Long-Term Impact of Early-Life Stress on Serotonin Connectivity

Effects of stress throughout the lifespan on the brain, behaviour and cognition

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Risky families: Family social environments and the mental and physical health of offspring

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Adverse childhood experiences and the risk of depressive disorders in adulthood

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The Neurocircuitry of Fear, Stress, and Anxiety Disorders

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The neurobiological consequences of early stress and childhood maltreatment

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Diagnosis and definition of treatment-resistant depression

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Effects of early life stress on cognitive and affective function: an integrated review of human literature

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The developmental role of serotonin: news from mouse molecular genetics

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5-HT and mechanisms of defence

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Early Life Programming and Neurodevelopmental Disorders

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Early-Life Blockade of the 5-HT Transporter Alters Emotional Behavior in Adult Mice

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The Role of Early Life Stress in Adult Psychiatric Disorders: A Systematic Review According to Childhood Trauma Subtypes

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Paradise lost: the neurobiological and clinical consequences of child abuse and neglect

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Serotonin and brain function: a tale of two receptors

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Regional cerebral blood flow during script-driven imagery in childhood sexual abuse-related PTSD: A PET investigation

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Future Directions in Childhood Adversity and Youth Psychopathology

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Early Adverse Experiences and the Developing Brain

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Anatomically defined and functionally distinct dorsal raphe serotonin sub-systems

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Toward understanding how early-life stress reprograms cognitive and emotional brain networks

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Dorsal raphe neurons signal reward through 5-HT and glutamate

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Early stress is associated with alterations in the orbitofrontal cortex: a tensor-based morphometry investigation of brain structure and behavioral risk

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Alterations in default network connectivity in posttraumatic stress disorder related to early-life trauma

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Serotonin neurons in the dorsal raphe nucleus encode reward signals

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Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential

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Serotonergic neurons signal reward and punishment on multiple timescales

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Reduced resting-state functional connectivity between amygdala and orbitofrontal cortex in social anxiety disorder

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Serotonin and brain development

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Embracing diversity in the 5-HT neuronal system

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The Role of the Orbitofrontal Cortex in Anxiety Disorders

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Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei

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Conditional anterograde tracing reveals distinct targeting of individual serotonin cell groups (B5-B9) to the forebrain and brainstem

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Longitudinal associations among child maltreatment, social functioning, and cortisol regulation.

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The Intergenerational Transmission of Anxiety: A Children-of-Twins Study

Eley, T. C., McAdams, T. A., Rijsdijk, F. V., Lichtenstein, P., Narusyte, J., Reiss, D., Spotts, E. L., Ganiban, J. M., & Neiderhiser, J. M. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.14070818 · Cited by 255 · see citing works

A Hypothesis of Gender Differences in Self-Reporting Symptom of Depression: Implications to Solve Under-Diagnosis and Under-Treatment of Depression in Males

Shi, P., Yang, A., Zhao, Q., Chen, Z., Ren, X.-M., & Dai, Q. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.589687 · Cited by 248 · see citing works

Early life stress and brain function: Activity and connectivity associated with processing emotion and reward

Herzberg, M. P., & Gunnar, M. R. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.116493 · Cited by 238 · see citing works

Overlapping and segregated resting‐state functional connectivity in patients with major depressive disorder with and without childhood neglect

Wang, L., Dai, Z., Peng, H., Tan, L., Ding, Y., He, Z., Zhang, Y., Xia, M., Li, Z., Li, W., et al. (2014) · Human Brain Mapping · doi:10.1002/hbm.22241 · Cited by 236 · see citing works

Differential functional connectivity within an emotion regulation neural network among individuals resilient and susceptible to the depressogenic effects of early life stress

Cisler, J. M., James, G. A., Tripathi, S., Mletzko, T., Heim, C., Hu, X. P., Mayberg, H. S., Nemeroff, C. B., & Kilts, C. D. (2013) · Psychological Medicine · doi:10.1017/s0033291712001390 · Cited by 236 · see citing works

A genetic approach to access serotonin neurons for in vivo and in vitro studies

Scott, M. M., Wylie, C. J., Lerch, J. K., Murphy, R., Lobur, K. J., Herlitze, S., Jiang, W., Conlon, R. A., Strowbridge, B. W., & Deneris, E. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504510102 · Cited by 233 · see citing works

Risky families: Family social environments and the mental and physical health of offspring.

Repetti, R. L., Taylor, S. E., & Seeman, T. E. (2002) · Psychological Bulletin · doi:10.1037/0033-2909.128.2.230 · Cited by 225 · see citing works

Serotonin and stress coping

Puglisi‐Allegra, S., & Andolina, D. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.052 · Cited by 203 · see citing works

Alterations in amygdala–prefrontal circuits in infants exposed to prenatal maternal depression

Posner, J., Cha, J., Roy, A. K., Peterson, B. S., Bansal, R., Gustafsson, H. C., Raffanello, E., Gingrich, J., & Monk, C. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.146 · Cited by 184 · see citing works

Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning

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Role of Orbitofrontal Cortex Connections in Emotion

Rempel-Clower, N. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.026 · Cited by 181 · see citing works

Early life adversity shapes neural circuit function during sensitive postnatal developmental periods

Malave, L., van Dijk, M. T., & Anacker, C. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02092-9 · Cited by 177 · see citing works

Transient Firing of Dorsal Raphe Neurons Encodes Diverse and Specific Sensory, Motor, and Reward Events

Ranade, S., & Mainen, Z. F. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00507.2009 · Cited by 174 · see citing works

Maternal licking regulates hippocampal glucocorticoid receptor transcription through a thyroid hormone–serotonin–NGFI-A signalling cascade

Hellstrom, I. C., Dhir, S. K., Diorio, J. C., & Meaney, M. J. (2012) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2012.0223 · Cited by 171 · see citing works

Functional MRI changes during panic anticipation and imagery exposure

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The role of serotonin in the regulation of patience and impulsivity

Miyazaki, K., Miyazaki, K. W., & Doya, K. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8232-6 · Cited by 162 · see citing works

Dopamine and serotonin signaling during two sensitive developmental periods differentially impact adult aggressive and affective behaviors in mice

Yu, Q., Teixeira, C. M., Mahadevia, D., Huang, Y., Balsam, D., Mann, J. J., Gingrich, J. A., & Ansorge, M. S. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.10 · Cited by 157 · see citing works

Early Life Stress, Mood, and Anxiety Disorders

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Disrupted effective connectivity between the amygdala and orbitofrontal cortex in social anxiety disorder during emotion discrimination revealed by dynamic causal modeling for fMRI

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Intense threat switches dorsal raphe serotonin neurons to a paradoxical operational mode

Seo, C., Guru, A., Jin, M., Ito, B. S., Sleezer, B. J., Ho, Y.-Y., Wang, E., Boada, C. M., Krupa, N. A., Kullakanda, D. S., et al. (2019) · Science · doi:10.1126/science.aau8722 · Cited by 146 · see citing works

Both long and brief maternal separation produces persistent changes in tissue levels of brain monoamines in middle-aged female rats

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Role of the Primate Orbitofrontal Cortex in Mediating Anxious Temperament

Kalin, N. H., Shelton, S. E., & Davidson, R. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.04.004 · Cited by 135 · see citing works

Maternal Absence and Stability of Individual Differences in CSF 5-HIAA Concentrations in Rhesus Monkey Infants

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Single-cell activity and network properties of dorsal raphe nucleus serotonin neurons during emotionally salient behaviors

Paquelet, G. E., Carrion, K., Lacefield, C., Zhou, P., Hen, R., & Miller, B. R. (2022) · Neuron · doi:10.1016/j.neuron.2022.05.015 · Cited by 129 · see citing works

Childhood trauma and cognitive function in first-episode affective and non-affective psychosis

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Expression mapping of 5-HT1 serotonin receptor subtypes during fetal and early postnatal mouse forebrain development

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Sex Differences in the Regulation of Serotonergic Transmission and Behavior in 5-HT Receptor Knockout Mice

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Neuroimaging and the Neuroanatomy of Posttraumatic Stress Disorder

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Early Social Adversity, Altered Brain Functional Connectivity, and Mental Health

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Influence of parenting style on the offspring's behaviour and CSF monoamine metabolite levels in crossfostered and noncrossfostered female rhesus macaques

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Decreased default network connectivity is associated with early life stress in medication-free healthy adults

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Enhanced Function of Prefrontal Serotonin 5-HT 2 Receptors in a Rat Model of Psychiatric Vulnerability

Benekareddy, M., Goodfellow, N. M., Lambe, E. K., & Vaidya, V. A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3245-10.2010 · Cited by 100 · see citing works

The Long-Term Impact of Early Life Poverty on Orbitofrontal Cortex Volume in Adulthood: Results from a Prospective Study Over 25 Years

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Limited Bedding and Nesting Induces Maternal Behavior Resembling Both Hypervigilance and Abuse

Gallo, M. E., Shleifer, D. G., Godoy, L. D., Ofray, D., Olaniyan, A., Campbell, T., & Bath, K. G. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00167 · Cited by 93 · see citing works

Default mode alterations in posttraumatic stress disorder related to early-life trauma: a developmental perspective

Daniels, J. (2011) · Journal of Psychiatry & Neuroscience · doi:10.1503/jpn.100050 · Cited by 93 · see citing works

Manipulation of dorsal raphe serotonergic neurons modulates active coping to inescapable stress and anxiety-related behaviors in mice and rats

Nishitani, N., Nagayasu, K., Asaoka, N., Yamashiro, M., Andoh, C., Nagai, Y., Kinoshita, H., Kawai, H., Shibui, N., Liu, B., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0254-y · Cited by 92 · see citing works

The Importance of Serotonin for Orbitofrontal Function

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Early-life stress induces persistent alterations in 5-HT1A receptor and serotonin transporter mRNA expression in the adult rat brain

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Early Childhood Parenting Predicts Late Childhood Brain Functional Connectivity During Emotion Perception and Reward Processing

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Altered ventral striatal–medial prefrontal cortex resting-state connectivity mediates adolescent social problems after early institutional care

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Abnormal Serotonin Levels During Perinatal Development Lead to Behavioral Deficits in Adulthood

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Regional cerebral metabolic asymmetries replicated in an independent group of patients with panic disorder

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The role of serotonin in reward, punishment and behavioural inhibition in humans: Insights from studies with acute tryptophan depletion

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Markers of Serotonergic Function in the Orbitofrontal Cortex and Dorsal Raphé Nucleus Predict Individual Variation in Spatial-Discrimination Serial Reversal Learning

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Prefrontal/Amygdalar System Determines Stress Coping Behavior Through 5-HT/GABA Connection

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Early life stress delays hippocampal development and diminishes the adult stem cell pool in mice

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The Effect of Early Life Stress on Adult Psychiatric Disorders.

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Primate Orbitofrontal Cortex Codes Information Relevant for Managing Explore–Exploit Tradeoffs

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Serotonergic projections to the orbitofrontal and medial prefrontal cortices differentially modulate waiting for future rewards

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Serotonin regulation of the prefrontal cortex: cognitive relevance and the impact of developmental perturbation

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Abnormal Prefrontal Development in Pediatric Posttraumatic Stress Disorder: A Longitudinal Structural and Functional Magnetic Resonance Imaging Study

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Enduring good memories of infant trauma: Rescue of adult neurobehavioral deficits via amygdala serotonin and corticosterone interaction

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Transient postnatal elevation of serotonin levels in mouse neocortex

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Single-Cell Transcriptional Changes in Hypothalamic Corticotropin-Releasing Factor–Expressing Neurons After Early-Life Adversity Inform Enduring Alterations in Vulnerabilities to Stress

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Reactivation of Early-Life Stress-Sensitive Neuronal Ensembles Contributes to Lifelong Stress Hypersensitivity

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The Long-Term Impact of Early Life Stress on Orbitofrontal Cortical Thickness

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Directed Evolution of a Selective and Sensitive Serotonin Biosensor Via Machine LearningPreprint

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Serotonin-related rodent models of early-life exposure relevant for neurodevelopmental vulnerability to psychiatric disorders

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Reviewer #1 (Public Review): Early-life stress induces persistent astrocyte dysfunction resulting in fear generalisation

(2024) · eLife · doi:10.7554/elife.99988.1.sa2

Reviewer #2 (Public Review): Early-life stress induces persistent astrocyte dysfunction resulting in fear generalisation

(2024) · eLife · doi:10.7554/elife.99988.1.sa1

Reviewer #3 (Public Review): Early-life stress induces persistent astrocyte dysfunction resulting in fear generalisation

(2024) · eLife · doi:10.7554/elife.99988.1.sa0

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