The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes
Open accessAbstract
Ferroptosis is a newly discovered form of non-apoptotic cell death in multiple human diseases.However, the epigenetic mechanisms underlying ferroptosis remain poorly defined.First, we demonstrated that lymphoid-specific helicase (LSH), which is a DNA methylation modifier, interacted with WDR76 to inhibit ferroptosis by activating lipid metabolism-associated genes, including GLUT1, and ferroptosis related genes SCD1 and FADS2, in turn, involved in the Warburg effect.WDR76 targeted these genes expression in dependent manner of LSH and chromatin modification in DNA methylation and histone modification.These effects were dependent on iron and lipid reactive oxygen species.We further demonstrated that EGLN1 and c-Myc directly activated the expression of LSH by inhibiting HIF-1α.Finally, we demonstrated that LSH functioned as an oncogene in lung cancer in vitro and in vivo.Therefore, our study elucidates the molecular basis of the c-Myc/EGLN1-mediated induction of LSH expression that inhibits ferroptosis, which can be exploited for the development of therapeutic strategies targeting ferroptosis for the treatment of cancer.
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Cites
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
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Regulation of Ferroptotic Cancer Cell Death by GPX4
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“Reprogramming of cellular metabolism, including the regulation of apoptotic and necrotic cell death, is necessary for tumorigenesis [1-3].”
BackgroundHIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
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Ferroptosis as a p53-mediated activity during tumour suppression
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The role of iron and reactive oxygen species in cell death
Dixon, S. J., & Stockwell, B. R. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1416 · Cited by 2,381
Dixon, S. J., Patel, D. N., Welsch, M., Skouta, R., Lee, E. D., Hayano, M., Thomas, A. G., Gleason, C. E., Tatonetti, N. P., Slusher, B. S., et al. (2014) · eLife · doi:10.7554/elife.02523 · Cited by 2,088
Glutaminolysis and transferrin regulate ferroptosis
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Cited by
Ferroptosis: machinery and regulation
Chen, X., Li, J., Kang, R., Klionsky, D. J., & Tang, D. (2021) · Autophagy · doi:10.1080/15548627.2020.1810918 · Cited by 2,099
Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion
Friedmann Angeli, J. P., Krysko, D. V., & Conrad, M. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0149-1 · Cited by 1,259
Zou, Y., Palte, M. J., Deik, A. A., Li, H., Eaton, J. K., Wang, W., Tseng, Y.-Y., Deasy, R., Kost-Alimova, M., Dančík, V., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09277-9 · Cited by 887
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Self-citationLi, F.-J., Long, H.-Z., Zhou, Z.-W., Luo, H.-Y., Xu, S.-G., & Gao, L.-C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.910292 · Cited by 438
Metadata
- Authors
- Jiang, Y., Mao, C., Yang, R., Yan, B., Shi, Y., Liu, X., Lai, W., Liu, Y., Wang, X., Xiao, D., Zhou, H., Cheng, Y., Yu, F., Cao, Y., Liu, S., Yan, Q., & Tao, Y.
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2017
- Volume
- 7
- Issue
- 13
- Pages
- 3293-3305
- ISSN
- 1838-7640 (ISSN-L)
- OpenAlex
- W2740317277
- Cited by
- 292
- References
- 58
- FWCI
- 8.71
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes. https://app.cochat.ai/papers/10.7150/thno.19988
- The paper
- Jiang, Y., Mao, C., Yang, R., Yan, B., Shi, Y., Liu, X., Lai, W., Liu, Y., Wang, X., Xiao, D., Zhou, H., Cheng, Y., Yu, F., Cao, Y., Liu, S., Yan, Q., & Tao, Y. (2017). EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes. Theranostics. https://doi.org/10.7150/thno.19988
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
