Cited by 151Neuroendocrine regulation and behaviorOlfactory and Sensory Function StudiesHypothalamic control of reproductive hormones

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Oxytocin signaling in the medial amygdala is required for sex discrimination of social cues

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Yao, Shenqin, Bergan, Joseph, Lanjuin, Anne, Dulac, Catherine·2017·eLife

DOI 10.7554/elife.31373PMC PMC5768418

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Abstract

The neural control of social behaviors in rodents requires the encoding of pheromonal cues by the vomeronasal system. Here we show that the typical preference of male mice for females is eliminated in mutants lacking oxytocin, a neuropeptide modulating social behaviors in many species. Ablation of the oxytocin receptor in aromatase-expressing neurons of the medial amygdala (MeA) fully recapitulates the elimination of female preference in males. Further, single-unit recording in the MeA uncovered significant changes in the sensory representation of conspecific cues in the absence of oxytocin signaling. Finally, acute manipulation of oxytocin signaling in adults is sufficient to alter social interaction preferences in males as well as responses of MeA neurons to chemosensory cues. These results uncover the critical role of oxytocin signaling in a molecularly defined neuronal population in order to modulate the behavioral and physiological responses of male mice to females on a moment-to-moment basis.

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Authors: Yao, S., Bergan, J., Lanjuin, A., & Dulac, C.
Affiliations: Allen Institute for Brain Science (US)
Howard Hughes Medical Institute (US)
Corresponding author: Dulac, Catherine
ORCID: Yao, Shenqin
Bergan, Joseph
Lanjuin, Anne
Dulac, Catherine
Venue: eLife
Publisher: eLife Sciences Publications, Ltd
Published: 2017-12-12
Volume: 6
ISSN: 2050-084X (ISSN-L)
DOI: 10.7554/elife.31373
PMC: PMC5768418
OpenAlex: W2746264266
Cited by: 151
References: 108
Citations by year: 2026: 13 · 2025: 18 · 2024: 15 · 2023: 16 · 2022: 19 · 2021: 27 · 2020: 17 · 2019: 10 · 2018: 15 · 2017: 1
FWCI: 16.83
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
creativecommons.org/licenses/by/4.0/ (am)
creativecommons.org/licenses/by/4.0/ (tdm)
Locations: eLife (publishedVersion, cc-by)
bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institute on Deafness and Other Communication Disorders (R01DC013087)
Simons Foundation (Simons Foundation Autism Research Initiative - 308094)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: oxytocin signaling, medial amygdala, gender discrimination, social behavior, vomeronasal system, oxytocin receptor, female preference, social interaction, mice
MeSH terms: Amygdala, Animals, Cells, Cultured, Cues, Discrimination, Psychological, Female, Male, Mice, Inbred C57BL, Oxytocics, Oxytocin, Sensory Receptor Cells, Sexual Behavior, Animal, Social Behavior, Receptors, Oxytocin, Mice, Knockout, Mice

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Oxytocin signaling in the medial amygdala is required for sex discrimination of social cues

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