Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

Neuropathological stageing of Alzheimer-related changes.

Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673 · see citing works

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works

Mild Cognitive Impairment: Clinical Characterization and Outcome

Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1999) · Archives of Neurology · doi:10.1001/archneur.56.3.303 · Cited by 8,980 · see citing works

Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126 · see citing works

Neurodegenerative Tauopathies

Lee, V. M.-Y., Goedert, M., & Trojanowski, J. Q. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1121 · Cited by 2,480 · see citing works

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work.

Buée, L., Bussière, T., Buée‐Scherrer, V., Delacourte, A., & Hof, P. R. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00019-9 · Cited by 2,007 · see citing works

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

Grundke, I., Iqbal, K., Quinlan, M., Tung, Y. C., Zaidi, M. S., & Wisniewski, H. M. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38495-8 · Cited by 1,780 · see citing works

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP

Lewis, J., Dickson, D. W., Lin, W.-L., Chisholm, L., Corral, A., Jones, G., Yen, S.-H., Sahara, N., Skipper, L., Yager, D., et al. (2001) · Science · doi:10.1126/science.1058189 · Cited by 1,611 · see citing works

Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

Götz, J., Chen, F., van Dorpe, J., & Nitsch, R. M. (2001) · Science · doi:10.1126/science.1062097 · Cited by 1,526 · see citing works

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

Loo, D. T., Copani, A., Pike, C. J., Whittemore, E. R., Walencewicz, A. J., & Cotman, C. W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7951 · Cited by 1,030 · see citing works

Intraneuronal Aβ42 Accumulation in Human Brain

Gouras, G. K., Tsai, J., Naslund, J., Vincent, B., Edgar, M., Checler, F., Greenfield, J. P., Haroutunian, V., Buxbaum, J. D., Xu, H., et al. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64700-1 · Cited by 991 · see citing works

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease

Oddo, S. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.08.012 · Cited by 980 · see citing works

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau.

Drechsel, D. N., Hyman, A. A., Cobb, M. H., & Kirschner, M. W. (1992) · Molecular Biology of the Cell · doi:10.1091/mbc.3.10.1141 · Cited by 971 · see citing works

Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments

Alonso, A. D. C., Zaidi, T., Novák, M., Grundke, I., & Iqbal, K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121119298 · Cited by 968 · see citing works

Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding

Bramblett, G. T., Goedert, M., Jakes, R., Merrick, S. E., Trojanowski, J. Q., & Lee, V. M. Y. (1993) · Neuron · doi:10.1016/0896-6273(93)90057-x · Cited by 903 · see citing works

Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

Stamer, K., Vogel, R., Thies, E., Mandelkow, E., & Mandelkow, E.-M. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200108057 · Cited by 885 · see citing works

Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease

Gamblin, T. C., Chen, F., Zambrano, A., Abraha, A., Lagalwar, S., Guillozet, A. L., Lu, M., Fu, Y., Garcia-Sierra, F., LaPointe, N., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1630428100 · Cited by 831 · see citing works

Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: Implications for Alzheimer’s disease

Ebneth, A., Godemann, R., Stamer, K., Illenberger, S., Trinczek, B., Mandelkow, E.-M., & Mandelkow, E. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.3.777 · Cited by 820 · see citing works

Tau is essential to β-amyloid-induced neurotoxicity

Rapoport, M., Dawson, H. N., Binder, L. I., Vitek, M. P., & Ferreira, A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092136199 · Cited by 807 · see citing works

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding

Biernat, J., Gustke, N., Drewes, G., Mandelkow, E., & Mandelkow, E. (1993) · Neuron · doi:10.1016/0896-6273(93)90279-z · Cited by 796 · see citing works

Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation

Gervais, F. G., Xu, D., Robertson, G. S., Vaillancourt, J. P., Zhu, Y., Huang, J., LeBlanc, A. C., Smith, D., Rigby, M., Shearman, M. S., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80748-5 · Cited by 783 · see citing works

Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms

Andorfer, C., Kress, Y., Espinoza, M., De Silva, R., Tucker, K. L., Barde, Y., Duff, K., & Davies, P. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01879.x · Cited by 722 · see citing works

Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology

Takahashi, R. H., Milner, T. A., Li, F., Nam, E. E., Edgar, M. A., Yamaguchi, H., Beal, M. F., Xu, H., Greengard, P., & Gouras, G. K. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64463-x · Cited by 706 · see citing works

Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons

Cáceres, A., & Kosik, K. S. (1990) · Nature · doi:10.1038/343461a0 · Cited by 657 · see citing works

Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205

Goedert, M., Jakes, R., & Vanmechelen, E. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11484-e · Cited by 608 · see citing works

Structural characterization of the core of the paired helical filament of Alzheimer disease.

Wischik, C. M., Novák, M., Edwards, P. C., Klug, A., Tichelaar, W., & Crowther, R. A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.13.4884 · Cited by 597 · see citing works

Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau.

Greenberg, S. G., Davies, P., Schein, J., & Binder, L. I. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48531-6 · Cited by 542 · see citing works

Proteolysis of Fodrin (Non-erythroid Spectrin) during Apoptosis

Martin, S. J., O'Brien, G. A., Nishioka, W. K., McGahon, A. J., Mahboubi, A., Saido, T. C., & Green, D. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.12.6425 · Cited by 528 · see citing works

Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice

Dawson, H. N., Ferreira, A., Eyster, M. V., Ghoshal, N., Binder, L. I., & Vitek, M. P. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.6.1179 · Cited by 527 · see citing works

Epitopes that span the tau molecule are shared with paired helical filaments

Kosik, K. S., Orecchio, L. D., Binder, L. I., Trojanowski, J. Q., Lee, V. M.-Y., & Lee, G. S. (1988) · Neuron · doi:10.1016/0896-6273(88)90129-8 · Cited by 497 · see citing works

Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

Jackson, G. R., Wiedau-Pazos, M., Sang, T.-K., Wagle, N., Brown, C. A., Massachi, S., & Geschwind, D. H. (2002) · Neuron · doi:10.1016/s0896-6273(02)00706-7 · Cited by 488 · see citing works

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells

Lovestone, S., Reynolds, C. H., Latimer, D. A., Davis, D. R., Anderton, B. H., Gallo, J., Hanger, D. P., Mulot, S., Marquardt, B., Stabel, S., et al. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00246-3 · Cited by 470 · see citing works

Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death.

Stadelmann, C., Deckwerth, T., Srinivasan, A., Bancher, C., Brück, W., Jellinger, K. A., & Lassmann, H. (1999) · American Journal of Pathology · doi:10.1016/s0002-9440(10)65460-0 · Cited by 449 · see citing works

The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.

Goedert, M., Jakes, R., Crowther, R. A., Six, J., Lübke, U., Vandermeeren, M., Cras, P., Trojanowski, J. Q., & Lee, V. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.11.5066 · Cited by 446 · see citing works

Selective cytotoxicity of intracellular amyloid β peptide1–42 through p53 and Bax in cultured primary human neurons

Zhang, Y., McLaughlin, R., Goodyer, C., & LeBlanc, A. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200110119 · Cited by 418 · see citing works

The Structural Basis of Monoclonal Antibody Alz50's Selectivity for Alzheimer's Disease Pathology

Carmel, G., Mager, E. M., Binder, L. I., & Kuret, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32789 · Cited by 402 · see citing works

Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament

Novak, M., Kabat, J., & Wischik, C. M. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05665.x · Cited by 398 · see citing works

Altered Metabolism of the Amyloid β Precursor Protein Is Associated with Mitochondrial Dysfunction in Down's Syndrome

Busciglio, J., Pelsman, A., Wong, C., Pigino, G., Yuan, M., Mori, H., & Yankner, B. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00604-9 · Cited by 387 · see citing works

Neurodegeneration and defective neurotransmission in a <i>Caenorhabditis elegans</i> model of tauopathy

Kraemer, B. C., Zhang, B., Leverenz, J. B., Thomas, J. H., Trojanowski, J. Q., & Schellenberg, G. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1533448100 · Cited by 379 · see citing works

Neuritic pathology and dementia in alzheimer's disease

McKee, A. C., Kosik, K. S., & Kowall, N. W. (1991) · Annals of Neurology · doi:10.1002/ana.410300206 · Cited by 358 · see citing works

Toward a unified scheme for the aggregation of tau into Alzheimer paired helical filaments

Barghorn, S., & Mandelkow, E. (2002) · Biochemistry · doi:10.1021/bi026469j · Cited by 341 · see citing works

A nucleated assembly mechanism of Alzheimer paired helical filaments

Friedhoff, P., von Bergen�, M., Mandelkow�, E., Davies, P., & Mandelkow�, E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15712 · Cited by 340 · see citing works

Evidence for Synaptic Apoptosis

Mattson, M. P., Keller, J. N., & Begley, J. G. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6863 · Cited by 340 · see citing works

Intraneuronal Aβ accumulation precedes plaque formation in β-amyloid precursor protein and presenilin-1 double-transgenic mice

Wirths, O., Multhaup, G., Czech, C., Blanchard, V., Moussaoui, S., Tremp, G., Pradier, L., Beyreuther, K., & Bayer, T. A. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01876-6 · Cited by 336 · see citing works

C-terminal inhibition of tau assembly in vitro and in Alzheimer’s disease

Abraha, A., Ghoshal, N., Gamblin, T. C., Cryns, V. L., Berry, R. W., Kuret, J., & Binder, L. I. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.21.3737 · Cited by 326 · see citing works

Conformational change as one of the earliest alterations of tau in Alzheimer's disease

Weaver, C. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00157-3 · Cited by 310 · see citing works

β-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease

Cummings, B. J., Pike, C. J., Shankle, R., & Cotman, C. W. (1996) · Neurobiology of Aging · doi:10.1016/s0197-4580(96)00170-4 · Cited by 305 · see citing works

Microtubule-Associated Protein Tau

Yen, S.-H. C., Nacharaju, P., Ko, L., Kenessey, Á., & Liu, W.-K. (1998) · Elsevier eBooks · doi:10.1016/b978-012734610-6/50012-9 · Cited by 284 · see citing works

Caspase 3 activation is essential for neuroprotection in preconditioning

McLaughlin, B., Hartnett, K. A., Erhardt, J. A., Legos, J. J., White, R. F., Barone, F. C., & Aizenman, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0232966100 · Cited by 271 · see citing works

Activated caspase-3 expression in Alzheimer’s and aged control brain: correlation with Alzheimer pathology

Su, J. H., Zhao, M., Anderson, A. J., Srinivasan, A. N., & Cotman, C. W. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02018-2 · Cited by 260 · see citing works

Amyloid β-peptide induces apoptosis-related events in synapses and dendrites

Mattson, M. P., Partin, J. V., & Begley, J. G. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00763-x · Cited by 260 · see citing works

Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease.

Yang, F., Sun, X., Beech, W. K., Teter, B., Wu, S. S. H., Sigel, J. J., Vinters, H. V., Frautschy, S. A., & Cole, G. M. (1998) · Europe PMC (PubMed Central) · Cited by 245 · see citing works

Caspase-9 Activation and Caspase Cleavage of tau in the Alzheimer's Disease Brain

Rohn, T. T., Rissman, R. A., Davis, M. C., Kim, Y., Cotman, C. W., & Head, E. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0549 · Cited by 242 · see citing works

Memory and mental status correlates of modified Braak staging.

Grober, E., Dickson, D., Sliwinski, M., Buschke, H., Katz, M., Crystal, H., & Lipton, R. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00063-9 · Cited by 242 · see citing works

Tau Cleavage and Dephosphorylation in Cerebellar Granule Neurons Undergoing Apoptosis

Canu, N., Dus, L., Barbato, C., Ciotti, M. T., Brancolini, C., Rinaldi, A. M., Novak, M., Cattaneo, A., Bradbury, A., & Calissano, P. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-18-07061.1998 · Cited by 232 · see citing works

Proapoptotic Effects of Tau Cleavage Product Generated by Caspase-3

Chung, C.-W., Song, Y.-H., Kim, I.-K., Yoon, W. J., Ryu, B. R., Jo, D., Woo, H., Kwon, Y.-K., Kim, H., Gwag, B.-J., et al. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0335 · Cited by 211 · see citing works

The Neuronal Microtubule‐Associated Protein Tau Is a Substrate for Caspase‐3 and an Effector of Apoptosis

Fasulo, L., Ugolini, G., Visintin, M., Bradbury, A. M., Brancolini, C., Verzillo, V., Novák, M., & Cattaneo, A. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750624.x · Cited by 195 · see citing works

Staging of Cytoskeletal and β-Amyloid Changes in Human Isocortex Reveals Biphasic Synaptic Protein Response during Progression of Alzheimer’s Disease

Mukaetova‐Ladinska, E. B., García‐Sierra, F., Hurt, J., Gertz, H.-J., Xuereb, J. H., Hills, R., Brayne, C., Huppert, F. A., Paykel, E. S., McGee, M. A., et al. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64573-7 · Cited by 187 · see citing works

Neuronal Apoptosis Induced by β-Amyloid Is Mediated by Caspase-8

Ivins, K. J., Thornton, P. L., Rohn, T. T., & Cotman, C. W. (1999) · Neurobiology of Disease · doi:10.1006/nbdi.1999.0268 · Cited by 187 · see citing works

β-Amyloid Induces Paired Helical Filament-like Tau Filaments in Tissue Culture

Ferrari, A., Hoerndli, F. J., Baechi, T., Nitsch, R. M., & Götz, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308243200 · Cited by 182 · see citing works

Activation of Caspase-8 in the Alzheimer's Disease Brain

Rohn, T. T., Head, E., Nesse, W. H., Cotman, C. W., & Cribbs, D. H. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0449 · Cited by 171 · see citing works

Correlation between Caspase Activation and Neurofibrillary Tangle Formation in Alzheimer’s Disease

Rohn, T. T., Head, E., Su, J. H., Anderson, A. J., Bahr, B. A., Cotman, C. W., & Cribbs, D. H. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63957-0 · Cited by 164 · see citing works

Oxidative Regulation of Fatty Acid-Induced Tau Polymerization

Gamblin, T. C., King, M. E., Kuret, J., Berry, R. W., & Binder, L. I. (2000) · Biochemistry · doi:10.1021/bi001876l · Cited by 151 · see citing works

Transgenic Mouse Model of Tauopathies with Glial Pathology and Nervous System Degeneration

Higuchi, M., Ishihara, T., Zhang, B., Hong, M., Andreadis, A., Trojanowski, J. Q., & Lee, V. M. ‐. (2002) · Neuron · doi:10.1016/s0896-6273(02)00789-4 · Cited by 149 · see citing works

Inhibition of Tau Polymerization by Its Carboxy-Terminal Caspase Cleavage Fragment

Berry, R. W., Abraha, A., Lagalwar, S., LaPointe, N., Gamblin, T. C., Cryns, V. L., & Binder, L. I. (2003) · Biochemistry · doi:10.1021/bi027348m · Cited by 141 · see citing works

Nonsaturable Binding Indicates Clustering of Tau on the Microtubule Surface in a Paired Helical Filament-like Conformation

Ackmann, M., Wiech, H., & Mandelkow�, E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002590200 · Cited by 131 · see citing works

C‐terminal 15 kDa fragment of cytoskeletal actin is posttranslationally N‐myristoylated upon caspase‐mediated cleavage and targeted to mitochondria

Utsumi, T., Sakurai, N., Nakano, K., & Ishisaka, R. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00180-7 · Cited by 124 · see citing works

Sequence requirements for formation of conformational variants of tau similar to those found in Alzheimer's disease

Jicha, G. A., Berenfeld, B., & Davies, P. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990315)55:6 · Cited by 123 · see citing works

Multiple Caspases Are Activated after Traumatic Brain Injury: Evidence for Involvement in Functional Outcome

Knoblach, S. M., Nikolaeva, M. A., Huang, X., Fan, L., Krajewski, S., Reed, J. C., & Faden, A. I. (2002) · Journal of Neurotrauma · doi:10.1089/08977150260337967 · Cited by 117 · see citing works

Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema

Lynch, J. R., Pineda, J. A., Morgan, D., Zhang, L., Warner, D. S., Benveniste, H., & Laskowitz, D. T. (2002) · Annals of Neurology · doi:10.1002/ana.10098 · Cited by 111 · see citing works

Apoptotic Neuronal Cell Death Induced by the Non-fibrillar Amyloid-β Peptide Proceeds through an Early Reactive Oxygen Species-dependent Cytoskeleton Perturbation

Sponne, I., Fifre, A., Drouet, B., Klein, C., Koziel, V., Pinçon‐Raymond, M., Olivier, J. L., Chambaz, J., & Pillot, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m206745200 · Cited by 108 · see citing works

Caspase activation in the limbic cortex of subjects with early Alzheimer's disease

Gastard, M. C., Troncoso, J. C., & Koliatsos, V. E. (2003) · Annals of Neurology · doi:10.1002/ana.10680 · Cited by 101 · see citing works

Multiple Pathways of Apoptosis in PC12 Cells

Ivins, K. J., Ivins, J. K., Sharp, J. P., & Cotman, C. W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2107 · Cited by 94 · see citing works

DEDD regulates degradation of intermediate filaments during apoptosis

Lee, J. C., Schickling, O., Stegh, A. H., Oshima, R. G., Dinsdale, D. D., Cohen, G. M., & Peter, M. E. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200112124 · Cited by 82 · see citing works

The kinder side of killer proteases: Caspase activation contributes to neuroprotection and CNS remodeling

McLaughlin, B. (2004) · APOPTOSIS · doi:10.1023/b:appt.0000018793.10779.dc · Cited by 80 · see citing works

Ultrastructural evidence of fibrillar β-amyloid associated with neuronal membranes in behaviorally characterized aged dog brains

Torp, R., Head, E., Milgram, N. W., Hahn, F. F., Ottersen, O. P., & Cotman, C. W. (2000) · Neuroscience · doi:10.1016/s0306-4522(99)00568-0 · Cited by 60 · see citing works

Caspase activation in the Alzheimer's disease brain: Tortuous and torturous

Rohn, T. T., Rissman, R. A., Head, E., & Cotman, C. W. (2002) · Drug News &amp; Perspectives · doi:10.1358/dnp.2002.15.9.740233 · Cited by 48 · cited 1× · see citing works

Formation of diffuse and fibrillar tangles in aging and early Alzheimer’s disease☆

Uboga, N. V., & Price, J. L. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00091-9 · Cited by 44 · see citing works

Tau phosphorylation during apoptosis of human SH-SY5Y neuroblastoma cells

Mookherjee, P., & Johnson, G. V. W. (2001) · Brain Research · doi:10.1016/s0006-8993(01)03074-8 · Cited by 36 · see citing works

Atypical role of proximal caspase-8 in truncated Tau-induced neurite regression and neuronal cell death.

Chung, C., Hong, Y.-M., Song, S.-M., Woo, H.-N., Choi, Y.-H., Rohn, T., & Jung, Y.-K. (2003) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.08.017 · Cited by 18 · see citing works

Untitled work

(1997) · doi:10.1002/(sici)1097-4547(19970415)48:2

Amyloid Precursor Protein Processing and Alzheimer's Disease

O'Brien, R. J., & Wong, P. C. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113613 · Cited by 2,061 · see citing works

Neuronal Cell Death

Fricker, M., Tolkovsky, A. M., Borutaitė, V., Coleman, M. P., & Brown, G. C. (2018) · Physiological Reviews · doi:10.1152/physrev.00011.2017 · Cited by 1,122 · see citing works

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994 · see citing works

Roles of tau protein in health and disease

Guo, T., Noble, W., & Hanger, D. P. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1707-9 · Cited by 1,003 · see citing works

Tau pathology in Alzheimer disease and other tauopathies

Iqbal, K., del C. Alonso, A., Chen, S., Chohan, M. O., El-Akkad, E., Gong, C.-X., Khatoon, S., Li, B., Liu, F., Rahman, A., et al. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.09.008 · Cited by 1,037 · see citing works

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary DegenerationPreprint

Mandelkow, E., & Mandelkow, E. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006247 · Cited by 848 · see citing works

Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome

Oddo, S., Billings, L., Kesslak, J. P., Cribbs, D. H., & LaFerla, F. M. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.003 · Cited by 780 · see citing works

Mitochondrial Defects and Oxidative Stress in Alzheimer Disease and Parkinson Disease

Yan, M. H., Wang, X., & Zhu, X. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.11.014 · Cited by 718 · see citing works

Post-translational modifications of tau protein: Implications for Alzheimer's disease

Martin, L., Latypova, X., & Terro, F. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2010.12.023 · Cited by 645 · see citing works

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

Wang, Y., Martinez-Vicente, M., Krüger, U., Kaushik, S., Wong, E., Mandelkow, E.-M., Cuervo, A. M., & Mandelkow, E. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp367 · Cited by 617 · see citing works

Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade

Savelieff, M. G., Nam, G., Kang, J., Lee, H. J., Lee, M., & Lim, M. H. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00138 · Cited by 603 · see citing works

Caspase activation precedes and leads to tangles

de Calignon, A., Fox, L. M., Pitstick, R., Carlson, G. A., Bacskai, B. J., Spires-Jones, T. L., & Hyman, B. T. (2010) · Nature · doi:10.1038/nature08890 · Cited by 517 · see citing works

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

Zhang, Z., Song, M., Liu, X., Kang, S. S., Kwon, I.-S., Duong, D. M., Seyfried, N. T., Hu, W. T., Liu, Z., Wang, J.-Z., et al. (2014) · Nature Medicine · doi:10.1038/nm.3700 · Cited by 494 · see citing works

Insulin in the Brain: Its Pathophysiological Implications for States Related with Central Insulin Resistance, Type 2 Diabetes and Alzheimer’s Disease

Blázquez, E., Velázquez, E., Hurtado-Carneiro, V., & Ruiz-Albusac, J. M. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00161 · Cited by 502 · see citing works

The role of tau in neurodegeneration

Gendron, T. F., & Petrucelli, L. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-13 · Cited by 478 · see citing works

The importance of tau phosphorylation for neurodegenerative diseases

Noble, W., Hanger, D. P., Miller, C. C. J., & Lovestone, S. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00083 · Cited by 475 · see citing works

Structure and Pathology of Tau Protein in Alzheimer Disease

Kolarova, M., García‐Sierra, F., Bartoš, A., Říčný, J., & Řı́pová, D. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/731526 · Cited by 473 · see citing works

Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process

De Strooper, B. (2010) · Physiological Reviews · doi:10.1152/physrev.00023.2009 · Cited by 455 · see citing works

Global Hairpin Folding of Tau in Solution

Jeganathan, S., von Bergen, M., Brutlach, H., Steinhoff, H.-J., & Mandelkow, E. (2006) · Biochemistry · doi:10.1021/bi0521543 · Cited by 432 · see citing works

Tau, tangles, and Alzheimer's disease.

Binder, L., Guillozet-Bongaarts, A. L., García-Sierra, F., & Berry, R. (2005) · Biochimica et Biophysica Acta · doi:10.1016/j.bbadis.2004.08.014 · Cited by 443 · see citing works

The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease

McManus, M. J., Murphy, M. P., & Franklin, J. L. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0552-11.2011 · Cited by 432 · see citing works

Alzheimer’s disease: insights into pathology, molecular mechanisms, and therapy

Zheng, Q., & Wang, X. (2024) · Protein & Cell · doi:10.1093/procel/pwae026 · Cited by 454 · see citing works

Microtubule-associated protein tau in development, degeneration and protection of neurons

Wang, J., & Liu, F. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.03.002 · Cited by 395 · see citing works

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture

Garwood, C. J., Pooler, A. M., Atherton, J., Hanger, D. P., & Noble, W. (2011) · Cell Death &amp; Disease · doi:10.1038/cddis.2011.50 · Cited by 379 · see citing works

Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation

Alquezar, C., Arya, S., & Kao, A. W. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2020.595532 · Cited by 367 · see citing works

Apoptotic cell death in disease—Current understanding of the NCCD 2023

Vitale, I., Pietrocola, F., Guilbaud, E., Aaronson, S. A., Abrams, J., Adam, D., Agostini, M., Agostinis, P., Alnemri, E. S., Altucci, L., et al. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01153-w · Cited by 359 · see citing works

Inducible Expression of Tau Repeat Domain in Cell Models of Tauopathy

Khlistunova, I., Biernat, J., Wang, Y., Pickhardt, M., von Bergen�, M., Gažová, Z., Mandelkow�, E., & Mandelkow, E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507753200 · Cited by 350 · see citing works

Inflammation in Alzheimer's disease: Amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors

Salminen, A., Ojala, J. O., Kauppinen, A., Kaarniranta, K., & Suuronen, T. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.01.001 · Cited by 347 · see citing works

Visualization of neurofibrillary tangle maturity in Alzheimer's disease: A clinicopathologic perspective for biomarker research

Moloney, C. M., Lowe, V. J., & Murray, M. E. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12321 · Cited by 337 · see citing works

ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology

Salminen, A., Kauppinen, A., Suuronen, T., Kaarniranta, K., & Ojala, J. O. (2009) · Journal of Neuroinflammation · doi:10.1186/1742-2094-6-41 · Cited by 327 · see citing works

Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease

Bellaver, B., Povala, G., Ferreira, P. C. L., Ferrari-Souza, J. P., Leffa, D. T., Lussier, F. Z., Benedet, A. L., Ashton, N. J., Triana-Baltzer, G., Kolb, H. C., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02380-x · Cited by 319 · see citing works

Chronic stress and glucocorticoids: From neuronal plasticity to neurodegeneration

Vyas, S., Rodrigues, A. J., Silva, J. M., Tronche, F., Almeida, O. F. X., Sousa, N., & Sotiropoulos, I. (2016) · Neural Plasticity · doi:10.1155/2016/6391686 · Cited by 297 · see citing works

The future of blood‐based biomarkers for Alzheimer's disease

Henriksen, K., O’Bryant, S. E., Hampel, H. J., Trojanowski, J. Q., Montine, T. J., Jeromin, A., Blennow, K., Lönneborg, A., Wyss‐Coray, T., Soares, H. D., et al. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.01.013 · Cited by 312 · see citing works

Glutamate system, amyloid β peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology

Revett, T. J., Baker, G. B., Jhamandas, J. H., & Kar, S. (2012) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.110190 · Cited by 294 · see citing works

Recurrent herpes simplex virus-1 infection induces hallmarks of neurodegeneration and cognitive deficits in mice

De Chiara, G., Piacentini, R., Fabiani, M., Mastrodonato, A., Marcocci, M. E., Limongi, D., Napoletani, G., Protto, V., Coluccio, P., Celestino, I., et al. (2019) · PLOS Pathogens · doi:10.1371/journal.ppat.1007617 · Cited by 266 · see citing works

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss

Tracy, T. E., Sohn, P. D., Minami, S. S., Wang, C., Min, S.-W., Li, Y., Zhou, Y., Le, D., Lo, I., Ponnusamy, R., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.005 · Cited by 277 · see citing works

Phosphorylation of tau protein at sites Ser 396–404 is one of the earliest events in A lzheimer's disease and D own syndrome

Mondragón‐Rodríguez, S., Perry, G. L., Luna‐Muñoz, J., Acevedo, M., & Williams, S. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12084 · Cited by 276 · see citing works

Deletion of the Ubiquitin Ligase CHIP Leads to the Accumulation, But Not the Aggregation, of Both Endogenous Phospho- and Caspase-3-Cleaved Tau Species

Dickey, C. A., Yue, M., Lin, W.-L., Dickson, D. W., Dunmore, J. H., Lee, W. C., Zehr, C., West, G., Cao, S., Clark, A. M. K., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0746-06.2006 · Cited by 248 · see citing works

Tau Proteins and Tauopathies in Alzheimer’s Disease

Chong, F. P., Ng, K. Y., Koh, R. Y., & Chye, S. M. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0574-1 · Cited by 248 · see citing works

Structural Principles of Tau and the Paired Helical Filaments of Alzheimer's Disease

Mandelkow, E., Von Bergen, M., Biernat, J., & Mandelkow, E. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00053.x · Cited by 243 · see citing works

Tau phosphorylation in Alzheimer's disease: pathogen or protector?

Lee, H., Perry, G. L., Moreira, P. I., Garrett, M. R., Liu, Q., Zhu, X., Takeda, A., Nunomura, A., & Smith, M. A. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2005.02.008 · Cited by 240 · see citing works

Dietary n‐3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease

Calon, F., Lim, G. P., Morihara, T., Yang, F., Ubeda, O. J., Salem, N., Frautschy, S. A., & Cole, G. M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04253.x · Cited by 244 · see citing works

Increased Tau Phosphorylation and Cleavage in Mouse Models of Type 1 and Type 2 Diabetes

Kim, B., Backus, C., Oh, S., Hayes, J. M., & Feldman, E. L. (2009) · Endocrinology · doi:10.1210/en.2009-0695 · Cited by 241 · see citing works

Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons

Pugazhenthi, S., Wang, M., Pham, S. T., Sze, C., & Eckman, C. B. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-60 · Cited by 240 · see citing works

Blood biomarkers for brain injury: What are we measuring?

Kawata, K., Liu, C. Y., Merkel, S. F., Ramirez, S. H., Tierney, R., & Langford, D. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.009 · Cited by 237 · see citing works

Earliest Stages of Tau Conformational Changes are Related to the Appearance of a Sequence of Specific Phospho-Dependent Tau Epitopes in Alzheimer's Disease1

Luna-Muñoz, J., Chávez-Macías, L., García-Sierra, F., & Mena, R. (2007) · Journal of Alzheimer's Disease · doi:10.3233/jad-2007-12410 · Cited by 233 · see citing works

Alzheimer's Disease-Like Pathology Induced by Amyloid-β Oligomers in Nonhuman Primates

Forny‐Germano, L., Silva, N. M. L. E., Batista, A. F., Brito‐Moreira, J., Gralle, M., Boehnke, S. E., Coe, B. C., Lablans, A., Marques, S. A., Martinez, A. M. B., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1353-14.2014 · Cited by 232 · see citing works

Caspase-3 activation as a bifurcation point between plasticity and cell death

Snigdha, S., Smith, E. D., Prieto, G. A., & Cotman, C. W. (2012) · Neuroscience Bulletin · doi:10.1007/s12264-012-1057-5 · Cited by 227 · see citing works

Tau Protein Interaction Partners and Their Roles in Alzheimer’s Disease and Other Tauopathies

Sinsky, J., Pichlerova, K., & Hanes, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179207 · Cited by 220 · see citing works

Propagation of tau pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies

Lewis, J. M., & Dickson, D. W. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1507-z · Cited by 221 · see citing works

Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease.

Chesser, A. S., Pritchard, S. M., & Johnson, G. V. W. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00122 · Cited by 219 · see citing works

Early N-Terminal Changes and Caspase-6 Cleavage of Tau in Alzheimer's Disease

Horowitz, P. M., Patterson, K. R., Guillozet-Bongaarts, A. L., Reynolds, M. R., Carroll, C. A., Weintraub, S. T., Bennett, D. A., Cryns, V. L., Berry, R. W., & Binder, L. I. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1988-04.2004 · Cited by 215 · see citing works

Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model

Wang, Y. P., Biernat, J., Pickhardt, M., Mandelkow�, E., & Mandelkow�, E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703676104 · Cited by 205 · see citing works

Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?

Dickson, D. W. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22317 · Cited by 201 · see citing works

The Role of Caspase Cleavage of Tau in Alzheimer Disease Neuropathology

Cotman, C. W., Poon, W. W., Rissman, R. A., & Blurton-Jones, M. (2005) · Journal of Neuropathology &amp; Experimental Neurology · doi:10.1093/jnen/64.2.104 · Cited by 199 · see citing works

β-Amyloid impairs axonal BDNF retrograde trafficking

Poon, W. W., Blurton-Jones, M. M., Tu, C. H., Feinberg, L. M., Chabrier, M. A., Harris, J. W., Jeon, N. L., & Cotman, C. W. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.05.012 · Cited by 198 · see citing works

It’s all about tau

Tapia‐Rojas, C., Cabezas-Opazo, F., Deaton, C. A., Vergara, E. H., Johnson, G. V. W., & Quintanilla, R. A. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.12.005 · Cited by 195 · see citing works

Beneficial effects of caffeine in a transgenic model of Alzheimer's disease-like tau pathology.

Laurent, C., Eddarkaoui, S., Derisbourg, M. J., Leboucher, A., Demeyer, D., Carrier, S., Schneider, M., Hamdane, M., Müller, C., Buée, L., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.027 · Cited by 189 · see citing works

Pathological tau promotes neuronal damage by impairing ribosomal function and decreasing protein synthesis

Meier, S., Bell, M., Lyons, D. N., Rodriguez-Rivera, J., Ingram, A., Fontaine, S. N., Mechas, E., Chen, J., Wolozin, B., LeVine, H., et al. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.3029-15.2016 · Cited by 190 · see citing works

Progression of Amyloid Pathology to Alzheimer's Disease Pathology in an Amyloid Precursor Protein Transgenic Mouse Model by Removal of Nitric Oxide Synthase 2

Wilcock, D. M., Lewis, M. R., Nostrand, W. E. V., Davis, J., Previti, M. L., Gharkholonarehe, N., Vitek, M. P., & Colton, C. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5066-07.2008 · Cited by 187 · see citing works

Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues

Muraoka, S., DeLeo, A. M., Sethi, M. K., Takamatsu-Yukawa, K., Yang, Z., Ko, J., Hogan, J., Ruan, Z., You, Y., Wang, Y., et al. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12089 · Cited by 189 · see citing works

Tau Proteolysis in the Pathogenesis of Tauopathies: Neurotoxic Fragments and Novel Biomarkers

Quinn, J. P., Corbett, N. J., Kellett, K. A. B., & Hooper, N. M. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-170959 · Cited by 170 · see citing works

Transgenic mouse models of alzheimer disease: Developing a better model as a tool for therapeutic interventions.

Kitazawa, M., Medeiros, R., & M. LaFerla, F. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799315786 · Cited by 178 · see citing works

Caspase-cleaved Tau Expression Induces Mitochondrial Dysfunction in Immortalized Cortical Neurons

Quintanilla, R. A., Matthews-Roberson, T. A., Dolan, P. J., & Johnson, G. V. W. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808908200 · Cited by 170 · see citing works

Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo

Guillozet-Bongaarts, A. L., Cahill, M. E., Cryns, V. L., Reynolds, M. R., Berry, R. W., & Binder, L. I. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03784.x · Cited by 169 · see citing works

MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways

Fatimy, R. E., Li, S., Chen, Z., Mushannen, T., Gongala, S., Wei, Z., Balu, D. T., Rabinovsky, R., Cantlon, A., Elkhal, A., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1880-5 · Cited by 170 · see citing works

Mechanisms of Insulin Resistance at the Crossroad of Obesity with Associated Metabolic Abnormalities and Cognitive Dysfunction

Barber, T. M., Kyrou, I., Randeva, H. S., & Weickert, M. O. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020546 · Cited by 177 · see citing works

ERK1/2 Activation Mediates Aβ Oligomer-induced Neurotoxicity via Caspase-3 Activation and Tau Cleavage in Rat Organotypic Hippocampal Slice Cultures

Chong, Y. H., Shin, Y. J., Lee, E. O., Kayed, R., Glabe, C. G., & Tenner, A. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601016200 · Cited by 164 · see citing works

Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies

Limorenko, G., & Lashuel, H. A. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00127b · Cited by 162 · see citing works

Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain

Rohn, T. T., Wirawan, E., Brown, R. J., Harris, J. R., Masliah, E., & Vandenabeele, P. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.11.003 · Cited by 160 · see citing works

Relationship Between Tau Pathology and Neuroinflammation in Alzheimer's Disease

Metcalfe, M., & Figueiredo‐Pereira, M. E. (2010) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20163 · Cited by 158 · see citing works

Contribution of Tau Pathology to Mitochondrial Impairment in Neurodegeneration

Maria Jose Perez, J., Jara, C., & Quintanilla, R. A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00441 · Cited by 153 · see citing works

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation

Mok, S., Condello, C., Freilich, R., Gillies, A. T., Arhar, T., Oroz, J., Kadavath, H., Julien, O., Assimon, V. A., Rauch, J. N., et al. (2018) · Nature Structural & Molecular Biology · doi:10.1038/s41594-018-0057-1 · Cited by 145 · see citing works

Accumulation of Aspartic Acid 421 - and Glutamic Acid 391 -Cleaved Tau in Neurofibrillary Tangles Correlates With Progression in Alzheimer Disease

Basurto‐Islas, G., Luna‐Muñoz, J., Guillozet-Bongaarts, A. L., Binder, L. I., Mena, R., & García‐Sierra, F. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31817275c7 · Cited by 150 · see citing works

Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo

Khurana, V., Elson‐Schwab, I., Fulga, T. A., Sharp, K. A., Loewen, C. A., Mulkearns-Hubert, E. E., Tyynelä, J., Scherzer, C. R., & Feany, M. Β. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001026 · Cited by 148 · see citing works

A Caspase Cleaved Form of Tau Is Preferentially Degraded through the Autophagy Pathway

Dolan, P. J., & Johnson, G. V. W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.110940 · Cited by 147 · see citing works

Lack of Pathology in a Triple Transgenic Mouse Model of Alzheimer’s Disease after Overexpression of the Anti-Apoptotic Protein Bcl-2

Rohn, T. T., Vyas, V., Hernandez-Estrada, T., Nichol, K. E., Christie, L.-A., & Head, E. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5620-07.2008 · Cited by 146 · see citing works

Hyperphosphorylation and Cleavage at D421 Enhance Tau Secretion

Plouffe, V., Mohamed, N., Rivest‐McGraw, J., Bertrand, J., Lauzon, M., & Leclerc, N. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036873 · Cited by 146 · see citing works

Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer’s disease

Mondragón‐Rodríguez, S., Basurto‐Islas, G., Santa‐María, I., Mena, R., Binder, L. I., Ávila, J., Smith, M. A., Perry, G. L., & García‐Sierra, F. (2008) · International Journal of Experimental Pathology · doi:10.1111/j.1365-2613.2007.00568.x · Cited by 146 · see citing works

Insulin resistance and cognitive dysfunction

Ma, L., Wang, J., & Li, Y. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.01.027 · Cited by 145 · see citing works

Tau-Based Treatment Strategies in Neurodegenerative Diseases

Schneider, A., & Mandelkow�, E. (2008) · Neurotherapeutics · doi:10.1016/j.nurt.2008.05.006 · Cited by 142 · see citing works

The neuropathological profile of mild cognitive impairment (MCI): a systematic review

Stephan, B. C. M., Hunter, S., Harris, D., Llewellyn, D. J., Siervo, M., Matthews, F. E., & Brayne, C. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.147 · Cited by 139 · see citing works

The role of tau phosphorylation and cleavage in neuronal cell death

Chun, W. (2006) · Frontiers in bioscience · doi:10.2741/2097 · Cited by 142 · see citing works

Neuroprotective Effects of Polysaccharides from Wolfberry, the Fruits of Lycium barbarum, Against Homocysteine-induced Toxicity in Rat Cortical Neurons

Ho, J. Y. S., Yu, M.-S., Yang, X., So, K., Yuen, W.-H., & Chang, R. C. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1280 · Cited by 142 · see citing works

Lysine-Directed Post-translational Modifications of Tau Protein in Alzheimer's Disease and Related Tauopathies

Kontaxi, C., Piccardo, P., & Gill, A. C. (2017) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2017.00056 · Cited by 138 · see citing works

<i>In Vivo</i> Imaging Reveals Dissociation between Caspase Activation and Acute Neuronal Death in Tangle-Bearing Neurons

Spires-Jones, T. L., de Calignon, A., Matsui, T., Zehr, C., Pitstick, R., Wu, H.-Y., Osetek, J. D., Jones, P. B., Bacskai, B. J., Feany, M. B., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3072-08.2008 · Cited by 137 · see citing works

Proteolytic processing of tau

Wang, Y., Garg, S., Mandelkow, E., & Mandelkow�, E. (2010) · Biochemical Society Transactions · doi:10.1042/bst0380955 · Cited by 140 · see citing works

Intracellular Calcium Dysregulation: Implications for Alzheimer’s Disease

Magi, S., Castaldo, P., Macrì, M. L., Maiolino, M., Matteucci, A., Bastioli, G., Gratteri, S., Amoroso, S., & Lariccia, V. (2016) · BioMed Research International · doi:10.1155/2016/6701324 · Cited by 137 · see citing works

Truncated tau and Aβ cooperatively impair mitochondria in primary neurons

Quintanilla, R. A., Dolan, P. J., Jin, Y. N., & Johnson, G. V. W. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.02.007 · Cited by 136 · see citing works

Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer’s disease

Roberts, M., Sevastou, I., Imaizumi, Y., Mistry, K., Talma, S., Dey, M., Gartlon, J., Ochiai, H., Zhou, Z., Akasofu, S., et al. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-0884-2 · Cited by 135 · see citing works

Contribution of the Nrf2 Pathway on Oxidative Damage and Mitochondrial Failure in Parkinson and Alzheimer’s Disease

Villavicencio-Tejo, F., & Quintanilla, R. A. (2021) · Antioxidants · doi:10.3390/antiox10071069 · Cited by 135 · see citing works

Pre‐synaptic C‐terminal truncated tau is released from cortical synapses in Alzheimer's disease

Sokolow, S., Henkins, K. M., Bilousova, T., Gonzalez, B., Vinters, H. V., Miller, C. A., Cornwell, L., Poon, W. W., & Gylys, K. H. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.12991 · Cited by 133 · see citing works

Role of the Tau N-terminal region in microtubule stabilization revealed by newendogenous truncated forms

Derisbourg, M. J., Leghay, C., Chiappetta, G., Fernández-Gómez, F.-J., Laurent, C., Demeyer, D., Carrier, S., Buée‐Scherrer, V., Blum, D. L., Vinh, J., et al. (2015) · Scientific Reports · doi:10.1038/srep09659 · Cited by 133 · see citing works

Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease

Salminen, A., Ojala, J. O., Kaarniranta, K., Hiltunen, M., & Soininen, H. S. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.10.006 · Cited by 129 · see citing works

Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease

Noble, W., Garwood, C., Stephenson, J., Kinsey, A. M., Hanger, D., & Anderton, B. (2009) · The FASEB Journal · doi:10.1096/fj.08-113795 · Cited by 123 · see citing works

The Role of Neuronal NLRP1 Inflammasome in Alzheimer’s Disease: Bringing Neurons into the Neuroinflammation Game

Yap, J. K. Y., Pickard, B. S., Chan, E. W. L., & Gan, S. Y. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1638-7 · Cited by 127 · see citing works

NO synthase 2 ( <i>NOS2</i> ) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease

Colton, C. A., Vitek, M. P., Wink, D. A., Xu, Q., Cantillana, V., Previti, M. L., Van Nostrand, W. E., Weinberg, J. B., & Dawson, H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601075103 · Cited by 128 · see citing works

Caspase-6 and neurodegeneration

Graham, R. K., Ehrnhoefer, D. E., & Hayden, M. R. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.09.001 · Cited by 127 · see citing works

Nucleation-dependent Tau Filament Formation

Congdon, E. E., Kim, S., Bonchak, J., Songrug, T., Anastasios Matzavinos, A., & Kuret, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800247200 · Cited by 126 · see citing works

The Role of Caspase Cleavage of Tau in Alzheimer Disease Neuropathology

Cotman, C. W., Poon, W. W., Rissman, R. A., & Blurton-Jones, M. (2005) · Journal of Neuropathology &amp; Experimental Neurology · doi:10.1093/jnen/64.2.104 · Cited by 199 · see citing works

Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease

Gamblin, T. C., Chen, F., Zambrano, A., Abraha, A., Lagalwar, S., Guillozet, A. L., Lu, M., Fu, Y., Garcia-Sierra, F., LaPointe, N., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1630428100 · Cited by 831 · see citing works

Early N-Terminal Changes and Caspase-6 Cleavage of Tau in Alzheimer's Disease

Horowitz, P. M., Patterson, K. R., Guillozet-Bongaarts, A. L., Reynolds, M. R., Carroll, C. A., Weintraub, S. T., Bennett, D. A., Cryns, V. L., Berry, R. W., & Binder, L. I. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1988-04.2004 · Cited by 215 · see citing works

Halting of Caspase Activity Protects Tau from MC1-Conformational Change and Aggregation

Mead, E., Kestoras, D., Gibson, Y., Hamilton, L., Goodson, R. J., Jones, S., Eversden, S., Davies, P., O’Neill, M. J., Hutton, M. L., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150960 · Cited by 26 · see citing works

Investigating Tau Mediated Toxicity in Alzheimer's Disease and the Protein Complex Responsible for Tau Cleavage

Opland, C. K. (2026) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/gzzy-1234