Behavioral treatment of obesity
Open accessAbstract
This review has shown that behavioral treatment is effective in inducing a 10% weight loss, which is sufficient to significantly improve health. Weight loss maintenance is challenging for most patients. Long-term outcomes have the potential to be improved through various methods including prolonging contact between patients and providers (either in the clinic or via Internet or telephone), facilitating high amounts of physical activity, or combining lifestyle modification with pharmacotherapy. Innovative programs also are being developed to disseminate behavioral approaches beyond traditional academic settings.
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Lifestyle strategies are often insufficient to achieve and sustain weight loss.
“However, these strategies are often insufficient to achieve and sustain weight loss.9,10”
From The expanding role of GLP-1 receptor agonists: a narrative review of current evidence and future directions (2025) · cites this paper as [9]
On average, patients regain one-third of the weight lost (5-10% of baseline bodyweight) within the first year of treatment discontinuation, and nearly half return to their initial weight within five years.
“On average, patients regain one-third of the weight lost (5–10% of baseline bodyweight) within the first year of treatment discontinuation, and nearly half of patients return to their initial weight within five years.9”
From The expanding role of GLP-1 receptor agonists: a narrative review of current evidence and future directions (2025) · cites this paper as [9]
Monthly or more frequent weight-loss-maintenance therapy delays but does not prevent regain, particularly after treatment concludes.
“Monthly or more frequent weight-loss-maintenance therapy delays but does not prevent regain, particularly after treatment concludes [6, 30, 31].”
From The Role of Lifestyle Modification with Second-Generation Anti-obesity Medications: Comparisons, Questions, and Clinical Opportunities (2023) · cites this paper as [30]
Individuals regain a mean one-third of lost weight in the year following treatment discontinuation, with further regain over time.
“In addition, individuals regain a mean one-third of lost weight in the year following treatment discontinuation, with further regain over time [6, 30].”
From The Role of Lifestyle Modification with Second-Generation Anti-obesity Medications: Comparisons, Questions, and Clinical Opportunities (2023) · cites this paper as [30]
Lifestyle modification has limitations including plateauing of weight loss at 6-9 months.
“Limitations of lifestyle modification include the plateauing of weight loss at 6–9 months [30], even when participants still have obesity and may receive continued counseling [6, 31].”
From The Role of Lifestyle Modification with Second-Generation Anti-obesity Medications: Comparisons, Questions, and Clinical Opportunities (2023) · cites this paper as [30]
For chronic disorders such as obesity, a treatment that produces short-term weight loss may not produce long-term weight loss even if the individual continues the same treatment (within-person heterogeneity).
“Due to the waxing and waning course of many chronic disorders such as obesity [3], for example, a treatment that demonstrates short-term weight loss for an individual may not lead to weight loss in the long-term even if the individual remains on the same treatment (within-person heterogeneity; [4]).”
From Introduction to SMART designs for the development of adaptive interventions: with application to weight loss research (2014) · cites this paper as [4]
Most participants in behavioral weight loss treatments regain significant weight within one year and substantial or full weight within five years.
“Moreover, most experience significant weight regain within a year and substantial, if not full, regain within 5 years.4”
From The mind your health project: a randomized controlled trial of an innovative behavioral treatment for obesity (2013) · cites this paper as [4]
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- Authors
- Butryn, M. L., Webb, V., & Wadden, T. A.
- Affiliations
- Drexel University (US)
- University of Pennsylvania (US)
- Corresponding author
- Butryn, Meghan L.
- Venue
- Psychiatric Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 34
- Issue
- 4
- Pages
- 841-859
- ISSN
- 0193-953X (ISSN-L)
- PMC
- PMC3233993
- OpenAlex
- W2059332373
- Cited by
- 636
- References
- 197
- Citations by year
- 2026: 14 · 2025: 27 · 2024: 24 · 2023: 28 · 2022: 34 · 2021: 51 · 2020: 42 · 2019: 36 · 2018: 43 · 2017: 49 · 2016: 43 · 2015: 34 · 2014: 43 · 2013: 32 · 2012: 31
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatric Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5k24dk065018-10)
- National Institute of Diabetes and Digestive and Kidney Diseases (K24-DK-065018)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Health Professions › Pharmacy › Obesity and Health Practices
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Keywords
- obesity, behavior therapy, weight loss, weight loss maintenance, long-term outcomes, physical activity, lifestyle modification, pharmacotherapy, online intervention, telephone-delivered intervention
- MeSH terms
- Adult, Behavior Therapy, Combined Modality Therapy, Feeding Behavior, Female, Humans, Life Style, Motor Activity, Obesity, Therapy, Computer-Assisted, Weight Loss, Randomized Controlled Trials as Topic, Treatment Outcome, Telemedicine, Anti-Obesity Agents, Secondary Prevention, Weight Reduction Programs
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