Hruban, Ralph H.

A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer

Mello, S. S., Valente, L. J., Raj, N., Seoane, J. A., Flowers, B. M., McClendon, J., Bieging-Rolett, K. T., Lee, J., Ivanochko, D., Kozak, M. M., et al. (2017) · Cancer Cell

Cancer-related Molecular PathwaysHippo pathway signaling and YAP/TAZ

Cited by 179

Cardiomyopathy of obesity: A clinicopathologic evaluation of 43 obese patients with heart failure

Kasper, E. K., Hruban, R. H., & Baughman, K. L. (1992) · The American Journal of Cardiology

Cardiovascular Function and Risk FactorsHeart Failure Treatment and Management

Cited by 175

Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia

Shi, G., Zhu, L., Sun, Y., Bettencourt, R., Damsz, B., Hruban, R. H., & Konieczny, S. F. (2009) · Gastroenterology

Pancreatic and Hepatic Oncology ResearchPancreatic function and diabetes

Cited by 168

Digital next-generation sequencing identifies low-abundance mutations in pancreatic juice samples collected from the duodenum of patients with pancreatic cancer and intraductal papillary mucinous neoplasms

Yu, J., Sadakari, Y., Shindo, K., Suenaga, M., Brant, A., Almario, J. A. N., Borges, M., Barkley, T., Fesharakizadeh, S., Ford, M., et al. (2017) · Gut

Pancreatic and Hepatic Oncology ResearchCancer Genomics and Diagnostics

Cited by 164

Molecular pathogenesis of pancreatic cancer

Hansel, D. E., Kern, S. E., & Hruban, R. H. (2003) · Annual Review of Genomics and Human Genetics

Pancreatic and Hepatic Oncology ResearchCancer Genomics and Diagnostics

Cited by 159

Periampullary and Pancreatic Incidentaloma: A Single Institution??s Experience With an Increasingly Common Diagnosis

Winter, J. M., Cameron, J. L., Lillemoe, K. D., Campbell, K. A., Chang, D., Riall, T. S., Coleman, J., Sauter, P. K., Canto, M., Hruban, R. H., et al. (2006) · Annals of Surgery

Pancreatic and Hepatic Oncology ResearchNeuroendocrine Tumor Research Advances

Cited by 156

Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas: A Report from The Pancreatic Surgery Consortium

Attiyeh, M. A., Fernández-del Castillo, C., Al Efishat, M., Eaton, A. A., Gönen, M., Batts, R., Pergolini, I., Rezaee, N., Lillemoe, K. D., Ferrone, C. R., et al. (2018) · Annals of Surgery

Pancreatic and Hepatic Oncology ResearchNeuroendocrine Tumor Research Advances

Cited by 146

Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication

Ardeljan, D., Steranka, J. P., Liu, C., Li, Z., Taylor, M. S., Payer, L. M., Gorbounov, M., Sarnecki, J. S., Deshpande, V., Hruban, R. H., et al. (2020) · Nature Structural & Molecular Biology

Chromosomal and Genetic VariationsDNA Repair Mechanisms

Cited by 135

Familial pancreatic cancer

Hruban, R. H., Petersen, G. M., Goggins, M., Tersmette, A. C., Offerhaus, G. J. A., Falatko, F., Yeo, C. J., & Kern, S. E. (1999) · Annals of Oncology

Pancreatic and Hepatic Oncology ResearchGenetic factors in colorectal cancer

Cited by 134

Intraductal papillary mucinous neoplasms arise from multiple independent clones, each with distinct mutations

Fischer, C. G., Beleva Guthrie, V., Braxton, A. M., Zheng, L., Wang, P., Song, Q., Griffin, J. F., Chianchiano, P. E., Hosoda, W., Niknafs, N., et al. (2019) · Gastroenterology

Pancreatic and Hepatic Oncology ResearchCancer Genomics and Diagnostics

Cited by 129

Neutrophil-to-lymphocyte ratio is a predictive marker for invasive malignancy in intraductal papillary mucinous neoplasms of the pancreas

Gemenetzis, G., Bagante, F., Griffin, J. F., Rezaee, N., Javed, A. A., Manos, L. L., Lennon, A. M., Wood, L. D., Hruban, R. H., Zheng, L., et al. (2017) · Annals of Surgery

Inflammatory Biomarkers in Disease PrognosisPancreatic and Hepatic Oncology Research

Cited by 127

Concordant loss of MTAP and p16/CDKN2A expression in pancreatic intraepithelial neoplasia: evidence of homozygous deletion in a noninvasive precursor lesion

Hustinx, S. R., Leoni, L. M., Yeo, C. J., Brown, P. N., Goggins, M., Kern, S. E., Hruban, R. H., & Maitra, A. (2005) · Modern Pathology

Pancreatic and Hepatic Oncology ResearchGenetic factors in colorectal cancer

Cited by 125

Well-differentiated pancreatic neuroendocrine tumors: from genetics to therapy

de Wilde, R. F., Edil, B. H., Hruban, R. H., & Maitra, A. (2012) · Nature Reviews Gastroenterology & Hepatology

Neuroendocrine Tumor Research AdvancesPancreatic and Hepatic Oncology Research

Cited by 122

Precancerous neoplastic cells can move through the pancreatic ductal system

Makohon-Moore, A. P., Matsukuma, K., Zhang, M., Reiter, J. G., Gerold, J. M., Jiao, Y., Sikkema, L., Attiyeh, M. A., Yachida, S., Sandone, C., et al. (2018) · Nature

Cancer Genomics and DiagnosticsPancreatic and Hepatic Oncology Research

Cited by 120

Why is pancreatic cancer so deadly? The pathologist's view

Hruban, R. H., Gaida, M. M., Thompson, E., Hong, S., Noë, M., Brosens, L. A., Jongepier, M., Offerhaus, G. J. A., & Wood, L. D. (2019) · The Journal of Pathology

Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and Treatment

Cited by 115

Deleterious Germline Mutations Are a Risk Factor for Neoplastic Progression Among High-Risk Individuals Undergoing Pancreatic Surveillance

Abe, T., Blackford, A. L., Tamura, K., Ford, M., McCormick, P., Chuidian, M., Almario, J. A., Borges, M., Lennon, A. M., Shin, E. J., et al. (2019) · Journal of Clinical Oncology

Pancreatic and Hepatic Oncology ResearchBRCA gene mutations in cancer

Cited by 102

Very Long-term Survival Following Resection for Pancreatic Cancer Is Not Explained by Commonly Mutated Genes: Results of Whole-Exome Sequencing Analysis

Dal Molin, M., Zhang, M., de Wilde, R. F., Ottenhof, N. A., Rezaee, N., Wolfgang, C. L., Blackford, A., Vogelstein, B., Kinzler, K. W., Papadopoulos, N., et al. (2015) · Clinical Cancer Research

Pancreatic and Hepatic Oncology ResearchCancer Genomics and Diagnostics

Cited by 101

Disruption of p16 and Activation of Kras in Pancreas Increase Ductal Adenocarcinoma Formation and Metastasis in vivo

Qiu, W., Sahin, F., Iacobuzio-Donahue, C. A., Garcia-Carracedo, D., Wang, W. M., Kuo, C.-Y., Chen, D., Arking, D. E., Lowy, A. M., Hruban, R. H., et al. (2011) · Oncotarget

Pancreatic and Hepatic Oncology ResearchCancer Genomics and Diagnostics

Cited by 99

Transcriptomic Biomarkers for the Accurate Diagnosis of Myocarditis

Heidecker, B., Kittleson, M. M., Kasper, E. K., Wittstein, I. S., Champion, H. C., Russell, S. D., Hruban, R. H., Rodriguez, E. R., Baughman, K. L., & Hare, J. M. (2011) · Circulation

Viral Infections and Immunology ResearchCardiac Fibrosis and Remodeling

Cited by 97

Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer

Tamura, K., Yu, J., Hata, T., Suenaga, M., Shindo, K., Abe, T., MacGregor-Das, A., Borges, M., Wolfgang, C. L., Weiss, M. J., et al. (2018) · Proceedings of the National Academy of Sciences

Pancreatic and Hepatic Oncology ResearchEndoplasmic Reticulum Stress and Disease

Cited by 95

PAM4-Reactive MUC1 Is a Biomarker for Early Pancreatic Adenocarcinoma

Gold, D. V., Karanjawala, Z., Modrak, D. E., Goldenberg, D. M., & Hruban, R. H. (2007) · Clinical Cancer Research

Pancreatic and Hepatic Oncology ResearchGlycosylation and Glycoproteins Research

Cited by 93

Risk of Pancreatic Cancer Among Individuals With Pathogenic Variants in the ATM Gene

Hsu, F.-C., Roberts, N. J., Childs, E., Porter, N., Rabe, K. G., Borgida, A., Ukaegbu, C., Goggins, M. G., Hruban, R. H., Zogopoulos, G., et al. (2021) · JAMA Oncology

Pancreatic and Hepatic Oncology ResearchBRCA gene mutations in cancer

Cited by 91

Homozygous deletion of the MTAP gene in invasive adenocarcinoma of the pancreas and in periampullary cancer: A potential new target for therapy

Hustinx, S. R., Hruban, R. H., Leoni, L. M., Iacobuzio-Donahue, C., Cameron, J. L., Yeo, C. J., Brown, P. N., Argani, P., Ashfaq, R., Fukushima, N., et al. (2005) · Cancer Biology & Therapy

Pancreatic and Hepatic Oncology ResearchBiochemical and Molecular Research

Cited by 90

The Role of Inherited Pathogenic CDKN2A Variants in Susceptibility to Pancreatic Cancer

Kimura, H., Klein, A. P., Hruban, R. H., & Roberts, N. J. (2021) · Pancreas

Pancreatic and Hepatic Oncology ResearchBRCA gene mutations in cancer

Cited by 65