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STUDIES ON PENICILLINASE INHIBITORS PRODUCED BY MICROORGANISMS

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6 β-Lactamases: Targets for Drug Design

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Studies on the stereospecificity of the clavaminic acid synthase catalysed hydroxylation reaction

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A gene located downstream of the clavulanic acid gene cluster in Streptomyces clavuligerus ATCC 27064 encodes a putative response regulator that affects clavulanic acid production

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Synergistic Antibacterial Activity of Clavulanic Acid and Amoxicillin Against β-Lactamase-Producing Strains of Haemophilus ducreyi

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Activities and sources of beta-lactamase in sputum from patients with bronchiectasis

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Pharmacokinetic studies and renal dehydropeptidase stability of the new beta-lactamase inhibitor BRL 42715 in animals

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Improved High Performance Liquid Chromatographic Assay of Clavulanic Acid And Sulbactam by Postcolumn Alkaline Degradation

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Complete Genome Sequence of Streptomyces clavuligerus F613-1, an Industrial Producer of Clavulanic Acid

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Enzyme Inhibition and Inactivation

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Clavulanic acid biosynthesis; the final steps

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Modern β-lactam antibiotics

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Screening of Inhibitory Monoclonal Antibodies: A Critical Step for Producing Anti‐idiotypic Catalytic Antibodies

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Synthesis of L-ornithines stereospecifically deuterated at C-3

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Absorption, metabolism and excretion studies on clavulanic acid in the rat and dog

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Studies on the biosynthesis of clavulanic acid. Part 4. Synthetic routes to the monocyclic β-lactam precursor, proclavaminic acid

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Fed-batch cultivation for the production of clavulanic acid by an immobilized Streptomyces clavuligerus mutant

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The synthesis and serine β-lactamase inhibitory activity of some phosphonamidate analogues of dipeptides

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Determination of benzylpenicillin in plasma and lymph at the ng ml−1 level by reversed-phase liquid chromatography in combination with digital subtraction chromatography technique

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Meropenem: laboratory and clinical data

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Induction of Holomycin Production and Complex Metabolic Changes by the argR Mutation in Streptomyces clavuligerus NP1

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Removal of potassium chloride by nanofiltration from ion-exchanged solution containing potassium clavulanate

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Inversion of the stereochemical configuration (3S, 5S)-clavaminic acid into (3R, 5R)-clavulanic acid: A computationally-assisted approach based on experimental evidence

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Screening of medium constituents for clavulanic acid production by Streptomyces clavuligerus

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Correlation study of antibacterial activity and spectrum of Penicillins through a structure-activity relationship analysis

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Overcoming Bacterial Resistance: Role of β-Lactamase Inhibitors

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Pharmacokinetics of amoxicillin/clavulanic acid combination after intravenous and intramuscular administration to pigeons

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Chapter 30. Strategies in the Discovery of Drugs from Natural Sources

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Naturally Occurring β-Lactams

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A Controlled Trial of Amoxycillin with Clavulanic Acid (BRL 25000) against Doxycycline in Chronic Bronchitis

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Penicillin G's function, metabolites, allergy, and resistance.

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Inhibition of the RTEM-1 β-lactamase by boronic acids

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Intrinsic Kinetic Parameters of Clavulanic Acid Adsorption by Ion-Exchange Chromatography

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Comprehensive Overview of Antibacterial Drugs and Natural Antibacterial Compounds Found in Food Plants

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Simultaneous determination of ticarcillin and clavulanate in rabbit serum and tissue cage fluid by liquid chromatography

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Synthesis of 3-Substituted-clavams: Antifungal Properties, DD-Peptidase and β-Lactamase Inhibition

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Cloning and heterologous expression of the gene for BLIP-II, a -lactamase-inhibitory protein from Streptomyces exfoliatus SMF19

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Synthesis of 3α-alkoxy-4β-substituted-2-azetidinones from L(+)-tartaric acid.

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Synthesis of optically active penems - ii

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Synthesis, biological, and chiroptical activity of 3-phenyl-clavams

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Procedure for isolation of Thienamycin from fermentation broths

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β-Lactam Antibiotics: Structure-Activity Relationships

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THEORETICAL STUDIES OF β‐LACTAM ANTIBIOTICS*

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Enhanced biosynthesis of clavulanic acid in Streptomyces clavuligerus due to oxidative challenge by redox-cycling agents

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Clavulanic Acid and its Potential Therapeutic Effects on the Central Nervous System

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Robustifying Experimental Tracer Design for13C-Metabolic Flux Analysis

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A case of allergic contact dermatitis to clavulanic acid

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Synthesis of Cu(II) complex with schiff bases derived from aryl-S-benzyildithiocarbazate: Antimicrobial activity and in silico biological properties evaluations

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Strategies in β-lactam Design

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Medicinal Chemistry of β‐Lactam Antibiotics

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Application of Acid and Cold Stresses to Enhance the Production of Clavulanic Acid by Streptomyces clavuligerus

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TCA Cycle and Its Relationship with Clavulanic Acid Production: A Further Interpretation by Using a Reduced Genome-Scale Metabolic Model of Streptomyces clavuligerus

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Heterologous production of clavulanic acid intermediates in Streptomyces venezuelae

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Characteristics of beta-lactamase-inhibiting proteins from Streptomyces exfoliatus SMF19

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Continuous Clavulanic Acid Adsorption Process

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Effect of a β-lactamase inhibitor, tazobactam, on growth and penicillin-binding proteins of Borrelia burgdorferi

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Removal of potassium chloride from ion-exchanged solution containing potassium clavulanate by diafiltration with nanomembrane and its modeling

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Chemotherapy of bacterial plasmids

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Factors Governing Intrinsic Chemical Reactivity Differences between Clavulanic and Penicillanic Acids

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In- VitroActivity of Meropenem, a New Carbapenem, Against Imipenem-ResistantPseudomonas aeruginosaandXanthomonas maltophilia

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Antibiotics affecting bacterial wall synthesis

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In vitro-activity of clavulanic acid and amoxicillin combined against amoxicillin-resistant bacteria

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The Synthesis of the β‐Lactam Function

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β-Lactam-Producing Microorganisms: Their Biology and Fermentation Behavior

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The use of aminopenicillins in animals within the EU, emergence of resistance in bacteria of animal and human origin and its possible impact on animal and human health

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Antibiotics and Drug Pharmacology

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In vitro Effect of the Combination of Aztreonam and Amoxicillin/Clavulanic Acid Against Carbapenem-Resistant Gram-Negative Organisms Producing Metallo-β-Lactamase

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The Extended-Spectrum K1 β-Lactamase from Klebsiella oxytoca SC 10,436 Is a Member of the bla OXY-2 Family of Chromosomal Klebsiella Enzymes

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Recent development and future directions of enzyme technology in Japan

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Recovery of potassium clavulanate from fermentation broth by ion exchange chromatography and desalting electrodialysis

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The Evolution of β‐Lactamases

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Some Inherently Chiral Chromophores—Empirical Rules and Quantum Chemical Calculations

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The chemistry of clavulanic acid: Some reactions of esters under neutral, acidic and basic conditions

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Mycobacterium tuberculosis β-lactamase variant reduces sensitivity to ampicillin/avibactam in a zebrafish-Mycobacterium marinum model of tuberculosis

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Screening of wild type Streptomyces isolates able to overproduce clavulanic acid

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Using redox potential to detect microbial activities during clavulanic acid biosynthesis in Streptomyces clavuligerus

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Case Studies in Drug Discovery

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Penicillin G's function, metabolites, allergy, and resistance.

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Coordination of glycerol utilization and clavulanic acid biosynthesis to improve clavulanic acid production in Streptomyces clavuligerus

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Biosynthesis of p-Lactam Antibiotics

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The Chemistry of 2‐Azetidinones (β‐Lactams)

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New Inhibitors for Aminoglycoside-Adenylyltransferase

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Stérilisation par 2 grammes d'Augmentin® des urines infectées à Staphylococcus aureus résistant à la méticilline

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Automated enzyme-inhibition assay for clavulanic acid in biological samples

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Anti-β-Lactamase Agents

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Pharmacokinetics of β-Lactam Antibiotics

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Microalgae, Cell Factories for Antimicrobial Peptides: A Promising Response to Antibiotic Resistance

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β-Lactamase inhibitors: a survey of the patent literature 2000 – 2004

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The isolation and improvement of industrially important microorganisms

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MOLECULAR AND MORPHOLOGICAL IDENTIFICATION OF STREPTOMYCES SP. NRC-88 NOVA SPECIES AS β-LACTAMASE INHIBITOR FOR PHARMACEUTICAL APPLICATION

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Enzymatic Synthesis of Penicillins

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Clavulanic Acid Adsorption Studies in Zeolites

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Reaction of Clavams with Elastase Reveals a General Method for Inhibiting ‘Serine’ Enzymes

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Actinomicetos produtores de inibidores de β-lactamases com atividade antimicrobiana frente a isolados de mastite bovina

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