Viromes of one year old infants reveal the impact of birth mode on microbiome diversity
Open accessAbstract
Establishing a diverse gut microbiota after birth is being increasingly recognised as important for preventing illnesses later in life. It is well established that bacterial diversity rapidly increases post-partum; however, few studies have examined the infant gut virome/phageome during this developmental period. We performed a metagenomic analysis of 20 infant faecal viromes at one year of age to determine whether spontaneous vaginal delivery (SVD) or caesarean section (CS) influenced viral composition. We find that birth mode results in distinctly different viral communities, with SVD infants having greater viral and bacteriophage diversity. We demonstrate that CrAssphage is acquired early in life, both in this cohort and two others, although no difference in birth mode is detected. A previous study has shown that bacterial OTU’s (operational taxonomic units) identified in the same infants could not discriminate between birth mode at 12 months of age. Therefore, our results indicate that vertical transmission of viral communities from mother to child may play a role in shaping the early life microbiome, and that birth mode should be considered when studying the early life gut virome.
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Mode of delivery has an impact on the fecal virome of infants, with increased viral and bacteriophages diversity in babies born per vaginum.
“mode of delivery has an impact on the fecal virome of infants, with increased viral and bacteriophages diversity in babies born per vaginum (McCann et al., 2018).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as McCann et al., 2018
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- Authors
- McCann, A., Ryan, F. J., Stockdale, S. R., Dalmasso, M., Blake, T., Ryan, C. A., Stanton, C., Mills, S., Ross, P. R., & Hill, C.
- Affiliations
- University College Cork (IE)
- Teagasc - The Irish Agriculture and Food Development Authority (IE)
- Normandie Université (FR)
- Cork University Hospital (IE)
- APC Microbiome Institute, Cork, Cork, Ireland
- Corresponding author
- Hill, Colin
- ORCID
- Venue
- PeerJ
- Publisher
- PeerJ
- Published
- 2018-05-07
- Volume
- 6
- Pages
- e4694
- ISSN
- 2167-8359 (ISSN-L)
- PMC
- PMC5944432
- OpenAlex
- W2802528759
- Cited by
- 129
- References
- 2
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 11 · 2023: 11 · 2022: 16 · 2021: 28 · 2020: 16 · 2019: 20 · 2018: 4
- FWCI
- 12.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PeerJ (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
- Cork Open Research Archive (University College Cork, Ireland) (acceptedVersion, other-oa)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by)
- HAL (submittedVersion, other-oa)
- Cork Open Research Archive (University College Cork, Ireland) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- T-Stór (Teagasc) (submittedVersion, cc-by-nc-sa)
- Lenus, The Irish Health Repository (Dr Steevens Hospital Library) (submittedVersion)
- Funders
- Science Foundation Ireland (SFI) (12/RC/2273)
- Irish Department of Agriculture, Food and Marine
- Topics
- Physical Sciences › Environmental Science › Ecology › Bacteriophages and microbial interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- phageome, mode of delivery, cesarean section, normal delivery, crAssphage, vertical transmission, early-life microbiota, one-year-old children
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