Spatial tuning and brain state account for dorsal hippocampal CA1 activity in a non-spatial learning task
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The hippocampus is a brain area crucial for episodic memory in humans. In contrast, studies in rodents have highlighted its role in spatial learning, supported by the discovery of place cells. Efforts to reconcile these views have found neurons in the rodent hippocampus that respond to non-spatial events but have not unequivocally dissociated the spatial and non-spatial influences on these cells. To disentangle these influences, we trained freely moving rats in trace eyeblink conditioning, a hippocampally dependent task in which the animal learns to blink in response to a tone. We show that dorsal CA1 pyramidal neurons are all place cells, and do not respond to the tone when the animal is moving. When the animal is inactive, the apparent tone-evoked responses reflect an arousal-mediated resumption of place-specific firing. These results suggest that one of the main output stages of the hippocampus transmits only spatial information, even in this non-spatial task.
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Changes in arousal modulate the membrane potential of hippocampal pyramidal neurons and hippocampal dynamics, and are gated by spatial location.
“Our findings are in line with previous work, which showed that changes in arousal modulate the membrane potential of hippocampal pyramidal neurons75 and hippocampal dynamics75–78, and are gated by spatial location77.”
From Place and behavioral modulation of hippocampal neurons during immobility (2026) · cites this paper as [77]
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- Authors
- Shan, K. Q., Lubenov, E. V., Papadopoulou, M., & Siapas, A. G.
- Affiliations
- California Institute of Technology (US)
- Corresponding author
- Siapas, Athanassios G
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2016-08-03
- Volume
- 5
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC4972538
- OpenAlex
- W2480782216
- Cited by
- 27
- References
- 37
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 1 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 4
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Larry L. Hillblom Foundation
- National Science Foundation (IOS-1146871)
- National Institutes of Health (1DP1OD008255, 5DP1MH099907)
- G Harold and Leila Y. Mathers Foundation
- Gordon and Betty Moore Foundation
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- dorsal hippocampus, CA1 pyramidal neurons, place cells, trace eyeblink conditioning, spatial tuning, brain states, arousal, hippocampal output, episodic memory
- MeSH terms
- Animals, Blinking, Learning, Locomotion, Pyramidal Cells, Rats, CA1 Region, Hippocampal
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