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Mir-223 regulates the number and function of myeloid-derived suppressor cells in multiple sclerosis and experimental autoimmune encephalomyelitis

Cantoni, Claudia, Cignarella, Francesca, Ghezzi, Laura, Mikesell, Bob, Bollman, Bryan, Berrien-Elliott, Melissa M., Ireland, Aaron R., Fehniger, Todd A. +2 more·2017·Acta Neuropathologica

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  • The top 10 enriched miRNAs in spinal microglia compared to all spinal neurons include miRNAs known to be associated with immune responses, such as miR-223-3p, and novel miRNAs not previously associated with microglial function.

    “Additionally, Fig. 4B highlights the top 10 enriched miRNAs in spinal microglia as compared to all spinal neurons. This analysis yields miRNAs known to be associated with immune responses, including miR-223-3p31, but also novel miRNAs that have not been previously associated with microglial function.”

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  1. [1]Ambros V 2004 The functions of animal microRNAs Nature 431 350 355 10.1038/nature02871 15372042 · DOI · Paper page
  2. [2]Bader AG Brown D Winkler M 2010 The promise of microRNA replacement therapy Cancer Res 70 7027 7030 10.1158/0008-5472.CAN-10-2010 20807816 PMC2940943 · DOI
  3. [3]Bettelli E Pagany M Weiner HL Linington C Sobel RA Kuchroo VK 2003 Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis J Exp Med 197 1073 1081 10.1084/jem.20021603 12732654 PMC2193967 · DOI
  4. [5]Condamine T Ramachandran I Youn JI Gabrilovich DI 2015 Regulation of tumor metastasis by myeloid-derived suppressor cells Annu Rev Med 66 97 110 10.1146/annurev-med-051013-052304 25341012 PMC4324727 · DOI
  5. [6]De Santis G Ferracin M Biondani A Caniatti L Rosaria Tola M Castellazzi M Zagatti B Battistini L Borsellino G Fainardi E 2010 Altered miRNA expression in T regulatory cells in course of multiple sclerosis J Neuroimmunol 226 165 171 10.1016/j.jneuroim.2010.06.009 20637509 · DOI
  6. [7]Fazi F Racanicchi S Zardo G Starnes LM Mancini M Travaglini L Diverio D Ammatuna E Cimino G Lo-Coco F 2007 Epigenetic silencing of the myelopoiesis regulator micro-RNA-223 by the AML1/ETO oncoprotein Cancer Cell 12 457 466 10.1016/j.ccr.2007.09.020 17996649 · DOI
  7. [8]Fazi F Rosa A Fatica A Gelmetti V De Marchis ML Nervi C Bozzoni I 2005 A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis Cell 123 819 831 10.1016/j.cell.2005.09.023 16325577 · DOI
  8. [9]Fenoglio C Ridolfi E Cantoni C De Riz M Bonsi R Serpente M Villa C Pietroboni AM Naismith RT Alvarez E 2013 Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis Mult Scler 19 1938 1942 10.1177/1352458513485654 24277735 · DOI
  9. [10]Fletcher JM Lalor SJ Sweeney CM Tubridy N Mills KH 2010 T cells in multiple sclerosis and experimental autoimmune encephalomyelitis Clin Exp Immunol 162 1 11 10.1111/j.1365-2249.2010.04143.x 20682002 PMC2990924 · DOI
  10. [11]Gabrilovich DI Ostrand-Rosenberg S Bronte V 2012 Coordinated regulation of myeloid cells by tumours Nat Rev Immunol 12 253 268 10.1038/nri3175 22437938 PMC3587148 · DOI · Paper page
  11. [12]Gilicze AB Wiener Z Toth S Buzas E Pallinger E Falcone FH Falus A 2014 Myeloid-derived microRNAs, miR-223, miR27a, and miR-652, are dominant players in myeloid regulation Biomed Res Int 2014 870267 10.1155/2014/870267 25177699 PMC4142666 · DOI
  12. [13]Gimenez MA Sim J Archambault AS Klein RS Russell JH 2006 A tumor necrosis factor receptor 1-dependent conversation between central nervous system-specific T cells and the central nervous system is required for inflammatory infiltration of the spinal cord Am J Pathol 168 1200 1209 10.2353/ajpath.2006.050332 16565495 PMC1606568 · DOI
  13. [14]Guerau-de-Arellano M Alder H Ozer HG Lovett-Racke A Racke MK 2012 miRNA profiling for biomarker discovery in multiple sclerosis: from microarray to deep sequencing J Neuroimmunol 248 32 39 10.1016/j.jneuroim.2011.10.006 22078708 PMC3288464 · DOI
  14. [15]Guerau-de-Arellano M Liu Y Meisen WH Pitt D Racke MK Lovett-Racke AE 2015 Analysis of miRNA in normal appearing white matter to identify altered CNS pathways in multiple sclerosis J Autoimmune Disord 1 1 8 PMC4755487 26894232
  15. [16]Hoechst B Gamrekelashvili J Manns MP Greten TF Korangy F 2011 Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells Blood 117 6532 6541 10.1182/blood-2010-11-317321 21493801 · DOI
  16. [17]Ifergan I Chen S Zhang B Miller SD 2016 Cutting edge: microRNA-223 regulates myeloid dendritic cell-driven Th17 responses in experimental autoimmune encephalomyelitis J Immunol 196 1455 1459 10.4049/jimmunol.1501965 26783338 PMC4744529 · DOI
  17. [18]Ioannou M Alissafi T Lazaridis I Deraos G Matsoukas J Gravanis A Mastorodemos V Plaitakis A Sharpe A Boumpas D 2012 Crucial role of granulocytic myeloid-derived suppressor cells in the regulation of central nervous system autoimmune disease J Immunol 188 1136 1146 10.4049/jimmunol.1101816 22210912 · DOI
  18. [20]Johnnidis JB Harris MH Wheeler RT Stehling-Sun S Lam MH Kirak O Brummelkamp TR Fleming MD Camargo FD 2008 Regulation of progenitor cell proliferation and granulocyte function by microRNA-223 Nature 451 1125 1129 10.1038/nature06607 18278031 · DOI · Paper page
  19. [21]Junker A Hohlfeld R Meinl E 2011 The emerging role of microRNAs in multiple sclerosis Nat Rev Neurol 7 56 59 10.1038/nrneurol.2010.179 21151203 · DOI · Paper page
  20. [22]Junker A Krumbholz M Eisele S Mohan H Augstein F Bittner R Lassmann H Wekerle H Hohlfeld R Meinl E 2009 Micro-RNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47 Brain J Neurol 132 3342 3352 10.1093/brain/awp300 19952055 · DOI · Paper page
  21. [23]Keller A Leidinger P Lange J Borries A Schroers H Scheffler M Lenhof HP Ruprecht K Meese E 2009 Multiple sclerosis: microRNA expression profiles accurately differentiate patients with relapsing-remitting disease from healthy controls PLoS One 4 e7440 10.1371/journal.pone.0007440 19823682 PMC2757919 · DOI
  22. [24]Kiernan JA 1984 Chromoxane cyanine R. II. Staining of animal tissues by the dye and its iron complexes J Microsc 134 25 39 6201616
  23. [25]King IL Dickendesher TL Segal BM 2009 Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease Blood 113 3190 3197 10.1182/blood-2008-07-168575 19196868 PMC2665891 · DOI · Paper page
  24. [26]Kotsakis A Harasymczuk M Schilling B Georgoulias V Argiris A Whiteside TL 2012 Myeloid-derived suppressor cell measurements in fresh and cryopreserved blood samples J Immunol Methods 381 14 22 10.1016/j.jim.2012.04.004 22522114 PMC3385927 · DOI
  25. [27]Kumar V Patel S Tcyganov E Gabrilovich DI 2016 The nature of myeloid-derived suppressor cells in the tumor microenvironment Trends Immunol 37 208 220 10.1016/j.it.2016.01.004 26858199 PMC4775398 · DOI · Paper page
  26. [28]Lewis BP Burge CB Bartel DP 2005 Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets Cell 120 15 20 10.1016/j.cell.2004.12.035 15652477 · DOI · Paper page
  27. [29]Li T Morgan MJ Choksi S Zhang Y Kim YS Liu ZG 2010 MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation Nat Immunol 11 799 805 10.1038/ni.1918 20711193 PMC2926307 · DOI
  28. [30]Liu Q Zhang M Jiang X Zhang Z Dai L Min S Wu X He Q Liu J Zhang Y 2011 miR-223 suppresses differentiation of tumor-induced CD11b(+) Gr1(+) myeloid-derived suppressor cells from bone marrow cells Int J Cancer 129 2662 2673 10.1002/ijc.25921 21213211 · DOI
  29. [31]Moline-Velazquez V Cuervo H Vila-Del Sol V Ortega MC Clemente D de Castro F 2011 Myeloid-derived suppressor cells limit the inflammation by promoting T lymphocyte apoptosis in the spinal cord of a murine model of multiple sclerosis Brain Pathol 21 678 691 10.1111/j.1750-3639.2011.00495.x 21507122 PMC8094047 · DOI
  30. [32]Moline-Velazquez V Vila-Del Sol V de Castro F Clemente D 2016 Myeloid cell distribution and activity in multiple sclerosis Histol Histopathol 31 357 370 10.14670/HH-11-699 26592711 · DOI
  31. [33]Nagaraj S Youn JI Gabrilovich DI 2013 Reciprocal relationship between myeloid-derived suppressor cells and T cells J Immunol 191 17 23 10.4049/jimmunol.1300654 23794702 PMC3694485 · DOI
  32. [34]Novitskiy SV Pickup MW Gorska AE Owens P Chytil A Aakre M Wu H Shyr Y Moses HL 2011 TGF-beta receptor II loss promotes mammary carcinoma progression by Th17 dependent mechanisms Cancer Discov 1 430 441 10.1158/2159-8290.CD-11-0100 22408746 PMC3297196 · DOI
  33. [35]O’Connell RM Zhao JL Rao DS 2011 MicroRNA function in myeloid biology Blood 118 2960 2969 10.1182/blood-2011-03-291971 21725054 PMC3175776 · DOI
  34. [36]Parekh VV Wu L Olivares-Villagomez D Wilson KT Van Kaer L 2013 Activated invariant NKT cells control central nervous system autoimmunity in a mechanism that involves myeloid-derived suppressor cells J Immunol 190 1948 1960 10.4049/jimmunol.1201718 23345328 PMC3577977 · DOI
  35. [37]Peranzoni E Zilio S Marigo I Dolcetti L Zanovello P Mandruzzato S Bronte V 2010 Myeloid-derived suppressor cell heterogeneity and subset definition Curr Opin Immunol 22 238 244 10.1016/j.coi.2010.01.021 20171075 · DOI
  36. [38]Piccio L Cantoni C Henderson JG Hawiger D Ramsbottom M Mikesell R Ryu J Hsieh CS Cremasco V Haynes W 2013 Lack of adiponectin leads to increased lymphocyte activation and increased disease severity in a mouse model of multiple sclerosis Eur J Immunol 43 2089 2100 10.1002/eji.201242836 23640763 PMC3901539 · DOI
  37. [39]Piccio L Stark JL Cross AH 2008 Chronic calorie restriction attenuates experimental autoimmune encephalomyelitis J Leukoc Biol 84 940 948 10.1189/jlb.0208133 18678605 PMC2638732 · DOI
  38. [41]Procaccini C De Rosa V Pucino V Formisano L Matarese G 2015 Animal models of multiple sclerosis Eur J Pharmacol 759 182 191 10.1016/j.ejphar.2015.03.042 25823807 PMC7094661 · DOI
  39. [42]Ridolfi E Fenoglio C Cantoni C Calvi A De Riz M Pietroboni A Villa C Serpente M Bonsi R Vercellino M 2013 Expression and genetic analysis of microRNAs involved in multiple sclerosis Int J Mol Sci 14 4375 4384 10.3390/ijms14034375 23439547 PMC3634436 · DOI
  40. [43]Rumble JM Huber AK Krishnamoorthy G Srinivasan A Giles DA Zhang X Wang L Segal BM 2015 Neutrophil-related factors as biomarkers in EAE and MS J Exp Med 212 23 35 10.1084/jem.20141015 25559893 PMC4291533 · DOI
  41. [44]Sullivan RP Leong JW Schneider SE Ireland AR Berrien-Elliott MM Singh A Schappe T Jewell BA Sexl V Fehniger TA 2015 MicroRNA-15/16 antagonizes Myb to control NK cell maturation J Immunol 195 2806 2817 10.4049/jimmunol.1500949 26268657 PMC4561212 · DOI
  42. [45]Vasquez-Dunddel D Pan F Zeng Q Gorbounov M Albesiano E Fu J Blosser RL Tam AJ Bruno T Zhang H 2013 STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients J Clin Investig 123 1580 1589 10.1172/JCI60083 23454751 PMC3613901 · DOI
  43. [46]Yi H Guo C Yu X Zuo D Wang XY 2012 Mouse CD11b+ Gr-1+ myeloid cells can promote Th17 cell differentiation and experimental autoimmune encephalomyelitis J Immunol 189 4295 4304 10.4049/jimmunol.1200086 23034169 PMC3478426 · DOI
  44. [47]Zhou L Lopes JE Chong MM Ivanov II Min R Victora GD Shen Y Du J Rubtsov YP Rudensky AY 2008 TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function Nature 453 236 240 10.1038/nature06878 18368049 PMC2597437 · DOI
  45. [48]Zhu B Bando Y Xiao S Yang K Anderson AC Kuchroo VK Khoury SJ 2007 CD11b+ Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis J Immunol 179 5228 5237 17911608
  46. [49]Zhu B Kennedy JK Wang Y Sandoval-Garcia C Cao L Xiao S Wu C Elyaman W Khoury SJ 2011 Plasticity of Ly-6C(hi) myeloid cells in T cell regulation J Immunol 187 2418 2432 10.4049/jimmunol.1100403 21824867 PMC3159773 · DOI

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Authors
Cantoni, C., Cignarella, F., Ghezzi, L., Mikesell, B., Bollman, B., Berrien-Elliott, M. M., Ireland, A. R., Fehniger, T. A., Wu, G. F., & Piccio, L.
Venue
Acta Neuropathologica
Published
2016-10-04
Volume
133
Issue
1
Pages
61-77
ISSN
  • 0001-6322
  • 1432-0533
Cited by
91
References
3
Language
en
Funders
  • Fondazione Italiana Sclerosi Multipla, FISM (2014/R/15, 2012/B/1)
  • National Multiple Sclerosis Society (FG 2010-A1/2, JF 2144A2/1)
  • Foundation for the National Institutes of Health (R01NS083678, R01AI102924)

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