The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Nascent-Seq reveals novel features of mouse circadian transcriptional regulation
Open accessAbstract
A substantial fraction of the metazoan transcriptome undergoes circadian oscillations in many cells and tissues. Based on the transcription feedback loops important for circadian timekeeping, it is commonly assumed that this mRNA cycling reflects widespread transcriptional regulation. To address this issue, we directly measured the circadian dynamics of mouse liver transcription using Nascent-Seq (genome-wide sequencing of nascent RNA). Although many genes are rhythmically transcribed, many rhythmic mRNAs manifest poor transcriptional rhythms, indicating a prominent contribution of post-transcriptional regulation to circadian mRNA expression. This analysis of rhythmic transcription also showed that the rhythmic DNA binding profile of the transcription factors CLOCK and BMAL1 does not determine the transcriptional phase of most target genes. This likely reflects gene-specific collaborations of CLK:BMAL1 with other transcription factors. These insights from Nascent-Seq indicate that it should have broad applicability to many other gene expression regulatory issues.
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Cites
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“Because these genes are associated with short or long mRNA half-lives, respectively, we compared the Nascent-Seq to RNA-Seq ratios of genes with their published mRNA half-lives (Sharova et al., 2009).”
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Cited by
Transcriptional architecture of the mammalian circadian clock
Takahashi, J. S. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2016.150 · Cited by 2,635
Molecular architecture of the mammalian circadian clock
Partch, C. L., Green, C. B., & Takahashi, J. S. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.07.002 · Cited by 1,449
Molecular mechanisms and physiological importance of circadian rhythms
Patke, A., Young, M. W., & Axelrod, S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0179-2 · Cited by 1,388
Circadian time signatures of fitness and disease
Bass, J., & Lazar, M. A. (2016) · Science · doi:10.1126/science.aah4965 · Cited by 607
Robles, M. S., Cox, J., & Mann, M. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004047 · Cited by 383
Metadata
- Authors
- Menet, J. S., Rodriguez, J., Abruzzi, K. C., & Rosbash, M.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2012-11-13
- Volume
- 1
- Pages
- e00011-e00011
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2096352618
- Cited by
- 319
- References
- 7
- FWCI
- 10.47
- Type
- journal article
- Language
- en
- Open access
- gold
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