Blundell, Tom L.

Comparative Protein Modelling by Satisfaction of Spatial Restraints

Šali, A., & Blundell, T. L. (1993) · Journal of Molecular Biology

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 12,977

mCSM: Predicting the effects of mutations in proteins using graph-based signatures

Pires, D. E. V., Ascher, D. B., & Blundell, T. L. (2014) · Bioinformatics

Protein Structure and DynamicsGenomics and Rare Diseases

Cited by 1,066

DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach

Pires, D. E. V., Ascher, D. B., & Blundell, T. L. (2014) · Nucleic Acids Research

Protein Structure and DynamicsGenomics and Rare Diseases

Cited by 932

Insights into DNA recombination from the structure of a RAD51–BRCA2 complex

Pellegrini, L., Yu, D. S., Lo, T., Anand, S., Lee, M., Blundell, T. L., & Venkitaraman, A. R. (2002) · Nature

DNA Repair MechanismsBRCA gene mutations in cancer

Cited by 704

Structure of Rhombohedral 2 Zinc Insulin Crystals

ADAMS, M. J., BLUNDELL, T. L., DODSON, E. J., DODSON, G. G., VIJAYAN, M., BAKER, E. N., HARDING, M. M., HODGKIN, D. C., RIMMER, B., & SHEAT, S. (1969) · Nature

Enzyme Structure and FunctionCrystal structures of chemical compounds

Cited by 503

Utilizing graph machine learning within drug discovery and development

Gaudelet, T., Day, B., Jamasb, A. R., Soman, J., Regep, C., Liu, G., Hayter, J. B. R., Vickers, R., Roberts, C., Tang, J., et al. (2021) · Briefings in Bioinformatics

Computational Drug Discovery MethodsBioinformatics and Genomic Networks

Cited by 313

Structural Biology and Drug Discovery of Difficult Targets: The Limits of Ligandability

Surade, S., & Blundell, T. L. (2012) · Chemistry & Biology

Computational Drug Discovery MethodsEnzyme Structure and Function

Cited by 230

Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d

Brotherton, D. H., Dhanaraj, V., Wick, S., Brizuela, L., Domaille, P. J., Volyanik, E., Xu, X., Parisini, E., Smith, B. O., Archer, S. J., et al. (1998) · Nature

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 210

Structure of porphobilinogen deaminase reveals a flexible multidomain polymerase with a single catalytic site

Louie, G. V., Brownlie, P. D., Lambert, R., Cooper, J. B., Blundell, T. L., Wood, S. P., Warren, M. J., Woodcock, S. C., & Jordan, P. M. (1992) · Nature

Porphyrin Metabolism and DisordersPorphyrin and Phthalocyanine Chemistry

Cited by 199

mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance

Pires, D. E. V., Blundell, T. L., & Ascher, D. B. (2016) · Scientific Reports

Computational Drug Discovery MethodsProtein Structure and Dynamics

Cited by 143

An evaluation of the performance of an automated procedure for comparative modelling of protein tertiary structure

Srinivasan, N., & Blundell, T. L. (1993) · "Protein Engineering, Design and Selection"

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 119

Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer

Nookala, R. K., Langemeyer, L., Pacitto, A., Ochoa-Montaño, B., Donaldson, J. C., Blaszczyk, B. K., Chirgadze, D. Y., Barr, F. A., Bazan, J. F., & Blundell, T. L. (2012) · Open Biology

Renal cell carcinoma treatmentPI3K/AKT/mTOR signaling in cancer

Cited by 106

In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity

Pires, D. E. V., Chen, J., Blundell, T. L., & Ascher, D. B. (2016) · Scientific Reports

Genomics and Rare DiseasesProtein Structure and Dynamics

Cited by 102

TIMBAL v2: update of a database holding small molecules modulating protein–protein interactions

Higueruelo, A. P., Jubb, H., & Blundell, T. L. (2013) · Database

Computational Drug Discovery MethodsBioinformatics and Genomic Networks

Cited by 93

Platinum: a database of experimentally measured effects of mutations on structurally defined protein-ligand complexes

Pires, D. E. V., Blundell, T. L., & Ascher, D. B. (2015) · Nucleic Acids Research

Computational Drug Discovery MethodsEnzyme Structure and Function

Cited by 91

PDBe-KB: collaboratively defining the biological context of structural data

PDBe-KB consortium, Varadi, M., Anyango, S., Armstrong, D., Berrisford, J., Choudhary, P., Deshpande, M., Nadzirin, N., Nair, S. S., Pravda, L., et al. (2022) · Nucleic Acids Research

Enzyme Structure and FunctionProtein Structure and Dynamics

Cited by 82

Decoding the similarities and differences among mycobacterial species

Malhotra, S., Vedithi, S. C., & Blundell, T. L. (2017) · PLOS Neglected Tropical Diseases

Mycobacterium research and diagnosisTuberculosis Research and Epidemiology

Cited by 63

Lst4, the yeast Fnip1/2 orthologue, is a DENN-family protein

Pacitto, A., Ascher, D. B., Wong, L. H., Blaszczyk, B. K., Nookala, R. K., Zhang, N., Dokudovskaya, S., Levine, T. P., & Blundell, T. L. (2015) · Open Biology

Cellular transport and secretionFungal and yeast genetics research

Cited by 28

Insights from aquaporin structures into drug-resistant sleeping sickness

Matusevicius, M., Corey, R. A., Gragera, M., Yamashita, K., Sprenger, T., Ungogo, M. A., Blaza, J. N., Castro-Hartmann, P., Chirgadze, D. Y., Chaitanya Vedithi, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory)

Trypanosoma species research and implicationsIon Transport and Channel Regulation

Cited by 1

Insights from aquaporin structures into drug-resistant sleeping sickness

Matusevicius, M., Corey, R. A., Gragera, M., Yamashita, K., Sprenger, T., Ungogo, M., Blaza, J. N., Castro-Hartmann, P., Chirgadze, D. Y., Chaitanya Vedithi, S., et al. (2026) · eLife

Trypanosoma species research and implicationsIon Transport and Channel Regulation

Cited by 1

Insights from aquaporin structures into drug-resistant sleeping sickness

Matusevicius, M., Corey, R. A., Gragera, M., Yamashita, K., Sprenger, T., Ungogo, M., Blaza, J. N., Castro-Hartmann, P., Chirgadze, D. Y., Chaitanya Vedithi, S., et al. (2026) · eLife

Trypanosoma species research and implicationsIon Transport and Channel Regulation

Cited by 1