Pluchino, Stefano

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

Kalra, H., Simpson, R. J., Ji, H., Aikawa, E., Altevogt, P., Askenase, P., Bond, V. C., Borràs, F. E., Breakefield, X., Budnik, V., et al. (2012) · PLoS Biology

Extracellular vesicles in diseaseCellular transport and secretion

Cited by 1,367

Microglia activated by IL-4 or IFN-γ differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells

Butovsky, O., Ziv, Y., Schwartz, A., Landa, G., Talpalar, A. E., Pluchino, S., Martino, G., & Schwartz, M. (2006) · Molecular and Cellular Neuroscience

Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 923

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

Shechter, R., London, A., Varol, C., Raposo, C., Cusimano, M., Yovel, G., Rolls, A., Mack, M., Pluchino, S., Martino, G., et al. (2009) · PLoS Medicine

Spinal Cord Injury ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 770

Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms

Bacigaluppi, M., Pluchino, S., Jametti, L. P., Kilic, E., Kilic, Ü., Salani, G., Brambilla, E., West, M. J., Comi, G., Martino, G., et al. (2009) · Brain

Neurogenesis and neuroplasticity mechanismsMesenchymal stem cell research

Cited by 350

Focus on Extracellular Vesicles: Physiological Role and Signalling Properties of Extracellular Membrane Vesicles

Iraci, N., Leonardi, T., Gessler, F., Vega, B., & Pluchino, S. (2016) · International Journal of Molecular Sciences

Extracellular vesicles in diseaseCellular transport and secretion

Cited by 301

Synergy between immune cells and adult neural stem/progenitor cells promotes functional recovery from spinal cord injury

Ziv, Y., Avidan, H., Pluchino, S., Martino, G., & Schwartz, M. (2006) · Proceedings of the National Academy of Sciences

Spinal Cord Injury ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 285

Macrophage-derived extracellular succinate licenses neural stem cells to suppress chronic neuroinflammation

Peruzzotti-Jametti, L., Bernstock, J. D., Vicario, N., Costa, A. S. H., Kwok, C. K., Leonardi, T., Booty, L. M., Bicci, I., Balzarotti, B., Volpe, G., et al. (2018) · Cell Stem Cell

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 285

Neural stem cells traffic functional mitochondria via extracellular vesicles

Peruzzotti-Jametti, L., Bernstock, J. D., Willis, C. M., Manferrari, G., Rogall, R., Fernandez-Vizarra, E., Williamson, J. C., Braga, A., van den Bosch, A., Leonardi, T., et al. (2021) · PLOS Biology

Extracellular vesicles in diseaseMesenchymal stem cell research

Cited by 263

Mitochondrial complex I activity in microglia sustains neuroinflammation

Peruzzotti-Jametti, L., Willis, C. M., Krzak, G., Hamel, R., Pirvan, L., Ionescu, R.-B., Reisz, J. A., Prag, H. A., Garcia-Segura, M. E., Wu, V., et al. (2024) · Nature

Neuroinflammation and Neurodegeneration MechanismsMitochondrial Function and Pathology

Cited by 239

Human neural stem cells ameliorate autoimmune encephalomyelitis in non‐human primates

Pluchino, S., Gritti, A., Blezer, E., Amadio, S., Brambilla, E., Borsellino, G., Cossetti, C., Del Carro, U., Comi, G., 't Hart, B., et al. (2009) · Annals of Neurology

Multiple Sclerosis Research StudiesMesenchymal stem cell research

Cited by 208

Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity

Reitmeir, R., Kilic, E., Kilic, Ü., Bacigaluppi, M., ElAli, A., Salani, G., Pluchino, S., Gassmann, M., & Hermann, D. M. (2011) · Brain

Stroke Rehabilitation and RecoveryErythropoietin and Anemia Treatment

Cited by 156

Extracellular vesicles are independent metabolic units with asparaginase activity

Iraci, N., Gaude, E., Leonardi, T., Costa, A. S. H., Cossetti, C., Peruzzotti-Jametti, L., Bernstock, J. D., Saini, H. K., Gelati, M., Vescovi, A. L., et al. (2017) · Nature Chemical Biology

Extracellular vesicles in diseaseAmino Acid Enzymes and Metabolism

Cited by 134

Neural stem/precursor cells for the treatment of ischemic stroke

Bacigaluppi, M., Pluchino, S., Martino, G., Kilic, E., & Hermann, D. M. (2008) · Journal of the Neurological Sciences

Neurogenesis and neuroplasticity mechanismsMesenchymal stem cell research

Cited by 111

The role of neural stem cells in regulating glial scar formation and repair

Nicaise, A. M., D’Angelo, A., Ionescu, R.-B., Krzak, G., Willis, C. M., & Pluchino, S. (2022) · Cell and Tissue Research

Neurogenesis and neuroplasticity mechanismsSpinal Cord Injury Research

Cited by 65

Intracerebroventricularly delivered VEGF promotes contralesional corticorubral plasticity after focal cerebral ischemia via mechanisms involving anti-inflammatory actions

Herz, J., Reitmeir, R., Hagen, S. I., Reinboth, B. S., Guo, Z., Zechariah, A., ElAli, A., Doeppner, T. R., Bacigaluppi, M., Pluchino, S., et al. (2012) · Neurobiology of Disease

Neuroinflammation and Neurodegeneration MechanismsStroke Rehabilitation and Recovery

Cited by 62

Small Extracellular Vesicles Secreted by Nigrostriatal Astrocytes Rescue Cell Death and Preserve Mitochondrial Function in Parkinson's Disease

Leggio, L., L'Episcopo, F., Magrì, A., Ulloa‐Navas, M. J., Paternò, G., Vivarelli, S., Bastos, C. A. P., Tirolo, C., Testa, N., Caniglia, S., et al. (2022) · Advanced Healthcare Materials

Extracellular vesicles in diseaseParkinson's Disease Mechanisms and Treatments

Cited by 54

Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming

Bernstock, J. D., Ye, D., Gessler, F. A., Lee, Y.-J., Peruzzotti-Jametti, L., Baumgarten, P., Johnson, K. R., Maric, D., Yang, W., Kögel, D., et al. (2017) · Scientific Reports

Ubiquitin and proteasome pathwaysGlioma Diagnosis and Treatment

Cited by 46

Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis

Ionescu, R.-B., Nicaise, A. M., Reisz, J. A., Williams, E. C., Prasad, P., Willis, C. M., Simões-Abade, M. B. C., Sbarro, L., Dzieciatkowska, M., Stephenson, D., et al. (2024) · Cell Stem Cell

Multiple Sclerosis Research StudiesTelomeres, Telomerase, and Senescence

Cited by 34

Neural Stem Cell‐Derived Extracellular Vesicles for Advanced Neural Repair

Moretti, E. H., Lin, A. L. Y., Peruzzotti‐Jametti, L., Pluchino, S., & Mozafari, S. (2025) · Journal of Neurochemistry

Extracellular vesicles in diseaseMesenchymal stem cell research

Cited by 16

Brain organoid methodologies to explore mechanisms of disease in progressive multiple sclerosis

Simões-Abade, M. B. C., Patterer, M., Nicaise, A. M., & Pluchino, S. (2024) · Frontiers in Cellular Neuroscience

Multiple Sclerosis Research StudiesPluripotent Stem Cells Research

Cited by 14

Most prominent challenges in translational neuroscience and strategic solutions to bridge the gaps: Perspectives from an editorial board interrogation

Hermann, D. M., Bacigaluppi, M., Bassetti, C. L., Bassotti, G., Boltze, J., Chan, A., Dalkara, T., Denes, A., Diez-Tejedor, E., Dodel, R., et al. (2025) · Exploration of Neuroscience

Health and Medical Research ImpactsAnimal testing and alternatives

Cited by 13

Mitochondria transfer for myelin repair

Mozafari, S., Peruzzotti-Jametti, L., & Pluchino, S. (2026) · Journal of Cerebral Blood Flow & Metabolism

Multiple Sclerosis Research StudiesMitochondrial Function and Pathology

Cited by 10

Remyelination of chronic demyelinated lesions with directly induced neural stem cells

Peruzzotti-Jametti, L., Vicario, N., Volpe, G., Rizzi, S., Kwok, C., Lombardi, I., Bergholt, M. S., Barea-Moya, L., D’Angelo, A., Nicaise, A. M., et al. (2025) · Brain

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 8

Metabolic control of microglia

Garcia-Segura, M. E., Pluchino, S., & Peruzzotti-Jametti, L. (2024) · Advances in Neurobiology

Neuroinflammation and Neurodegeneration MechanismsImmune cells in cancer

Cited by 4