Cited by 596Gut microbiota and healthOral microbiology and periodontitis researchMicrobial Community Ecology and Physiology

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Extensive transmission of microbes along the gastrointestinal tract

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Schmidt, Thomas SB, Hayward, Matthew R, Coelho, Luis P, Li, Simone S, Costea, Paul I, Voigt, Anita Y, Wirbel, Jakob, Maistrenko, Oleksandr M, Alves, Renato JC, Bergsten, Emma, de Beaufort, Carine, Sobhani, Iradj, Heintz-Buschart, Anna, Sunagawa, Shinichi, Zeller, Georg, Wilmes, Paul, Bork, Peer·2019·eLife

DOI 10.7554/elife.42693PMC PMC6424576

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Abstract

The gastrointestinal tract is abundantly colonized by microbes, yet the translocation of oral species to the intestine is considered a rare aberrant event, and a hallmark of disease. By studying salivary and fecal microbial strain populations of 310 species in 470 individuals from five countries, we found that transmission to, and subsequent colonization of, the large intestine by oral microbes is common and extensive among healthy individuals. We found evidence for a vast majority of oral species to be transferable, with increased levels of transmission in colorectal cancer and rheumatoid arthritis patients and, more generally, for species described as opportunistic pathogens. This establishes the oral cavity as an endogenous reservoir for gut microbial strains, and oral-fecal transmission as an important process that shapes the gastrointestinal microbiome in health and disease.

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Authors: Schmidt, T. S., Hayward, M. R., Coelho, L. P., Li, S. S., Costea, P. I., Voigt, A. Y., Wirbel, J., Maistrenko, O. M., Alves, R. J., Bergsten, E., de Beaufort, C., Sobhani, I., Heintz-Buschart, A., Sunagawa, S., Zeller, G., Wilmes, P., & Bork, P.
Affiliations: European Molecular Biology Laboratory (DE)
Ragon Institute of MGH, MIT and Harvard (US)
Fudan University (CN)
Novo Nordisk Foundation (DK)
Heidelberg University (DE)
Université Paris-Est Créteil (FR)
Luxembourg Centre for Systems Biomedicine, Luxembourg, Luxembourg
ETH Zurich (CH)
Luxembourg Centre for Systems Biomedicine (LU)
Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
ORCID: Schmidt, Thomas SB
Hayward, Matthew R
Coelho, Luis P
Li, Simone S
Costea, Paul I
Voigt, Anita Y
Wirbel, Jakob
Maistrenko, Oleksandr M
Alves, Renato JC
Bergsten, Emma
de Beaufort, Carine
Sobhani, Iradj
Heintz-Buschart, Anna
Sunagawa, Shinichi
Zeller, Georg
Wilmes, Paul
Bork, Peer
Venue: eLife
Publisher: eLife Sciences Publications, Ltd
Published: 2019-02-12
Volume: 8
ISSN: 2050-084X (ISSN-L)
DOI: 10.7554/elife.42693
PMC: PMC6424576
OpenAlex: W2950245396
Cited by: 596
References: 51
Citations by year: 2026: 96 · 2025: 78 · 2024: 120 · 2023: 80 · 2022: 91 · 2021: 80 · 2020: 37 · 2019: 14
FWCI: 18.27
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
creativecommons.org/licenses/by/4.0/ (am)
creativecommons.org/licenses/by/4.0/ (tdm)
Locations: eLife (publishedVersion, cc-by)
bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (acceptedVersion)
Open Repository and Bibliography (University of Luxembourg) (submittedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Online Publication Service of Würzburg University (Würzburg University) (submittedVersion, cc-by)
Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by)
ETH Zürich Research Collection (cc-by)
Funders: Fonds National de la Recherche Luxembourg (CORE/15/BM/10404093)
H2020 European Research Council (ERC-AdG-669830)
H2020 Marie Skłodowska-Curie Actions (661019)
German Network for Bioinformatics Infrastructure (de.NBI #031A537B)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
Keywords: fecal-oral transmission, oral microbiota, gut microbiota, microbial colonization, large intestine, opportunistic pathogens, colorectal cancer, rheumatoid arthritis, salivary microbiota, fecal microbiota
MeSH terms: Bacteria, Feces, Humans, Intestine, Large, Mouth, Saliva, Cluster Analysis, Metagenomics, Microbiota

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