Hippocampal Place Cells Acquire Location-Specific Responses to the Conditioned Stimulus during Auditory Fear Conditioning
Open accessAbstract
We recorded neurons from the hippocampus of freely behaving rats during an auditory fear conditioning task. Rats received either paired or unpaired presentations of an auditory conditioned stimulus (CS) and an electric shock unconditioned stimulus (US). Hippocampal neurons (place and theta cells) acquired responses to the auditory CS in the paired but not in the unpaired group. After CS-US pairing, rhythmic firing of theta cells became synchronized to the onset of the CS. Conditioned responses of place cells were gated by their location-specific firing, so that after CS-US pairing, place cells responded to the CS only when the rat was within the cell's place field. These findings may help to elucidate how the hippocampus contributes to context-specific memory formation during associative learning.
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Changes in arousal modulate the membrane potential of hippocampal pyramidal neurons and hippocampal dynamics, and are gated by spatial location.
“Our findings are in line with previous work, which showed that changes in arousal modulate the membrane potential of hippocampal pyramidal neurons75 and hippocampal dynamics75–78, and are gated by spatial location77.”
From Place and behavioral modulation of hippocampal neurons during immobility (2026) · cites this paper as [78]
Hippocampal cells exhibit plasticity of their place fields in response to contextual fear conditioning.
“Moreover, hippocampal cells exhibit plasticity of their place fields in response to contextual fear conditioning (Moita et al. [185]; Moita et al. [186])”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Moita et al. [185]
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- Authors
- Moita, M. A. P., Rosis, S., Zhou, Y., LeDoux, J. E., & Blair, H. T.
- Affiliations
- Cold Spring Harbor Laboratory (US)
- New York University (US)
- University of California, Los Angeles (US)
- Corresponding author
- Blair, Hugh T.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 37
- Issue
- 3
- Pages
- 485-497
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2056752966
- Cited by
- 295
- References
- 71
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 25 · 2023: 11 · 2022: 12 · 2021: 12 · 2020: 11 · 2019: 7 · 2018: 10 · 2017: 10 · 2016: 11 · 2015: 12 · 2014: 13 · 2013: 9 · 2012: 21
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Funders
- National Institutes of Health (5k02mh000956-07)
- National Institute of Mental Health (MH12341, MH 46516, MH 00956, F32MH012341, R01MH046516, MH38774)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- place cells, auditory fear conditioning, conditioned stimulus, CS-US pairing, place fields, associative learning, hippocampal neurons
- MeSH terms
- Acoustic Stimulation, Animals, Association Learning, Behavior, Animal, Conditioning, Psychological, Electrophysiology, Electroshock, Fear, Hippocampus, Male, Movement, Space Perception, Theta Rhythm, Rats, Sprague-Dawley, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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