Serotonergic neurons signal reward and punishment on multiple timescales

A neural substrate of prediction and reward

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Driving fast-spiking cells induces gamma rhythm and controls sensory responses

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Opponent control of reinforcement by striatal dopamine and serotonin

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An Emerging Technology Framework for the Neurobiology of Appetite

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Functional integration of a serotonergic neuron in the Drosophila antennal lobe

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Risk of punishment influences discrete and coordinated encoding of reward-guided actions by prefrontal cortex and VTA neurons

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Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion

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Implantable Flexible Multielectrode Arrays for Multi-Site Sensing of Serotonin Tonic Levels

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Autism: Oxytocin, serotonin, and social reward

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Interactions between ventrolateral prefrontal and anterior cingulate cortex during learning and behavioural change

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Monoaminergic control of brain states and sensory processing: Existing knowledge and recent insights obtained with optogenetics

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Dorsal raphe serotonin neurons inhibit operant responding for reward via inputs to the ventral tegmental area but not the nucleus accumbens: evidence from studies combining optogenetic stimulation and serotonin reuptake inhibition

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Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment

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Serotonergic regulation of the dopaminergic system: Implications for reward-related functions

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Dopamine and serotonin in human substantia nigra track social context and value signals during economic exchange

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Reward modulates the effect of visual cortical microstimulation on perceptual decisions

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Précis of Vigor: Neuroeconomics of Movement Control

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Cholinergic and dopaminergic effects on prediction error and uncertainty responses during sensory associative learning

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Serotonin's Complex Role in Alcoholism: Implications for Treatment and Future Research

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Activation and inhibition of tph2 serotonergic neurons operate in tandem to influence larval zebrafish preference for light over darkness

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Serotonergic modulation across sensory modalities

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Serotonin and aversive processing in affective and social decision-making

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Organization of dopamine and serotonin system: Anatomical and functional mapping of monosynaptic inputs using rabies virus

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How learning unfolds in the brain: toward an optimization view

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Serotonin's many meanings elude simple theories

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Dorsal Raphe Serotonergic Neurons Control Intertemporal Choice under Trade-off

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Prostaglandin-mediated inhibition of serotonin signaling controls the affective component of inflammatory pain

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Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans

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Brainstem serotonin neurons selectively gate retinal information flow to thalamus

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Acute selective serotonin reuptake inhibitors regulate the dorsal raphe nucleus causing amplification of terminal serotonin release

Dankoski, E. C., Carroll, S., & Wightman, R. M. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13528 · Cited by 39

Information processing in the vertebrate habenula

Fore, S., Palumbo, F., Pelgrims, R., & Yaksi, E. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.08.019 · Cited by 37

The Wiring Logic of an Identified Serotonergic Neuron That Spans Sensory Networks

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Human tau-overexpressing mice recapitulate brainstem involvement and neuropsychiatric features of early Alzheimer’s disease

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Impairment of the serotonergic neurons underlying reinforcement elicits extinction of the repeatedly reactivated context memory

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Reciprocal Lateral Hypothalamic and Raphe GABAergic Projections Promote Wakefulness

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A mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors

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Multiple Mechanisms for Processing Reward Uncertainty in the Primate Basal Forebrain

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Long-Term Impact of Early-Life Stress on Serotonin Connectivity

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Serotonergic Modulation of Olfaction in Rodents and Insects.

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Serotonergic modulation of cognitive computations

Doya, K., Miyazaki, K. W., & Miyazaki, K. (2021) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2021.02.003 · Cited by 30

The “highs and lows” of the human brain on dopaminergics: Evidence from neuropharmacology

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Serotonergic neuromodulation of synaptic plasticity

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A Role for Serotonin in Modulating Opposing Drive and Brake Circuits of Impulsivity

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Opposing Cholinergic and Serotonergic Modulation of Layer 6 in Prefrontal Cortex

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Influence of ovarian hormones on value-based decision-making systems: Contribution to sexual dimorphisms in mental disorders

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The Role of the Lateral Habenula in Inhibitory Learning from Reward Omission

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Neuromodulation and Neurophysiology on the Timescale of Learning and Decision-Making

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The dorsal raphe nucleus in the control of energy balance

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Dopamine and serotonin interplay for valence-based spatial learning

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Nanoscopic Visualization of Restricted Nonvolume Cholinergic and Monoaminergic Transmission with Genetically Encoded Sensors

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Lesions of the lateral habenula facilitate active avoidance learning and threat extinction

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Models of neuromodulation for computational psychiatry

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Sleep disturbances in autism spectrum disorder: Animal models, neural mechanisms, and therapeutics

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Chronic restraint stress induces depression-like behaviors and alterations in the afferent projections of medial prefrontal cortex from multiple brain regions in mice

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Opposing effects of reward and punishment on human vigor

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ON and OFF retinal ganglion cells differentially regulate serotonergic and GABAergic activity in the dorsal raphe nucleus

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Motor thalamus supports striatum-driven reinforcement

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Serotonergic modulation of swallowing in a complete fly vagus nerve connectome

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Nonlinear recurrent inhibition through facilitating serotonin release in the raphe

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Ethological computational psychiatry: Challenges and opportunities

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Impaired value-based decision-making in Parkinson’s disease apathy

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Serotonin regulates dynamics of cerebellar granule cell activity by modulating tonic inhibition

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A prospective code for value in the serotonin system

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Temporal derivative computation in the dorsal raphe network revealed by an experimentally driven augmented integrate-and-fire modeling framework

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Dopaminergic regulation of vocal-motor plasticity and performance

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Disrupted reinforcement learning during post-error slowing in ADHD

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Dorsal raphe nucleus projecting retinal ganglion cells: Why Y cells?

Pickard, G. E., So, K., & Pu, M. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.08.004 · Cited by 21

How do stupendous cannabinoids modulate memory processing via affecting neurotransmitter systems?

Vaseghi, S., Nasehi, M., & Zarrindast, M. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.10.018 · Cited by 21

Stress decreases serotonin tone in the nucleus accumbens in male mice to promote aversion and potentiate cocaine preference via decreased stimulation of 5-HT1B receptors

Fontaine, H. M., Silva, P. R., Neiswanger, C., Tran, R., Abraham, A. D., Land, B. B., Neumaier, J. F., & Chavkin, C. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01178-0 · Cited by 24

Spiking activity in the visual thalamus is coupled to pupil dynamics across temporal scales

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GluA2-Lacking AMPA Receptors and Nitric Oxide Signaling Gate Spike-Timing–Dependent Potentiation of Glutamate Synapses in the Dorsal Raphe Nucleus

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Input-specific contributions to valence processing in the amygdalaPreprint

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Voltage imaging reveals circuit computations in the raphe underlying serotonin-mediated motor vigor learning

Kawashima, T., Wei, Z., Haruvi, R., Shainer, I., Narayan, S., Baier, H., & Ahrens, M. B. (2025) · Neuron · doi:10.1016/j.neuron.2025.05.017 · Cited by 21

Electrophysiological Characteristics of Dorsal Raphe Nucleus in Tail Suspension Test

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Chemical neuromodulation of cognitive control avoidance

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An Elongin-Cullin-SOCS Box Complex Regulates Stress-Induced Serotonergic Neuromodulation

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Reward Modulates Visual Responses in the Superficial Superior Colliculus of Mice

Baruchin, L. J., Alleman, M., & Schröder, S. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0089-23.2023 · Cited by 20

Emotional words evoke region- and valence-specific patterns of concurrent neuromodulator release in human thalamus and cortex

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Reward Timing and Its Expression by Inhibitory Interneurons in the Mouse Primary Visual Cortex

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Modulation of anterior cingulate cortex reward and penalty signalling in medication-naive young-adult subjects with depressive symptoms following acute dose lurasidone

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Tonic activity in lateral habenula neurons acts as a neutral valence brake on reward-seeking behavior

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Direct serotonin release in humans shapes aversive learning and inhibition

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Stereotaxic Adeno-associated Virus Injection and Cannula Implantation in the Dorsal Raphe Nucleus of Mice

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Pallidal circuits for aversive motivation and learning

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Brain-wide, scale-wide physiology underlying behavioral flexibility in zebrafish

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Synthetic surprise as the foundation of the psychedelic experience

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Modulation of serotonin dynamics in the dorsal raphe nucleus via high frequency medial prefrontal cortex stimulation

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An integrated modelling framework for neural circuits with multiple neuromodulators

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Toward a multiscale modeling framework for understanding serotonergic function

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Rhythms, Reward, and Blues: Consequences of Circadian Photoperiod on Affective and Reward Circuit Function

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