Lovestone, Simon

GSK-3β inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila

Mudher, A., Shepherd, D., Newman, T. A., Mildren, P., Jukes, J. P., Squire, A., Mears, A., Berg, S., MacKay, D., Asuni, A. A., et al. (2004) · Molecular Psychiatry

Alzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

Cited by 265

Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease

Kehoe, P. G., Russ, C., McIlroy, S., Williams, H., Holmans, P., Holmes, C., Liolitsa, D., Vahidassr, D., Powell, J., McGleenon, B., et al. (1999) · Nature Genetics

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 260

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

Coppola, G., Chinnathambi, S., Lee, J. J., Dombroski, B. A., Baker, M. C., Soto-Ortolaza, A. I., Lee, S. E., Klein, E., Huang, A. Y., Sears, R., et al. (2012) · Human Molecular Genetics

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 240

Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology

Sattlecker, M., Kiddle, S. J., Newhouse, S., Proitsi, P., Nelson, S., Williams, S., Johnston, C., Killick, R., Simmons, A., Westman, E., et al. (2014) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 223

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway

Killick, R., Ribe, E. M., Al-Shawi, R., Malik, B., Hooper, C., Fernandes, C., Dobson, R., Nolan, P. M., Lourdusamy, A., Furney, S., et al. (2014) · Molecular Psychiatry

Alzheimer's disease research and treatmentsClusterin in disease pathology

Cited by 222

Phosphorylation of tau by glycogen synthase kinase-3β in intact mammalian cells: The effects on the organization and stability of microtubules

Lovestone, S., Hartley, C. L., Pearce, J., & Anderton, B. H. (1996) · Neuroscience

Alzheimer's disease research and treatmentsMicrotubule and mitosis dynamics

Cited by 201

Convergent genetic and expression data implicate immunity in Alzheimer's disease

International Genomics of Alzheimer's Disease Consortium (IGAP), Jones, L., Lambert, J., Wang, L., Choi, S., Harold, D., Vedernikov, A., Escott‐Price, V., Stone, T., Richards, A., et al. (2015) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 199

Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease: A Randomized Clinical Trial

Howard, R., Zubko, O., Bradley, R., Harper, E., Pank, L., O’Brien, J., Fox, C., Tabet, N., Livingston, G., Bentham, P., et al. (2020) · JAMA Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 194

Do antidepressants regulate how cortisol affects the brain?

Pariante, C. M., Thomas, S. A., Lovestone, S., Makoff, A., & Kerwin, R. W. (2004) · Psychoneuroendocrinology

Stress Responses and CortisolTreatment of Major Depression

Cited by 194

Mitochondrial genes are altered in blood early in Alzheimer's disease

Lunnon, K., Keohane, A., Pidsley, R., Newhouse, S., Riddoch-Contreras, J., Thubron, E. B., Devall, M., Soininen, H., Kłoszewska, I., Mecocci, P., et al. (2017) · Neurobiology of Aging

Mitochondrial Function and PathologyAlzheimer's disease research and treatments

Cited by 190

Elevated DNA methylation across a 48‐kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology

Smith, R. G., Hannon, E., De Jager, P. L., Chibnik, L., Lott, S. J., Condliffe, D., Smith, A. R., Haroutunian, V., Troakes, C., Al‐Sarraj, S., et al. (2018) · Alzheimer's & Dementia

Epigenetics and DNA MethylationDementia and Cognitive Impairment Research

Cited by 184

Blood-Based Biomarkers of Alzheimer's Disease: Challenging but Feasible

Thambisetty, M., & Lovestone, S. (2010) · Biomarkers in Medicine

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 182

Developing novel blood‐based biomarkers for Alzheimer's disease

Snyder, H. M., Carrillo, M. C., Grodstein, F., Henriksen, K., Jeromin, A., Lovestone, S., Mielke, M. M., O'Bryant, S., Sarasa, M., Sj⊘gren, M., et al. (2014) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 177

The reliability of a deep learning model in clinical out-of-distribution MRI data: A multicohort study

Mårtensson, G., Ferreira, D., Granberg, T., Cavallin, L., Oppedal, K., Padovani, A., Rektorova, I., Bonanni, L., Pardini, M., Kramberger, M. G., et al. (2020) · Medical Image Analysis

Dementia and Cognitive Impairment ResearchDomain Adaptation and Few-Shot Learning

Cited by 176

Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease

Sofola, O., Kerr, F., Rogers, I., Killick, R., Augustin, H., Gandy, C., Allen, M. J., Hardy, J., Lovestone, S., & Partridge, L. (2010) · PLoS Genetics

Alzheimer's disease research and treatmentsNeurobiology and Insect Physiology Research

Cited by 174

Increased plasma neurofilament light chain concentration correlates with severity of post-mortem neurofibrillary tangle pathology and neurodegeneration

Ashton, N. J., Leuzy, A., Lim, Y. M., Troakes, C., Hortobágyi, T., Höglund, K., Aarsland, D., Lovestone, S., Schöll, M., Blennow, K., et al. (2019) · Acta Neuropathologica Communications

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 172

p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells

Hooper, C., Meimaridou, E., Tavassoli, M., Melino, G., Lovestone, S., & Killick, R. (2007) · Neuroscience Letters

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 165

Inflammatory Proteins in Plasma Are Associated with Severity of Alzheimer’s Disease

Leung, R., Proitsi, P., Simmons, A., Lunnon, K., Güntert, A., Kronenberg, D., Pritchard, M., Tsolaki, M., Mecocci, P., Kloszewska, I., et al. (2013) · PLoS ONE

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 160

Antidepressants enhance glucocorticoid receptor function in vitro by modulating the membrane steroid transporters

Pariante, C. M., Makoff, A., Lovestone, S., Feroli, S., Heyden, A., Miller, A. H., & Kerwin, R. W. (2001) · British Journal of Pharmacology

Estrogen and related hormone effectsStress Responses and Cortisol

Cited by 159

Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer’s disease

Furney, S. J., Simmons, A., Breen, G., Pedroso, I., Lunnon, K., Proitsi, P., Hodges, A., Powell, J., Wahlund, L.-O., Kloszewska, I., et al. (2011) · Molecular Psychiatry

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 157

Postnatal Psychiatric Illness: the Impact on Partners

Lovestone, S., & Kumar, R. (1993) · British Journal of Psychiatry

Maternal Mental Health During Pregnancy and PostpartumFamily Caregiving in Mental Illness

Cited by 151

Circulating Proteomic Signatures of Chronological Age

Menni, C., Kiddle, S. J., Mangino, M., Viñuela, A., Psatha, M., Steves, C., Sattlecker, M., Buil, A., Newhouse, S., Nelson, S., et al. (2015) · The Journals of Gerontology: Series A

Genetics, Aging, and Longevity in Model OrganismsAging and Gerontology Research

Cited by 144

Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain

Condliffe, D., Wong, A., Troakes, C., Proitsi, P., Patel, Y., Chouliaras, L., Fernandes, C., Cooper, J., Lovestone, S., Schalkwyk, L., et al. (2014) · Neurobiology of Aging

Epigenetics and DNA MethylationAlzheimer's disease research and treatments

Cited by 131

SNPs Associated with Cerebrospinal Fluid Phospho-Tau Levels Influence Rate of Decline in Alzheimer's Disease

Cruchaga, C., Kauwe, J. S. K., Mayo, K., Spiegel, N., Bertelsen, S., Nowotny, P., Shah, A. R., Abraham, R., Hollingworth, P., Harold, D., et al. (2010) · PLoS Genetics

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 128