Vitek, Michael P.

Tau is essential to β-amyloid-induced neurotoxicity

Rapoport, M., Dawson, H. N., Binder, L. I., Vitek, M. P., & Ferreira, A. (2002) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 807

Advanced glycation end products contribute to amyloidosis in Alzheimer disease

Vitek, M. P., Bhattacharya, K., Glendening, J. M., Stopa, E., Vlassara, H., Bucala, R., Manogue, K., & Cerami, A. (1994) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsAdvanced Glycation End Products research

Cited by 806

Nitric oxide and redox mechanisms in the immune response

Wink, D. A., Hines, H. B., Cheng, R. Y. S., Switzer, C. H., Flores-Santana, W., Vitek, M. P., Ridnour, L. A., & Colton, C. A. (2011) · Journal of Leukocyte Biology

Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stress

Cited by 765

Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

Rissman, R. A., Poon, W. W., Blurton-Jones, M., Oddo, S., Torp, R., Vitek, M. P., LaFerla, F. M., Rohn, T. T., & Cotman, C. W. (2004) · Journal of Clinical Investigation

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 543

Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice

Dawson, H. N., Ferreira, A., Eyster, M. V., Ghoshal, N., Binder, L. I., & Vitek, M. P. (2001) · Journal of Cell Science

Alzheimer's disease research and treatmentsNeurogenesis and neuroplasticity mechanisms

Cited by 527

Microvascular injury and blood–brain barrier leakage in Alzheimer's disease

Zipser, B. D., Johanson, C. E., Gonzalez, L., Berzin, T. M., Tavares, R., Hulette, C. M., Vitek, M. P., Hovanesian, V., & Stopa, E. G. (2007) · Neurobiology of Aging

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 487

APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response

Lynch, J. R., Tang, W., Wang, H., Vitek, M. P., Bennett, E. R., Sullivan, P. M., Warner, D. S., & Laskowitz, D. T. (2003) · Journal of Biological Chemistry

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 394

Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD.

Colton, C. A., Mott, R. T., Sharpe, H. J., Xu, Q., Nostrand, W. E. V., & Vitek, M. P. (2006) · Journal of Neuroinflammation

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 393

APOE genotype-specific differences in the innate immune response

Vitek, M. P., Brown, C. M., & Colton, C. A. (2009) · Neurobiology of Aging

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 362

Tau Protein Is Required for Amyloid β-Induced Impairment of Hippocampal Long-Term Potentiation

Shipton, O. A., Leitz, J. R., Dworzak, J., Acton, C. E. J., Tunbridge, E. M., Denk, F., Dawson, H. N., Vitek, M. P., Wade-Martins, R., Paulsen, O., et al. (2011) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 315

Akt Activation Protects Hippocampal Neurons from Apoptosis by Inhibiting Transcriptional Activity of p53

Yamaguchi, A., Tamatani, M., Matsuzaki, H., Namikawa, K., Kiyama, H., Vitek, M. P., Mitsuda, N., & Tohyama, M. (2001) · Journal of Biological Chemistry

Cell death mechanisms and regulationPI3K/AKT/mTOR signaling in cancer

Cited by 242

Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways

Ridnour, L. A., Windhausen, A. N., Isenberg, J. S., Yeung, N., Thomas, D. D., Vitek, M. P., Roberts, D. D., & Wink, D. A. (2007) · Proceedings of the National Academy of Sciences

Protease and Inhibitor MechanismsNitric Oxide and Endothelin Effects

Cited by 219

Tau – an inhibitor of deacetylase HDAC6 function

Perez, M., Santa‐Maria, I., De Barreda, E. G., Zhu, X., Cuadros, R., Cabrero, J. R., Sanchez‐Madrid, F., Dawson, H. N., Vitek, M. P., Perry, G., et al. (2009) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsHistone Deacetylase Inhibitors Research

Cited by 182

Targeting SET/I2PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy

Switzer, C. H., Cheng, R. Y. S., Vitek, T. M., Christensen, D. J., Wink, D. A., & Vitek, M. P. (2011) · Oncogene

Protein Kinase Regulation and GTPase SignalingMechanisms of cancer metastasis

Cited by 171

NO synthase 2 ( NOS2 ) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease

Colton, C. A., Vitek, M. P., Wink, D. A., Xu, Q., Cantillana, V., Previti, M. L., Van Nostrand, W. E., Weinberg, J. B., & Dawson, H. (2006) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 128

Apolipoprotein E and Peptide Mimetics Modulate Inflammation by Binding the SET Protein and Activating Protein Phosphatase 2A

Christensen, D. J., Ohkubo, N., Oddo, J., Van Kanegan, M. J., Neil, J., Li, F., Colton, C. A., & Vitek, M. P. (2011) · The Journal of Immunology

Protein Tyrosine PhosphatasesNF-κB Signaling Pathways

Cited by 125

Targeting Inhibitors of the Tumor Suppressor PP2A for the Treatment of Pancreatic Cancer

Farrell, A. S., Allen-Petersen, B., Daniel, C. J., Wang, X., Wang, Z., Rodriguez, S., Impey, S., Oddo, J., Vitek, M. P., Lopez, C., et al. (2014) · Molecular Cancer Research

Pancreatic and Hepatic Oncology ResearchSignaling Pathways in Disease

Cited by 114

Effect of APOE genotype on microvascular basement membrane in Alzheimer's disease

Salloway, S., Gur, T., Berzin, T., Zipser, B., Correia, S., Hovanesian, V, Fallon, J., Kuo-Leblanc, V, Glass, D., Hulette, C., et al. (2002) · Journal of the Neurological Sciences

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 113

Translational animal models for Alzheimer's disease: An Alzheimer's Association Business Consortium Think Tank

Vitek, M. P., Araujo, J. A., Fossel, M., Greenberg, B. D., Howell, G. R., Rizzo, S. J. S., Seyfried, N. T., Tenner, A. J., Territo, P. R., Windisch, M., et al. (2020) · Alzheimer's & Dementia: Translational Research & Clinical Interventions

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 103

Apolipoprotein E isoform mediated regulation of nitric oxide release

Brown, C. M., Wright, E., Colton, C. A., Sullivan, P. M., Laskowitz, D. T., & Vitek, M. P. (2002) · Free Radical Biology and Medicine

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 84

APOE genotype-specific differences in human and mouse macrophage nitric oxide production

Colton, C. A., Needham, L. K., Brown, C., Cook, D., Rasheed, K., Burke, J. R., Strittmatter, W. J., Schmechel, D. E., & Vitek, M. P. (2004) · Journal of Neuroimmunology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 75

Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer

Switzer, C. H., Glynn, S. A., Ridnour, L. A., Cheng, R. Y.-S., Vitek, M. P., Ambs, S., & Wink, D. A. (2011) · Trends in Pharmacological Sciences

Breast Cancer Treatment StudiesNitric Oxide and Endothelin Effects

Cited by 74

Sex steroids, APOE genotype and the innate immune system

Colton, C. A., Brown, C. M., & Vitek, M. P. (2005) · Neurobiology of Aging

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 71

Role of MAP1B in axonal retrograde transport of mitochondria

Jiménez-Mateos, E.-M., González-Billault, C., Dawson, H. N., Vitek, M. P., & Avila, J. (2006) · Biochemical Journal

Microtubule and mitosis dynamicsAlzheimer's disease research and treatments

Cited by 70