Adipocyte-Derived Exosomal MiR-27a Induces Insulin Resistance in Skeletal Muscle Through Repression of PPARγ
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These results identify a novel crosstalk signaling pathway between adipose tissue and skeletal muscle in the development of insulin resistance, and indicate that adipose tissue-derived miR-27a may play a key role in the development of obesity-triggered insulin resistance in skeletal muscle.
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MicroRNAs located in exosomes of adipocytes and macrophages of adipose tissue and secreted into circulation can influence the development of insulin resistance through mechanisms such as inhibition of PPAR-gamma expression and affecting PI3K/AKT-GLUT4 signaling pathway.
“Studies show that these particles, located in exosomes of adipocytes and macrophages of adipose tissue and secreted from them into the circulation, can influence the development of IR through mechanisms, such as inhibition of peroxisome proliferator-activated receptor (PPAR-gamma) expression and affecting PI3K/AKT-GLUT4 signaling pathway [57,58,59].”
From The Role of Glp-1 Receptor Agonists in Insulin Resistance with Concomitant Obesity Treatment in Polycystic Ovary Syndrome (2022) · cites this paper as [58]
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- Authors
- Yu, Y., Du, H., Wei, S., Feng, L., Li, J., Yao, F., Zhang, M., Hatch, G. M., & Chen, L.
- Affiliations
- Jilin University (CN)
- Children's Hospital Research Institute of Manitoba (CA)
- Corresponding author
- Zhang, Ming
- Chen, Li
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2018
- Volume
- 8
- Issue
- 8
- Pages
- 2171-2188
- ISSN
- 1838-7640 (ISSN-L)
- PMC
- PMC5928879
- OpenAlex
- W2790735034
- Cited by
- 330
- References
- 45
- Citations by year
- 2026: 33 · 2025: 52 · 2024: 42 · 2023: 58 · 2022: 45 · 2021: 47 · 2020: 29 · 2019: 20 · 2018: 4
- FWCI
- 8.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Theranostics (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Jilin University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- miR-27a, exosomes, adipocytes, skeletal muscle, insulin resistance, PPARγ, obesity, microRNA
- MeSH terms
- Adolescent, Animals, Base Sequence, Cell Line, Child, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Macrophages, Male, Mice, Inbred C57BL, Obesity, Signal Transduction, Adipocytes, Muscle, Skeletal, Palmitic Acid, MicroRNAs, PPAR gamma, Adipokines, Exosomes, Diet, High-Fat
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