Dr. Sami Ulus Research and Training Hospital of Women's and Children's Health and Diseases Ankara Turkey
- Clinics of Pediatric Surgery Ankara Children's Hematology and Oncology Research and Training Hospital Ankara Turkey
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2013-04-10
- Volume
- 78
- Issue
- 5
- Pages
- 667-672
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2073903800
- Cited by
- 98
- References
- 25
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3 · 2023: 6 · 2022: 22 · 2021: 7 · 2020: 2 · 2019: 8 · 2018: 9 · 2017: 7 · 2016: 6 · 2015: 9 · 2014: 8 · 2013: 2 · 2012: 1
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- AYBU AVESIS (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Surgery › Testicular diseases and treatments
- Keywords
- congenital adrenal hyperplasia, 21-hydroxylase deficiency, 11beta-hydroxylase deficiency, cancer prevalence, long-term treatment outcomes, high-dose steroid therapy, testis-sparing surgery, infertility prevention, gonadal function, children and adolescents
- MeSH terms
- Adolescent, Adrenal Hyperplasia, Congenital, Adrenal Rest Tumor, Child, Humans, Male
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