The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1
Open accessAbstract
A defining feature of mitochondria is their maternal mode of inheritance. However, little is understood about the cellular mechanism through which paternal mitochondria, delivered from sperm, are eliminated from early mammalian embryos. Autophagy has been implicated in nematodes, but whether this mechanism is conserved in mammals has been disputed. Here, we show that cultured mouse fibroblasts and pre-implantation embryos use a common pathway for elimination of mitochondria. Both situations utilize mitophagy, in which mitochondria are sequestered by autophagosomes and delivered to lysosomes for degradation. The E3 ubiquitin ligases PARKIN and MUL1 play redundant roles in elimination of paternal mitochondria. The process is associated with depolarization of paternal mitochondria and additionally requires the mitochondrial outer membrane protein FIS1, the autophagy adaptor P62, and PINK1 kinase. Our results indicate that strict maternal transmission of mitochondria relies on mitophagy and uncover a collaboration between MUL1 and PARKIN in this process.
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1 retracted
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RetractedRepertoires of Autophagy in the Pathogenesis of Ocular Diseases
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“In addition, we found that p62 (SQSTM1), a protein implicated in autophagy (Pankiv et al., 2007) and mitophagy (Seibenhener et al.”
BackgroundParkin is recruited selectively to impaired mitochondria and promotes their autophagy
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PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
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Cited by
Biological Functions of Autophagy Genes: A Disease Perspective
Levine, B., & Kroemer, G. (2019) · Cell · doi:10.1016/j.cell.2018.09.048 · Cited by 2,832
Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance
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Molecular definitions of autophagy and related processes
Galluzzi, L., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo‐San Pedro, J. M., Cecconi, F., Choi, A. M., Chu, C. T., Codogno, P., Colombo, M. I., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201796697 · Cited by 1,646
Mitochondrial Dynamics and Its Involvement in Disease
Chan, D. C. (2020) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012419-032711 · Cited by 1,416
Self-citationCombination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer
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Metadata
- Authors
- Rojansky, R., Cha, M.-Y., & Chan, D. C.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2016-11-17
- Volume
- 5
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2551880155
- Cited by
- 336
- References
- 49
- FWCI
- 27.53
- Type
- journal article
- Language
- en
- Open access
- gold
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- Rojansky, R., Cha, M.-Y., & Chan, D. C. (2016). Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1. eLife. https://doi.org/10.7554/elife.17896
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