The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
The Glycolytic Switch in Tumors: How Many Players Are Involved?
Open accessAbstract
Reprogramming of cellular metabolism is a hallmark of cancers. Cancer cells more readily use glycolysis, an inefficient metabolic pathway for energy metabolism, even when sufficient oxygen is available. This reliance on aerobic glycolysis is called the Warburg effect, and promotes tumorigenesis and malignancy progression. The mechanisms of the glycolytic shift in tumors are not fully understood. Growing evidence demonstrates that many signal molecules, including oncogenes and tumor suppressors, are involved in the process, but how oncogenic signals attenuate mitochondrial function and promote the switch to glycolysis remains unclear. Here, we summarize the current information on several main mediators and discuss their possible mechanisms for triggering the Warburg effect.
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Citations
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Altered metabolism in cancer: insights into energy pathways and therapeutic targets
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Targeting mitochondrial metabolism for precision medicine in cancer
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Metadata
- Authors
- Yu, L., Chen, X., Sun, X., Wang, L., & Chen, S.
- Venue
- Journal of Cancer
- Publisher
- Ivyspring International Publisher
- Published
- 2017
- Volume
- 8
- Issue
- 17
- Pages
- 3430-3440
- ISSN
- 1837-9664 (ISSN-L)
- OpenAlex
- W2759858864
- Cited by
- 233
- References
- 22
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- gold
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