The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
HIV-1 DNA predicts disease progression and post-treatment virological control
Open accessAbstract
In HIV-1 infection, a population of latently infected cells facilitates viral persistence despite antiretroviral therapy (ART). With the aim of identifying individuals in whom ART might induce a period of viraemic control on stopping therapy, we hypothesised that quantification of the pool of latently infected cells in primary HIV-1 infection (PHI) would predict clinical progression and viral replication following ART. We measured HIV-1 DNA in a highly characterised randomised population of individuals with PHI. We explored associations between HIV-1 DNA and immunological and virological markers of clinical progression, including viral rebound in those interrupting therapy. In multivariable analyses, HIV-1 DNA was more predictive of disease progression than plasma viral load and, at treatment interruption, predicted time to plasma virus rebound. HIV-1 DNA may help identify individuals who could safely interrupt ART in future HIV-1 eradication trials. Clinical trial registration: ISRCTN76742797 and EudraCT2004-000446-20
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Cites
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
Finzi, D., Hermankova, M., Pierson, T., Carruth, L. M., Buck, C., Chaisson, R. E., Quinn, T. C., Chadwick, K., Margolick, J., Brookmeyer, R., et al. (1997) · Science · doi:10.1126/science.278.5341.1295 · Cited by 3,098
Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
Wong, J. K., Hezareh, M., Günthard, H. F., Havlir, D. V., Ignacio, C. C., Spina, C. A., & Richman, D. D. (1997) · Science · doi:10.1126/science.278.5341.1291 · Cited by 2,186
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Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV
Tebas, P., Stein, D., Tang, W. W., Frank, I., Wang, S. Q., Lee, G., Spratt, S. K., Surosky, R. T., Giedlin, M. A., Nichol, G., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1300662 · Cited by 1,357
Chun, T.-W., Justement, J. S., Murray, D., Hallahan, C. W., Maenza, J., Collier, A. C., Sheth, P. M., Kaul, R., Ostrowski, M., Moir, S., et al. (2010) · AIDS · doi:10.1097/qad.0b013e328340a239 · Cited by 276
Cited by
International AIDS Society global scientific strategy: towards an HIV cure 2016
International AIDS Society Towards a Cure Working Group, Deeks, S. G., Lewin, S. R., Ross, A. L., Ananworanich, J., Benkirane, M., Cannon, P., Chomont, N., Douek, D., Lifson, J. D., et al. (2016) · Nature Medicine · doi:10.1038/nm.4108 · Cited by 425
Self-citationThe RV411 study group, Colby, D. J., Trautmann, L., Pinyakorn, S., Leyre, L., Pagliuzza, A., Kroon, E., Rolland, M., Takata, H., Buranapraditkun, S., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0026-6 · Cited by 331
CD8+ T cells in HIV control, cure and prevention
Collins, D. R., Gaiha, G. D., & Walker, B. D. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-020-0274-9 · Cited by 303
Viral and Immune Risk Factors of HIV Rebound After Interruption of Antiretroviral Therapy
Gianella, S., Yu, T., Wang, R., Ignacio, C., Schanz, M., Kouyos, R. D., Caballero, G., Gaitan, N. C., Rawlings, S., Kuster, H., et al. (2025) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiae585 · Cited by 5
Metadata
- Authors
- Williams, J. P., Hurst, J., Stöhr, W., Robinson, N., Brown, H., Fisher, M., Kinloch, S., Cooper, D., Schechter, M., Tambussi, G., Fidler, S., Carrington, M., Babiker, A., Weber, J., Koelsch, K. K., Kelleher, A. D., Phillips, R. E., Frater, J., & on behalf of the SPARTAC trial investigators
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2014-09-12
- Volume
- 3
- Pages
- e03821-e03821
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2101282227
- Cited by
- 293
- References
- 5
- FWCI
- 14.78
- Type
- journal article
- Language
- en
- Open access
- gold
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- Williams, J. P., Hurst, J., Stöhr, W., Robinson, N., Brown, H., Fisher, M., Kinloch, S., Cooper, D., Schechter, M., Tambussi, G., Fidler, S., Carrington, M., Babiker, A., Weber, J., Koelsch, K. K., Kelleher, A. D., Phillips, R. E., Frater, J., & on behalf of the SPARTAC trial investigators. (2014). HIV-1 DNA predicts disease progression and post-treatment virological control. eLife. https://doi.org/10.7554/elife.03821
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
