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Cited by 148Pharmacology and Obesity TreatmentObesity and Health PracticesObesity, Physical Activity, Diet

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Comparison of Methods for Delivering a Lifestyle Modification Program for Obese Patients: A Randomized Trial

Digenio, Andres G., Mancuso, James P., Gerber, Robert A., Dvorak, Roman V.·2009·Annals of Internal Medicine
DOI 10.7326/0003-4819-150-4-200902170-00006
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Abstract

BACKGROUND: Physicians frequently prescribe medications for weight loss but offer minimal lifestyle counseling despite the additional benefits of combining both interventions. OBJECTIVE: To compare 5 methods of delivering a lifestyle modification program to obese patients receiving sibutramine. DESIGN: Randomized, 6-month, open-label study. Participants were assigned to intervention groups by using a computer-generated schedule of randomly permuted blocks. Block length was 5. SETTING: 12 independent research clinics with experience running obesity trials. PATIENTS: 376 patients with obesity (body mass index > or =30 and <40 kg/m(2)). INTERVENTION: High-frequency face-to-face lifestyle modification counseling (HF-F2F) (n = 74), low-frequency face-to-face counseling (LF-F2F) (n = 76), high-frequency telephone counseling (HF-TEL) (n = 76), high-frequency e-mail counseling (HF-EMAIL) (n = 74), or no dietitian contact (self-help [SELF]) (n = 76). All participants received sibutramine, 10 mg/d; a lifestyle manual; and access to a weight-loss Web site. MEASUREMENTS: Percentage change in body weight at 6 months was the primary outcome. Secondary end points included changes in waist circumference; lipid, glucose, and insulin levels; blood pressure; weight-related symptoms; and quality of life at 6 months. RESULTS: At 6 months, the mean weight loss, relative to baseline, in the HF-F2F and HF-TEL groups was similar (8.9% [95% CI, 8.0% to 9.8%] and 7.7% [CI, 6.8% to 8.7%]) and significantly greater than that in the other groups (LF-F2F, 6.4% [CI, 5.4% to 7.3%]; HF-EMAIL, 5.9% [CI, 5.0% to 6.8%]; and SELF, 5.2% [CI, 4.3% to 6.1%]). All groups showed significant improvements in waist circumference, high-density lipoprotein cholesterol and triglyceride levels, and measures of quality of life and weight-related symptoms. There were no serious adverse events and no differences in minor events among groups. LIMITATION: Most participants were women, and the attrition rate was 30%. CONCLUSION: High-frequency telephone contact with a dietitian was similar to HF-F2F contact for supporting lifestyle modification in obese patients trying to lose weight. The findings might be used by providers and health systems to promote healthy lifestyle changes for their patients. FUNDING: Pfizer Global Research and Development.

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Crossref · 10.7326/0003-4819-150-4-200902170-00006

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  1. 1998, Obes Res, 6, 51S

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Metadata

Authors
Digenio, A. G., Mancuso, J. P., Gerber, R. A., & Dvorak, R. V.
Affiliations
Pfizer (United States) (US)
Corresponding author
Digenio, Andres G.
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
2009-02-17
Volume
150
Issue
4
Pages
255-262
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-150-4-200902170-00006
OpenAlex
W1973362692
Cited by
148
References
16
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 9 · 2020: 6 · 2019: 10 · 2018: 3 · 2017: 9 · 2016: 10 · 2015: 4 · 2014: 15 · 2013: 16 · 2012: 16
FWCI
13.65
Type
journal article
Language
en
Open access
closed
Licence
www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations
  • Annals of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity and Health Practices
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords
obesity, lifestyle modification, sibutramine, telephone counseling, email counseling, face-to-face counseling, weight loss, telephone-delivered intervention, self-help, waist circumference, serum lipids, quality of life, pharmacist counseling, attrition, obese women, blood pressure
MeSH terms
Adult, Appetite Depressants, Behavior Therapy, Combined Modality Therapy, Counseling, Cyclobutanes, Female, Humans, Life Style, Male, Middle Aged, Obesity, Patient Compliance, Patient Dropouts, Weight Loss, Treatment Outcome, Waist Circumference

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