Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD

Colton, Carol A; Mott, Ryan T; Sharpe, Hayley; Xu, Qing; Van Nostrand, William E; Vitek, Michael P

doi:10.1186/1742-2094-3-27

Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD

BackgroundMicroglia are associated with neuritic plaques in Alzheimer disease (AD) and serve as a primary component of the innate immune response in the brain. Neuritic plaques are fibrous deposits composed of the amyloid beta-peptide fragments (Abeta) of the amyloid precursor protein (APP). Nume…