Pancreatic cancer in Lynch syndrome patients
Open accessAbstract
Although colorectal cancer (CRC) is the most common cancer type in Lynch syndrome (LS) families, patients have also increased lifetime risk of other types of tumors. The accumulated risk of pancreatic cancer (PC) in LS patients is around 3.7% and developed tumors often present a characteristically medullary appearance with prominent lymphocytic infiltration. LS patients are considered in high risk for PC development as they present 8.6-fold increase compared with the general population. Here we review PC cases reported in LS patients and current management guidelines. Literature data show that LS is clearly associated with PC and recent publications also demonstrated a connection with pancreatic neoplasic precursor lesions such as intraductal papillary mucinous neoplasms (IPMN) in these patients. While screening techniques are well established for CRC detection, clear strategies are not yet uniform for PC. Magnetic resonance imaging (MRI) and/or endoscopic ultrasound every 1-2 years in MMR mutation carriers with PC in a first or second-degree relative is recommended. Better pancreatic cancer detection strategies should be urgently defined due to the importance of early diagnosis in this disease.
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- Authors
- Bujanda, L., & Herreros-Villanueva, M.
- Venue
- Journal of Cancer
- Publisher
- Ivyspring International Publisher
- Published
- 2017
- Volume
- 8
- Issue
- 18
- Pages
- 3667-3674
- ISSN
- 1837-9664 (ISSN-L)
- PMC
- PMC5688919
- OpenAlex
- W2766055500
- Cited by
- 57
- References
- 59
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 9 · 2023: 8 · 2022: 8 · 2021: 8 · 2020: 8 · 2019: 4 · 2018: 2
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Journal of Cancer (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Communities in ADDI (Universidad del Pais Vasco) (submittedVersion, other-oa)
- Communities in ADDI (University of the Basque Country) (submittedVersion, cc-by-nc)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc)
- Hispana (submittedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Keywords
- Lynch syndrome, pancreatic cancer, intraductal papillary mucinous neoplasm, pancreatic cancer screening, endoscopic ultrasound, magnetic resonance imaging, early diagnosis, lifetime cancer risk
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