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Cited by 37Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsGenetics and Neurodevelopmental Disorders

Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit

Open access
Díaz-Alonso, Javier, Morishita, Wade, Incontro, Salvatore, Simms, Jeffrey, Holtzman, Julia, Gill, Michael, Mucke, Lennart, Malenka, Robert C +1 more·2020·eLife
DOI 10.7554/elife.58042PMC PMC7500950
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Abstract

We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture passively diffusing AMPARs.

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  • Deletion of the CTD of GluA1 yields LTP indistinguishable from neighboring control cells.

    “Experiments in which the CTD of GluA1 is deleted (Refs. 273–275, but see Refs. 276, 277) express LTP that is indistinguishable from that in neighboring control cells.”

    From Synaptic memory and CaMKII (2023) · cites this paper as [274]

    The Results (Figure 2F–G; page unavailable) report that mice with a truncated GluA1 CTD had LTP no different from wild-type controls. But those controls were cells from wild-type mice, not neighboring control cells. The paper’s recordings from adjacent control cells involved GluA1 whose CTD was replaced with the GluA2 CTD, rather than simply deleted. (LLM, conf=0.84)

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Research works printed but not linked: 27

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Sorted by citations

Authors
Díaz-Alonso, J., Morishita, W., Incontro, S., Simms, J., Holtzman, J., Gill, M., Mucke, L., Malenka, R. C., & Nicoll, R. A.
Affiliations
  • University of California, San Francisco (US)
  • Stanford Medicine (US)
  • Gladstone Institutes (US)
Corresponding author
Nicoll, Roger A
ORCID
Venue
eLife
Publisher
eLife Sciences Publications, Ltd
Published
2020-08-24
Volume
9
ISSN
2050-084X (ISSN-L)
DOI
10.7554/elife.58042
PMC
PMC7500950
OpenAlex
W3081036817
Cited by
37
References
6
Citations by year
2026: 3 · 2025: 2 · 2024: 6 · 2023: 7 · 2022: 8 · 2021: 10 · 2020: 1
FWCI
2.98
Type
journal article
Language
en
Open access
Licence
Locations
  • eLife (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • eScholarship (California Digital Library) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
National Institute of Mental Health (K99MH118425, R01MH070957, R01MH117139, P50MH086403)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
long-term potentiation, GluR1, AMPA receptors, C-terminal domain, knock-in mice, spatial memory, synaptic plasticity, receptor diffusion
MeSH terms
Protein Domains, Animals, Cell Line, Female, Hippocampus, Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Long-Term Potentiation, Receptors, AMPA, Maze Learning, Mice, Gene Knock-In Techniques, Spatial Memory

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