The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?
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Abstract
The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected more than 10 million people, including pregnant women. To date, no consistent evidence for the vertical transmission of SARS-CoV-2 exists. The novel coronavirus canonically utilizes the angiotensin-converting enzyme 2 (ACE2) receptor and the serine protease TMPRSS2 for cell entry. Herein, building upon our previous single-cell study (Pique-Regi et al., 2019), another study, and new single-cell/nuclei RNA-sequencing data, we investigated the expression of ACE2 and TMPRSS2 throughout pregnancy in the placenta as well as in third-trimester chorioamniotic membranes. We report that co-transcription of ACE2 and TMPRSS2 is negligible in the placenta, thus not a likely path of vertical transmission for SARS-CoV-2. By contrast, receptors for Zika virus and cytomegalovirus, which cause congenital infections, are highly expressed by placental cell types. These data show that the placenta minimally expresses the canonical cell-entry mediators for SARS-CoV-2.
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Cites
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MethodInfluential
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Cited by
Vertical transmission of coronavirus disease 2019: a systematic review and meta-analysis
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An update on COVID-19 and pregnancy
Jamieson, D. J., & Rasmussen, S. A. (2022) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2021.08.054 · Cited by 466
Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2
Salamanna, F., Maglio, M., Landini, M. P., & Fini, M. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.594495 · Cited by 281
On the whereabouts of SARS-CoV-2 in the human body: A systematic review
Trypsteen, W., Van Cleemput, J., Snippenberg, W. V., Gerlo, S., & Vandekerckhove, L. (2020) · PLOS Pathogens · doi:10.1371/journal.ppat.1009037 · Cited by 199
Ashary, N., Bhide, A., Chakraborty, P., Colaco, S., Mishra, A., Chhabria, K., Jolly, M. K., & Modi, D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00783 · Cited by 121
Metadata
- Authors
- Pique-Regi, R., Romero, R., Tarca, A. L., Luca, F., Xu, Y., Alazizi, A., Leng, Y., Hsu, C.-D., & Gomez-Lopez, N.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2020-07-14
- Volume
- 9
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W3042513471
- Cited by
- 283
- References
- 122
- FWCI
- 33.33
- Type
- journal article
- Language
- en
- Open access
- gold
- Licence
- creativecommons.org/publicdomain/zero/1.0/ (vor)
- creativecommons.org/publicdomain/zero/1.0/ (am)
- creativecommons.org/publicdomain/zero/1.0/ (tdm)
- Funders
- National Institutes of Health (HHSN275201300006C)
- Wayne State University (Perinatal Research Initiative)
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- Pique-Regi, R., Romero, R., Tarca, A. L., Luca, F., Xu, Y., Alazizi, A., Leng, Y., Hsu, C.-D., & Gomez-Lopez, N. (2020). Does the human placenta express the canonical cell entry mediators for SARS-CoV-2? eLife. https://doi.org/10.7554/elife.58716
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