Blood-Based Biomarkers of Alzheimer's Disease: Challenging but Feasible
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Blood-based biomarkers present a considerable challenge: technically, as blood is a complex tissue and conceptually, as blood lacks direct contact with brain. Nonetheless, increasing evidence suggests that there is a blood protein signature, and possibly a transcript signature, that might act to increase confidence in diagnosis, be used to predict progression in either disease or prodromal states, and that may also be used to monitor disease progression. Evidence for this optimism comes partly from candidate protein studies, including those suggesting that amyloid-beta measures might have value in prediction and those studies of inflammatory markers that consistently show change in Alzheimer's disease, and partly from true proteomics studies that are beginning to identify markers in blood that replicate across studies and populations.
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Blood is an interesting potential source of biomarkers because it allows repeated measurements, is easily obtained, and is highly suitable for high-throughput measurements.
“Blood is an interesting potential source of biomarkers because it allows repeated measurements, is easily obtained, and is highly suitable for high-throughput measurements [29].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [29]
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- Authors
- Thambisetty, M., & Lovestone, S.
- Affiliations
- National Institutes of Health (US)
- King's College London (GB)
- Corresponding author
- Lovestone, Simon
- Venue
- Biomarkers in Medicine
- Publisher
- Informa UK Limited
- Published
- 2010-02
- Volume
- 4
- Issue
- 1
- Pages
- 65-79
- ISSN
- 1752-0363 (ISSN-L)
- 1752-0371
- PMC
- PMC2863057
- OpenAlex
- W2058838468
- Cited by
- 182
- References
- 108
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 12 · 2023: 5 · 2022: 12 · 2021: 17 · 2020: 13 · 2019: 11 · 2018: 14 · 2017: 11 · 2016: 11 · 2015: 12 · 2014: 16 · 2013: 16 · 2012: 14
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biomarkers in Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- NIHR
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Keywords
- Alzheimer's disease, blood-based biomarkers, amyloid-beta, inflammatory markers, disease progression prediction, prodromal Alzheimer's disease, disease surveillance, proteomics
- MeSH terms
- Alzheimer Disease, Apolipoproteins E, C-Reactive Protein, Genetic Markers, Homocysteine, Humans, Longitudinal Studies, RNA, Biomarkers, Amyloid beta-Peptides, Proteomics
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