Cited by 388Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

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Serotonergic neurons signal reward and punishment on multiple timescales

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Cohen, Jeremiah Y, Amoroso, Mackenzie W, Uchida, Naoshige·2015·eLife

DOI 10.7554/elife.06346PMC PMC4389268

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Abstract

Serotonin's function in the brain is unclear. One challenge in testing the numerous hypotheses about serotonin's function has been observing the activity of identified serotonergic neurons in animals engaged in behavioral tasks. We recorded the activity of dorsal raphe neurons while mice experienced a task in which rewards and punishments varied across blocks of trials. We 'tagged' serotonergic neurons with the light-sensitive protein channelrhodopsin-2 and identified them based on their responses to light. We found three main features of serotonergic neuron activity: (1) a large fraction of serotonergic neurons modulated their tonic firing rates over the course of minutes during reward vs punishment blocks; (2) most were phasically excited by punishments; and (3) a subset was phasically excited by reward-predicting cues. By contrast, dopaminergic neurons did not show firing rate changes across blocks of trials. These results suggest that serotonergic neurons signal information about reward and punishment on multiple timescales.

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Authors: Cohen, J. Y., Amoroso, M. W., & Uchida, N.
Affiliations: Harvard University (US)
Corresponding author: Cohen, Jeremiah Y
ORCID: Cohen, Jeremiah Y
Amoroso, Mackenzie W
Uchida, Naoshige
Venue: eLife
Publisher: eLife Sciences Publications, Ltd
Published: 2015-02-25
Volume: 4
ISSN: 2050-084X (ISSN-L)
DOI: 10.7554/elife.06346
PMC: PMC4389268
OpenAlex: W2127567317
Cited by: 388
References: 123
Citations by year: 2026: 23 · 2025: 39 · 2024: 38 · 2023: 32 · 2022: 23 · 2021: 37 · 2020: 31 · 2019: 33 · 2018: 30 · 2017: 40 · 2016: 44 · 2015: 18
FWCI: 20.43
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
creativecommons.org/licenses/by/4.0/ (am)
creativecommons.org/licenses/by/4.0/ (tdm)
Locations: eLife (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders: Helen Hay Whitney Foundation (HHWF) (HHMI Fellowship from the HHWF)
Howard Hughes Medical Institute (HHMI) (HHMI Fellowship from the HHWF)
National Science Foundation (NSF) (Graduate Research Fellowship)
National Institutes of Health (NIH) (R01MH095953, R01MH101207)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: serotonin, serotonergic neurons, dorsal raphe nucleus, reward, punishment, dopamine, channelrhodopsin-2, reward prediction, mice
MeSH terms: Action Potentials, Animals, Behavior, Animal, Conditioning, Psychological, Cues, Mice, Inbred C57BL, Neural Inhibition, Punishment, Reward, Serotonin, Task Performance and Analysis, Time Factors, Serotonergic Neurons

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Serotonergic neurons signal reward and punishment on multiple timescales

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