An amygdala-to-hypothalamus circuit for social reward
Open accessAbstract
Social interactions and relationships are often rewarding, but the neural mechanisms through which social interaction drives positive experience remain poorly understood. In this study, we developed an automated operant conditioning system to measure social reward in mice and found that adult mice of both sexes display robust reinforcement of social interaction. Through cell-type-specific manipulations, we identified a crucial role for GABAergic neurons in the medial amygdala (MeA) in promoting the positive reinforcement of social interaction. Moreover, MeA GABAergic neurons mediate social reinforcement behavior through their projections to the medial preoptic area (MPOA) and promote dopamine release in the nucleus accumbens. Finally, activation of this MeA-to-MPOA circuit can robustly overcome avoidance behavior. Together, these findings establish the MeA as a key node for regulating social reward in both sexes, providing new insights into the regulation of social reward beyond the classic mesolimbic reward system.
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The increase in VTA dopamine activity appears in part to be driven by the activity of GABAergic neurons in the medial amygdala, via their projections to the medial preoptic nucleus that in turn directly connects to the VTA.
“This increase in VTA DA activity appears in part to be driven by the activity of GABAergic neurons in the medial amygdala, via their projections to the medial preoptic nucleus that in turn directly connects to the VTA [58].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [58]
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- [40]Prévost-Solié C, Girard B, Righetti B, Tapparel M & Bellone C Dopamine neurons of the VTA encode active conspecific interaction and promote social learning through social reward prediction error. Biorxiv 2020.05.27.118851 (2020) doi: 10.1101/2020.05.27.118851. · DOI
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- Authors
- Hu, R. K., Zuo, Y., Ly, T., Wang, J., Meera, P., Wu, Y. E., & Hong, W.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Hong, Weizhe
- Venue
- Nature Neuroscience
- Published
- 2021-04-05
- Volume
- 24
- Issue
- 6
- Pages
- 831-842
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC8236486
- OpenAlex
- W3148247179
- Cited by
- 174
- References
- 56
- Citations by year
- 2026: 21 · 2025: 35 · 2024: 47 · 2023: 32 · 2022: 29 · 2021: 9 · 2019: 1
- FWCI
- 13.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- UC | UCLA | David Geffen School of Medicine, University of California, Los Angeles (Marion Bowen Postdoctoral Grant)
- U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS113124)
- Kinship Foundation (Searle Scholars Award)
- Esther A. and Joseph Klingenstein Fund (Klingenstein-Simons Fellowship)
- David and Lucile Packard Foundation (Fellowship)
- McKnight Endowment Fund for Neuroscience (Scholar Award)
- W. M. Keck Foundation (Junior Faculty Award)
- Vallee Foundation (N/A)
- Edward Mallinckrodt, Jr. Foundation (N/A)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- social reward, medial amygdala, medial preoptic area, hypothalamus, GABAergic neurons, dopamine release, nucleus accumbens, social reinforcement, avoidance behavior, sex differences, mesolimbic reward system
- MeSH terms
- Amygdala, Animals, Conditioning, Operant, Female, Hypothalamus, Male, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Reinforcement, Psychology, Reward, Social Behavior, Mice, Optogenetics
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