The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation
Open accessAbstract
Upon antigen stimulation, T lymphocytes undergo dramatic changes in metabolism to fulfill the bioenergetic, biosynthetic and redox demands of proliferation and differentiation. Glutathione (GSH) plays an essential role in controlling redox balance and cell fate. While GSH can be recycled from Glutathione disulfide (GSSG), the inhibition of this recycling pathway does not impact GSH content and murine T cell fate. By contrast, the inhibition of the de novo synthesis of GSH, by deleting either the catalytic (Gclc) or the modifier (Gclm) subunit of glutamate–cysteine ligase (Gcl), dampens intracellular GSH, increases ROS, and impact T cell differentiation. Moreover, the inhibition of GSH de novo synthesis dampened the pathological progression of experimental autoimmune encephalomyelitis (EAE). We further reveal that glutamine provides essential precursors for GSH biosynthesis. Our findings suggest that glutamine catabolism fuels de novo synthesis of GSH and directs the lineage choice in T cells.
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Metadata
- Authors
- Lian, G., Gnanaprakasam, J. R., Wang, T., Wu, R., Chen, X., Liu, L., Shen, Y., Yang, M., Yang, J., Chen, Y., Vasiliou, V., Cassel, T. A., Green, D. R., Liu, Y., Fan, T. W., & Wang, R.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2018-09-10
- Volume
- 7
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2892039303
- Cited by
- 196
- References
- 33
- FWCI
- 6.04
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lian, G., Gnanaprakasam, J. R., Wang, T., Wu, R., Chen, X., Liu, L., Shen, Y., Yang, M., Yang, J., Chen, Y., Vasiliou, V., Cassel, T. A., Green, D. R., Liu, Y., Fan, T. W., & Wang, R. (2018). Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation. eLife. https://doi.org/10.7554/elife.36158
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