The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Polydopamine-Based Surface Modification of Novel Nanoparticle-Aptamer Bioconjugates for In Vivo Breast Cancer Targeting and Enhanced Therapeutic Effects
Open accessAbstract
In this study, we reported a simple polydopamine (pD)-based surface modification method to prepare novel nanoparticle-aptamer bioconjugates (Apt-pD-DTX/NPs) for in vivo tumor targeting and enhanced therapeutic effects of breast cancer. With simple preparation procedures, the new functionalized Apt-pD-DTX/NPs could maximumly increase the local effective drug concentration on tumor sites, achieving enhanced treatment effectiveness and minimizing side effects. The dopamine polymerization and aptamer conjugation barely changed the characters of NPs. Both in vitro cell experiments (i.e. endocytosis of fluorescent NPs, in vitro cellular targeting and cytotoxicity assays) and in vivo animal studies (i.e. in vivo imaging, biodistribution and antitumor effects of NPs) demonstrated that the Apt-pD-DTX/NPs could achieve significantly high targeting efficiency and enhanced therapeutic effects compared with clinical Taxotere(®) and NPs without functional modification. Above all, the Apt-pD-DTX/NPs showed great potential as a promising nanoformulation for in vivo breast cancer therapy and the construction of pD-modified NP-aptamer bioconjugates could be of great value in medical use.
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Cites
Mussel-inspired surface chemistry for multifunctional coatings
Lee, H., Dellatore, S. M., Miller, W. M., & Messersmith, P. B. (2007) · Science · doi:10.1126/science.1147241 · Cited by 10,965
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Jiang, J., Zhu, L., Zhu, L., Zhu, B., & Xu, Y. (2011) · Langmuir · doi:10.1021/la202877k · Cited by 750
Polydopamine-Based Simple and Versatile Surface Modification of Polymeric Nano Drug Carriers
Park, J., Brust, T. F., Lee, H. J., Lee, S. C., Watts, V. J., & Yeo, Y. (2014) · ACS Nano · doi:10.1021/nn405809c · Cited by 407
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Self-citationPolydopamine Surface Chemistry: A Decade of Discovery
Ryu, J. H., Messersmith, P. B., & Lee, H. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b19865 · Cited by 1,843
Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles
Foroozandeh, P., & Aziz, A. A. (2018) · Nanoscale Research Letters · doi:10.1186/s11671-018-2728-6 · Cited by 1,377
Zeng, X., Luo, M., Liu, G., Wang, X., Tao, W., Lin, Y., Ji, X., Nie, L., & Mei, L. (2018) · Advanced Science · doi:10.1002/advs.201800510 · Cited by 598
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Metadata
- Authors
- Tao, W., Zeng, X., Wu, J., Zhu, X., Yu, X., Zhang, X., Zhang, J., Liu, G., & Mei, L.
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2016
- Volume
- 6
- Issue
- 4
- Pages
- 470-484
- ISSN
- 1838-7640 (ISSN-L)
- OpenAlex
- W2325992502
- Cited by
- 203
- References
- 4
- FWCI
- 12.40
- Type
- journal article
- Language
- en
- Open access
- gold
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- Tao, W., Zeng, X., Wu, J., Zhu, X., Yu, X., Zhang, X., Zhang, J., Liu, G., & Mei, L. (2016). Polydopamine-Based Surface Modification of Novel Nanoparticle-Aptamer Bioconjugates for In Vivo Breast Cancer Targeting and Enhanced Therapeutic Effects. Theranostics. https://doi.org/10.7150/thno.14184
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