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A role for CIM6P/IGF2 receptor in memory consolidation and enhancement

Yu, Xiao-Wen, Pandey, Kiran, Katzman, Aaron C, Alberini, Cristina M·2020·eLife
DOI 10.7554/elife.54781PMC PMC7200152
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Abstract

Cation-independent mannose-6-phosphate receptor, also called insulin-like growth factor two receptor (CIM6P/IGF2R), plays important roles in growth and development, but is also extensively expressed in the mature nervous system, particularly in the hippocampus, where its functions are largely unknown. One of its major ligands, IGF2, is critical for long-term memory formation and strengthening. Using CIM6P/IGF2R inhibition in rats and neuron-specific knockdown in mice, here we show that hippocampal CIM6P/IGF2R is necessary for hippocampus-dependent memory consolidation, but dispensable for learning, memory retrieval, and reconsolidation. CIM6P/IGF2R controls the training-induced upregulation of de novo protein synthesis, including increase of Arc, Egr1, and c-Fos proteins, without affecting their mRNA induction. Hippocampal or systemic administration of mannose-6-phosphate, like IGF2, significantly enhances memory retention and persistence in a CIM6P/IGF2R-dependent manner. Thus, hippocampal CIM6P/IGF2R plays a critical role in memory consolidation by controlling the rate of training-regulated protein metabolism and is also a target mechanism for memory enhancement.

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Metadata

Authors
Yu, X.-W., Pandey, K., Katzman, A. C., & Alberini, C. M.
Affiliations
Center for Neural Science, New York University, New York, United States
ORCID
Venue
eLife
Publisher
eLife Sciences Publications, Ltd
Published
2020-05-05
Volume
9
ISSN
2050-084X
DOI
10.7554/elife.54781
PMC
PMC7200152
Cited by
40
References
3
Language
en
Licence
Funders
National Institute of Mental Health (MH065635)

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