PreprintCited by 362Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchMemory Processes and Influences

The Regulation of Transcription in Memory Consolidation

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Alberini, Cristina M., Kandel, Eric R.·2015·Cold Spring Harbor Perspectives in Biology

Abstract

De novo transcription of DNA is a fundamental requirement for the formation of long-term memory. It is required during both consolidation and reconsolidation, the posttraining and postreactivation phases that change the state of the memory from a fragile into a stable and long-lasting form. Transcription generates both mRNAs that are translated into proteins, which are necessary for the growth of new synaptic connections, as well as noncoding RNA transcripts that have regulatory or effector roles in gene expression. The result is a cascade of events that ultimately leads to structural changes in the neurons that mediate long-term memory storage. The de novo transcription, critical for synaptic plasticity and memory formation, is orchestrated by chromatin and epigenetic modifications. The complexity of transcription regulation, its temporal progression, and the effectors produced all contribute to the flexibility and persistence of long-term memory formation. In this article, we provide an overview of the mechanisms contributing to this transcriptional regulation underlying long-term memory formation.

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  1. Agranoff BW. 1967. Agents that block memory. In The neu- rosciences: A study program. Rockefeller University Press, New York.

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Authors
Alberini, C. M., & Kandel, E. R.
Affiliations
  • New York University (US)
  • Howard Hughes Medical Institute (US)
Venue
Cold Spring Harbor Perspectives in Biology
Published
2014-12-04
Volume
7
Issue
1
Pages
a021741
ISSN
1943-0264 (ISSN-L)
OpenAlex
W2024465869
Cited by
362
References
137
Citations by year
2026: 10 · 2025: 25 · 2024: 56 · 2023: 42 · 2022: 32 · 2021: 38 · 2020: 40 · 2019: 29 · 2018: 31 · 2017: 24 · 2016: 25 · 2015: 10
Type
posted content
Language
en
Open access
Locations
  • Cold Spring Harbor Perspectives in Biology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Howard Hughes Medical Institute
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
transcriptional regulation, memory consolidation, memory reconsolidation, long-term memory formation, non-coding RNA, chromatin modification, epigenetic modifications, synaptic plasticity, gene expression, de novo transcription
MeSH terms
Chromatin, Gene Expression Regulation, Humans, Models, Neurological, Neuronal Plasticity, Transcription Factors, Transcription, Genetic, RNA, Untranslated, Epigenesis, Genetic, Memory, Long-Term

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