Calcium phosphate engineered photosynthetic microalgae to combat hypoxic-tumor by in-situ modulating hypoxia and cascade radio-phototherapy
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Our studies of this photosynthetic microsystem open up a new dimension for solving the radioresistance issue of hypoxic tumors.
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Living C. vulgaris cells engineered for in situ O2 generation relieved tumor-bearing mice hypoxia and enhanced radiotherapeutic effect, with cascade phototherapy from released chlorophyll under 650 nm laser irradiation.
“Living C. vulgaris cells were engineered for an in situ generation of O2 to relieve tumor-bearing mice hypoxia, enhancing radiotherapeutic effect [167].”
From Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. (2023) · cites this paper as [167]
The engineered C. vulgaris treatment showed prominent antitumor and antimetastasis efficacy in an orthotropic breast cancer mouse model in hypoxic-tumor management.
“The treatment was validated in an orthotropic breast cancer mouse model, revealing its prominent antitumor and antimetastasis efficacy in hypoxic-tumor management.”
From Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. (2023) · cites this paper as [167]
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- Authors
- Zhong, D., Li, W., Hua, S., Qi, Y., Xie, T., Qiao, Y., & Zhou, M.
- Affiliations
- Zhejiang University (CN)
- State Key Laboratory of Modern Optical Instruments (CN)
- Corresponding author
- Zhou, Min
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2021
- Volume
- 11
- Issue
- 8
- Pages
- 3580-3594
- ISSN
- 1838-7640 (ISSN-L)
- PMC
- PMC7914342
- OpenAlex
- W3127403149
- Cited by
- 76
- References
- 44
- Citations by year
- 2026: 15 · 2025: 13 · 2024: 19 · 2023: 13 · 2022: 11 · 2021: 5
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Theranostics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
- Keywords
- calcium phosphate, photosynthetic microalgae, hypoxic tumors, radioresistance (biology), local drug delivery, photodynamic therapy
- MeSH terms
- Tumor Hypoxia, Biomineralization, Animals, Calcium Phosphates, Combined Modality Therapy, Female, Mammary Neoplasms, Experimental, Mice, Inbred BALB C, Oxygen, Photosynthesis, Phototherapy, Tumor Stem Cell Assay, Biomimetics, Cell Line, Tumor, Chlorella vulgaris, Mice, Precision Medicine, Microalgae, Photoacoustic Techniques
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