Outcomes Following Placement of Non–Cross-Linked Porcine-Derived Acellular Dermal Matrix in Complex Ventral Hernia Repair
Open accessAbstract
Repair of complex ventral hernias frequently results in postoperative complications. This study assessed postoperative outcomes in a consecutive cohort of patients with ventral hernias who underwent herniorrhaphy using components separation techniques and reinforcement with non–cross-linked intact porcine-derived acellular dermal matrix (PADM) performed by a single surgeon between 2008 and 2012. Postoperative outcomes of interest included incidence of seroma, wound infection, deep-vein thrombosis, bleeding, and hernia recurrence determined via clinical examination. Of the 47 patients included in the study, 25% were classified as having Ventral Hernia Working Group grade 1 risk, 62% as grade 2, 2% as grade 3, and 11% as grade 4; 49% had undergone previous ventral hernia repair. During a mean follow-up of 31 months, 3 patients experienced hernia recurrence, and 9 experienced other postoperative complications: 4 (9%) experienced deep-vein thrombosis; 3 (6%), seroma; 2 (4%), wound infection; and 2 (4%), bleeding. The use of PADM reinforcement following components separation resulted in low rates of postoperative complications and hernia recurrence in this cohort of patients undergoing ventral hernia repair.
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Uncrosslinked ECM scaffolds are a risky option in scenarios where a challenging mechanical load is required, such as tendon augmentation or ventral hernia repair, leading to bulging or mechanical failure.
“As a result, uncrosslinked ECM scaffolds are a risky option in scenarios where a challenging mechanical load is required, such as tendon augmentation [68,[204][205][206] or ventral hernia repair [207,208], leading to bulging or mechanical failure [191].”
From Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review (2025) · cites this paper as [207]
The citation to this paper is attached to ventral hernia repair, not tendon augmentation or the later bulging/mechanical-failure clause. For that application, the Discussion and Conclusion report low complication and recurrence rates after repair reinforced with non–cross-linked PADM, contrary to presenting it as a risky option. The study observed three recurrences among 47 patients during a mean 31-month follow-up. (LLM, conf=0.89)
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- Authors
- Golla, D., & Russo, C. C.
- Affiliations
- Golla Center for Plastic Surgery, Pittsburgh, Pennsylvania, USA
- Venue
- International Surgery
- Publisher
- International College of Surgeons
- Published
- 2014
- Volume
- 99
- Issue
- 3
- Pages
- 235-240
- ISSN
- 0020-8868 (ISSN-L)
- 2520-2456
- PMC
- PMC4027906
- OpenAlex
- W2080164024
- Cited by
- 8
- References
- 45
- Citations by year
- 2025: 1 · 2021: 1 · 2019: 1 · 2018: 3 · 2016: 2
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- International Surgery (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Hernia repair and management
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Surgery › Congenital Anomalies and Fetal Surgery
- Keywords
- ventral hernia repair, acellular dermal matrix, hernia repair, postoperative complications, hernia recurrence, seroma, wound infection, deep vein thrombosis, hemorrhage, mesh reinforcement
- MeSH terms
- Adult, Aged, Aged, 80 and over, Animals, Female, Hernia, Ventral, Humans, Male, Middle Aged, Retrospective Studies, Surgical Mesh, Swine, Cohort Studies, Comorbidity, Treatment Outcome, Herniorrhaphy, Acellular Dermis
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